Results 61 to 70 of about 12,305 (210)

Changes in activin and activin receptor subunit expression in rat liver during the development of CCl4-induced cirrhosis

, 2003
Amounts of betaA-activin, betaC-activin, activin receptor subunits ActRIIA and ActRIIB mRNA, and betaA- and betaC-activin subunit protein immunoreactivity were investigated in male Lewis rats, either untreated or after 5 or 10 weeks of CCl(4) treatment ...
Gold, J., Wheatley, M., Groome, P., Fleming, S., Francis, J., Mellor, L., Cranfield, Mark, Risbridger, P., Zimmermann, Arthur   +8 more
core   +1 more source

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities

Disease Models & Mechanisms, 2021
Activin/myostatin signalling acts to induce skeletal muscle atrophy in adult mammals by inhibiting protein synthesis as well as promoting protein and organelle turnover.
Danielle Vaughan, Robert Mitchell, Oliver Kretz, David Chambers, Maciej Lalowski, Helge Amthor, Olli Ritvos, Arja Pasternack, Antonios Matsakas, Sakthivel Vaiyapuri, Tobias B. Huber, Bernd Denecke, Abir Mukherjee, Darius Widera, Ketan Patel   +14 more
doaj   +1 more source

One‐Step Induction of Oogonia‐Like and Pro‐Spermatogonia‐Like Cells From Porcine Pluripotent Stem Cells

Advanced Science, EarlyView.
This study established a one‐step method inducing pro‐spermatogonia‐like (activating SOX17) and oogonia‐like (activating SOX17/TFAP2C) cells from porcine pgEpiSCs with a NANOS3‐tdTomato reporter. EGF activates the core PGC program and supports survival; BMP4 further induces NANOS3 and DDX4 expression; IWR1 enhances PGCLC efficiency by suppressing ...
Pengcheng He, Liang Zhong, Tianzhi Chen, Yaxuan Yan, Xinze Chen, Runbo Li, Yingjie Wang, Yadi Teng, Minglei Zhi, Meng Wang, Jinying Zhang, Fan Zhao, Dengfeng Gao, Suying Cao, Jianyong Han   +14 more
wiley   +1 more source

Urinary Activin A is a novel biomarker reflecting renal inflammation and tubular damage in ANCA-associated vasculitis.

PLoS ONE, 2019
Activin A, a member of the transforming growth factor-beta superfamily, is a critical modulator of inflammation and plays a key role in controlling the cytokine cascade that drives the inflammatory response. However, the role of activin A in inflammatory
Yoshinori Takei, Shunsuke Takahashi, Masao Nakasatomi, Toru Sakairi, Hidekazu Ikeuchi, Yoriaki Kaneko, Keiju Hiromura, Yoshihisa Nojima, Akito Maeshima   +8 more
doaj   +1 more source

Variations in activin receptor, inhibin/activin subunit and follistatin mRNAs in human prostate tumour tissues.

, 2000
The possible role of activin in the regulation of malignant prostatic growth was studied using RNAase protection assays of activin receptors, inhibin/activin subunits and follistatin mRNAs in the human prostatic carcinoma cell lines LNCaP-FGC, -R and ...
Schaik, R.H.N. (Ron) van, F H de Jong, C D J Wierikx, Timmerman, MA (Marianna), Kwast, Theodorus, Steenbrugge, G.J. (Gert Jan) van, Wierikx, C.D., Oomen, Monique, Timmerman, M.A. (Marianna), Weerden, W.M. (Wytske) van, Wierikx, CDJ, G J van Steenbrugge, Jong, F.H. (Frank) de, Kwast, Th.H. (Theo) van der, M H Oomen, van Schaik, Ron, Steenbrugge, Gert jan, Jong, Frank, R H N van Schaik, W M van Weerden, van Weerden, Wytske; id_orcid, T H van der Kwast, Oomen, M.H.A. (Monique), M A Timmerman   +23 more
core   +1 more source

Working model on activin-inhibin-follistatin system in zebrafish ovary.

, 2022
(A) Intrafollicular distribution of the activin-inhibin-follistatin system. All activin/inhibin β subunits (inhbaa, inhbab and inhbb) are exclusively expressed in the somatic follicle cells together with inhibin α subunit (inha). In contrast, follistatin
Wei Ge (39218), Nana Ai (14216436), Weiyi Song (3441530), Cheng Zhao (2535307), Kun Wu (286745), Yue Zhai (3141960), Ruijing Geng (14216433)   +6 more
core   +1 more source

Follicle Stimulating Hormone in Cattle Breeding: Fundamentals, Innovations, and Scope

Animal Research and One Health, EarlyView.
FSH is crucial in cattle reproduction, with exogenous administration enhancing breeding and embryo production. Recombinant FSH offers advantages over pituitary‐extracted variants, including fewer injections, reduced stress, and safer production. These innovations improve breeding efficiency, optimize reproductive outcomes, and contribute to sustainable
Muhammad Shahzad, Hubdar Ali Kolachi, Jesse Oluwaseun Ayantoye, Xiaomeng Zhang, Muhammad Usman Mehmood, Rajilan Hilali Shanga, Pengcheng Wan, Xueming Zhao   +7 more
wiley   +1 more source

5-Deoxy-Δ 12,14 -Prostaglandin J 2 Down-Regulates Activin-Induced Activin Receptor, Smad, and Cytokines Expression via Suppression of NF-B and MAPK Signaling in HepG2 Cells [PDF]

, 2020
15-Deoxy-Δ 12,14 -prostaglandin J 2 (15d-PGJ 2 ) and activin are implicated in the control of apoptosis, cell proliferation, and inflammation in cells.
Chunghee Cho, Byung-Nam Cho, Young Il Kim, Youngchul Kim, Tae Won Goo, Seung-Won Park   +5 more
core  

Advanced In Vitro Platforms for Experimental Liver Research: From Organoids and Liver‐on‐Chip to Omics and Artificial Intelligence

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Hepatocytes perform essential physiological functions in the human body. Gaining more profound insight into the liver structure, diseases, and physiology by using in vitro models can help to propose more relevant clinical applications. Conventional in vitro liver models, such as two‐dimensional (2D) cell cultures, fail to adequately replicate ...
Seyedeh Kiana Teymorian, Pedram Asadi Sarabi, Abbas Piryaei, Massoud Vosough   +3 more
wiley   +1 more source