Results 61 to 70 of about 73,976 (284)

Human activin-A is expressed in the atherosclerotic lesion and promotes the contractile phenotype of smooth muscle cells [PDF]

, 1999
Activin is a member of the transforming growth factor-beta superfamily, and it modulates the proliferation and differentiation of various target cells. In this study, we investigated the role of activin in the initiation and progression
Achterberg, T.A.E. (Tanja) van, Aken, B.E. (Benien) van, Engelse, M.A. (Marten), Neele, J.M., Pannekoek, H. (Hans), Schaik, R.H.N. (Ron) van, Vries, C.J.M. (Carlie) de   +6 more
core   +3 more sources

Inhibition of Endothelial–Mesenchymal Transition Mediated by Activin Receptor Type IIA Attenuates Valvular Injury Induced by Group A Streptococcus in Lewis Rats

Frontiers in Bioscience-Landmark
Background: Rheumatic heart disease (RHD), which is caused mainly by Group A Streptococcus, leads to fibrotic damage to heart valves.
Zirong Lu, Yuan Li, Chuanghong Lu, Zhongyuan Meng, Ling Bai, Feng Huang, Zhiyu Zeng   +6 more
doaj   +1 more source

Activin B antagonizes RhoA signaling to stimulate mesenchymal morphology and invasiveness of clear cell renal cell carcinomas. [PDF]

PLoS ONE, 2014
Activin B belongs to the TGFβ family of growth factors and is upregulated in clear cell renal cell carcinoma cells by hypoxia inducible factors. Expression of Activin B is required for tumor growth in vivo and tumor cell invasion in vitro.
Ingrid Wacker, Jürgen Behrens
doaj   +1 more source

Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis [PDF]

, 2016
Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage.
Toofan, Parto, Wheadon, Helen
core   +1 more source

Activin A more prominently regulates muscle mass in primates than does GDF8

Nature Communications, 2017
Growth and differentiation factor 8 (GDF8) is a TGF-β superfamily member, and negative regulator of skeletal muscle mass. GDF8 inhibition results in prominent muscle growth in mice, but less impressive hypertrophy in primates, including man.
E. Latres, J. Mastaitis, Wen Fury, Lawrence Miloscio, Jesus Trejos, Jeffrey Pangilinan, H. Okamoto, Katie Cavino, Erqian Na, A. Papatheodorou, T. Willer, Yu Bai, Jee Hae Kim, A. Rafique, S. Jaspers, T. Stitt, A. Murphy, G. Yancopoulos, J. Gromada   +18 more
semanticscholar   +1 more source

Activin in the brain modulates anxiety-related behavior and adult neurogenesis. [PDF]

PLoS ONE, 2008
Activin, a member of the transforming growth factor-beta superfamily, is an endocrine hormone that regulates differentiation and proliferation of a wide variety of cells. In the brain, activin protects neurons from ischemic damage.
Hiroshi Ageta, Akiko Murayama, Rika Migishima, Satoshi Kida, Kunihiro Tsuchida, Minesuke Yokoyama, Kaoru Inokuchi   +6 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Activin-A up-regulates type I activin receptor mRNA levels in human immortalized extravillous trophoblast cells.

Reproductive Biology and Endocrinology, 2003
Activin is known to play an important regulatory role in reproduction, including pregnancy. To further examine the role and signaling mechanism of activin in regulating placental function, the steady-state level of activin type I receptor (ActRI) mRNA in
Leung Peter CK, Peng Chun, Chen Victor TS   +2 more
doaj   +1 more source

A Novel Signal Peptide Derived from Bacillus Licheniformis α-Amylase Efficiently Targets Recombinant Human Activin A to the Periplasm of Escherichia coli [PDF]

Journal of Cell and Molecular Research, 2018
Human activin A is a member of the transforming growth factor-β superfamily consists of two similar beta subunits. Activin A is expressed by different cells and displays numerous biological activities such as control of neuronal cell proliferation and ...
Zahra Hajihassan, Seyed kazem Hosseini, Alireza Zomorodipour   +2 more
doaj   +1 more source

Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance We recently reported that activin type II receptors (ActRIIs) blockade using bimagrumab could positively impact muscle wasting in mice and humans.
F. Morvan, J. Rondeau, C. Zou, G. Minetti, C. Scheufler, M. Scharenberg, C. Jacobi, Pascale Brebbia, Veronique Ritter, Gauthier Toussaint, Claudia Koelbing, X. Leber, Alain Schilb, Florian Witte, S. Lehmann, E. Koch, S. Geisse, D. Glass, E. Lach‐Trifilieff   +18 more
semanticscholar   +1 more source