Results 121 to 130 of about 21,210,719 (287)
Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B
Cell Communication and Signaling, 2015 BackgroundActivins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue.
O. E. Olsen +8 more
semanticscholar +1 more source
Inhibins, activins and follistatins: a review
Nigerian Postgraduate Medical Journal, 2008 The study of the regulation of the reproductive process has largely focused on the interplay between endocrine organs, gonads and the brain. The discovery of inhibins, activins and follistatins and elucidation of their actions has emphasised their role in human reproduction.
openaire +2 more sources
The Immunoregulatory and Hematopoietic Effects of Momelotinib in a Murine Bone Marrow Failure Model
Journal of Clinical Laboratory Analysis, EarlyView.Momelotinib, a selective small‐molecule inhibitor of JAK1/2 and the bone morphogenic protein receptor kinase activin A receptor type I (ACVR1), exerts its effects by inhibiting the overactivation of the BMP/ACVR1/SMAD signaling pathway. This inhibition reduces hepcidin production in hepatocytes, and reduces inflammation, aberrant cytokine signaling ...
Yue Zhang +7 more
wiley +1 more source
PLoS ONE, 2019 Activin A, a member of the transforming growth factor-beta superfamily, is a critical modulator of inflammation and plays a key role in controlling the cytokine cascade that drives the inflammatory response. However, the role of activin A in inflammatory
Yoshinori Takei +8 more
doaj +1 more source
npj Breast Cancer, 2015 Background:Activins belong to the transforming growth factor-β (TGF-β) superfamily of cytokines. Although the role of TGF-β in cancer progression has been highly advocated, the role of activin signaling in cancer is not well known.
Mohsin Bashir +3 more
semanticscholar +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Preeclampsia (PE) is an obstetric disease that is characterized by reduced migration and invasion of placental trophoblast cells. Here, the effects of the E3 ubiquitin ligase UBE3A on the migration and invasion of trophoblast cells were evaluated.
Xiu‐Jun Li +5 more
wiley +1 more source
Role for TGF-beta superfamily signaling in telencephalic GABAergic neuron development. [PDF]
, 2010 Signaling mechanisms mediated by the Transforming Growth Factor-beta (TGF-beta) superfamily regulate a variety of developmental processes. Here we show that components of both bone morphogenetic protein/growth differentiation factor and TGF-beta/activin ...
Lee, Amie Y +4 more
core
Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor (TGF ) signaling is essential for testicular aging and regulating testis size [PDF]
, 2013 Follistatin-like 3 (FSTL3) is a glycoprotein that binds and inhibits the action of TGFβ ligands such as activin. The roles played by FSTL3 and activin signaling in organ development and homeostasis are not fully understood.
Abir Mukherjee +54 more
core +1 more source
Parkinson's Disease Patient‐Specific Striatum Organoids Show Hallmarks of Increased Inflammation
Movement Disorders, EarlyView.Abstract Background Dopaminergic neurons from the substantia nigra pars compacta project their axons into the dorsal striatum, forming the nigrostriatal pathway. In Parkinson's disease (PD), dopaminergic terminals degenerate in the striatum, leading to dopamine depletion, which in turn causes alterations in the basal ganglia circuits that are essential
Kyriaki Barmpa +11 more
wiley +1 more source
Medical Journal of BabylonBackground: From early gestation the human trophoblast secretes large amounts of inhibin A and activin A, and their measurement provides a value for predicting the outcome in women who become pregnant after assisted reproductive techniques.
Sarah Khalid Abdulrazaq +1 more
doaj +1 more source