Results 161 to 170 of about 14,689 (206)

Theoretical-Experimental Analysis to Elucidate the Mechanism of Action of Novel Anabolic Agents. [PDF]

Molecules
Quiroga I, Cardenas-Garcia M, Hernández-Linares MG, Guerrero-Luna G, Flores-Manuel F.   +4 more
europepmc   +1 more source

Activin A-Activated ALK4 Induces Pathogenic Th17-Involved Endothelial-Mesenchymal Transition in Systemic Lupus Erythematosus-Associated Pulmonary Arterial Hypertension. [PDF]

Arthritis Rheumatol
Jing S, Qian J, Ying H, Mao P, Yao M, Wu Z, Bogaard HJ, Wang L, Li M, Yang J.   +9 more
europepmc   +1 more source

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Activin isoforms signal through type I receptor serine/threonine kinase ALK7

Molecular and Cellular Endocrinology, 2004
Activins play a fundamental role in cell differentiation and development. Activin A signaling is mediated through a combination of activin type II receptors (ActRIIs) and the activin type IB receptor, ALK4. Signaling receptors of other activin isoforms remain to be elucidated. Here, we found that activin AB and activin B are ligands for ALK7.
Osamu Hashimoto, Kunihiro Tsuchida, Masashi Nakatani   +2 more
exaly   +4 more sources

Truncated Activin Type II Receptors Inhibit Activin Bioactivity by the Formation of Heteromeric Complexes with Activin Type I Receptors

Experimental Cell Research, 1996
Truncated activin type II receptors have been reported to inhibit activin receptor signaling in Xenopus embryos, although the mechanism of action for this effect has not been fully understood. In the present study we demonstrate that in P19 embryonal carcinoma cells both the induction of the activin responsive 3TP-lux reporter construct and the ...
de Winter, J. P., de Vries, C. J., van Achterberg, T. A., Ameerun, R. F., Feijen, A., Sugino, H., de Waele, P., Huylebroeck, D., Verschueren, K., van den Eijden-van Raaij, A. J.   +9 more
openaire   +2 more sources

Genomic Organization of a Mouse Type I Activin Receptor

Biochemical and Biophysical Research Communications, 1995
We have characterized the genomic organization of a mouse type I activin receptor. Using the mouse tsk7L cDNA, 4 overlapping lambda clones containing the activin receptor IA (ActRIA) gene were isolated from a mouse 129 Sv genomic library. The mouse ActRIA gene is encoded by 10 exons and spans approximately 40 kb.
J, Schmitt, R, Mielke, H, Schrewe
openaire   +2 more sources

Immunolocalization of Type I or Type II Activin Receptors in the Rat Brain

Journal of Neuroendocrinology, 1997
We have studied immunolocalization of activin receptors in the central nervous system using polyclonal antibodies (IgG) to type I (50–55 kDa, ActRI), type II (70–75 kDa, ActRII) or a subtype of type II known as type IIB (ActRIIB) receptors of activin. A total of 7 antisera to rat activin receptors was generated, i.e.
M, Funaba, T, Murata, H, Fujimura, E, Murata, M, Abe, K, Torii   +5 more
openaire   +2 more sources

Determination of Type I Receptor Specificity by the Type II Receptors for TGF-β or Activin

Science, 1993
Transforming growth factor-β (TGF-β) and activin signal primarily through interaction with type I and type II receptors, which are transmembrane serine-threonine kinases. Tsk 7L is a type I receptor for TGF-β and requires coexpression of the type II TGF-β receptor for ligand binding.
R, Ebner, R H, Chen, S, Lawler, T, Zioncheck, R, Derynck   +4 more
openaire   +2 more sources

Characterization of Type I Receptors for Transforming Growth Factor-β and Activin

Science, 1994
Transforming growth factor-β (TGF-β) and activin exert their effects by binding to heteromeric complexes of type I and type II receptors. The type II receptors for TGF-β and activin are transmembrane serine-threonine kinases; a series of related receptors, denoted activin receptor-like kinase (ALK) 1 to 5, have recently been identified, and ALK-6 is ...
P, ten Dijke, H, Yamashita, H, Ichijo, P, Franzén, M, Laiho, K, Miyazono, C H, Heldin   +6 more
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Molecular cloning of activin type I and type II receptors and differential regulation of their expression by activin in grass carp pituitary cells

General and Comparative Endocrinology, 2010
Activins, like other members of the transforming growth factor-beta superfamily, signal via two structurally related transmembrane serine/threonine kinase receptors classified as types II and I. Two cDNAs encoding activin type IIB receptor (ActRIIB) and activin type IB receptor (ActRIB) were cloned and characterized from grass carp. The deduced ActRIIB
Chunlei, Song, Xinyan, Wang, Hong, Zhou
openaire   +2 more sources