Results 171 to 180 of about 14,689 (206)

Cloning of a Second Type of Activin Receptor and Functional Characterization in Xenopus Embryos

Science, 1992
A complementary DNA coding for a second type of activin receptor (ActRIIB) has been cloned from Xenopus laevis that fulfills the structural criteria of a transmembrane protein serine kinase. Ectodermal explants from embryos injected with activin receptor RNA show increased sensitivity to activin, as measured by the ...
L S, Mathews, W W, Vale, C R, Kintner
openaire   +2 more sources

Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

Cell, 1993
Transforming growth factor beta (TGF beta) and activin each bind to pairs of membrane proteins, known as receptor types I and II, that associate to form a signaling complex. We report that TSR-I and ActR-I, two human transmembrane serine/threonine kinases distantly related to TGF beta and activin type II receptors, act as type I receptors for these ...
L, Attisano, J, Cárcamo, F, Ventura, F M, Weis, J, Massagué, J L, Wrana   +5 more
openaire   +2 more sources

A Xenopus type I activin receptor mediates mesodermal but not neural specification during embryogenesis

Development, 1997
ABSTRACT Activins and other ligands in the TGFb superfamily signal through a heteromeric complex of receptors. Disruption of signaling by a truncated type II activin receptor, XActRIIB (previously called XAR1), blocks mesoderm induction and promotes neuralization in Xenopus embryos.
C, Chang, P A, Wilson, L S, Mathews, A, Hemmati-Brivanlou   +3 more
openaire   +2 more sources

The Role of Activin Type I Receptors in Activin A-Induced Growth Arrest and Apoptosis in Mouse B-Cell Hybridoma Cells

Cellular Signalling, 1998
Activins transduce their signals by binding to activin type I receptors and activin type II receptors, both of which contain a serine/threonine kinase domain. In this study, we established stable transfectants expressing two types of activin receptors, ActRI and ActRIB, to clarify the role of these receptors in activin signalling for growth inhibition ...
O, Hashimoto, K, Yamato, T, Koseki, M, Ohguchi, A, Ishisaki, H, Shoji, T, Nakamura, Y, Hayashi, H, Sugino, T, Nishihara   +9 more
openaire   +2 more sources

Expression of activin receptors type I and II only partially overlaps in the nervous system

NeuroReport, 1995
In situ hybridization was used to localize mRNA encoding two cooperative serine/threonine kinase receptors. Activin receptor IIA mRNA in the adult rat brain is highly expressed in the dentate gyrus, in the pyramidal neurones of CA3 and CA1, in the entorhinal cortex, in the cortical amygdaloid nucleus and in the amygdalohippocampal area.
H, Bengtsson, S, Söderström, T, Ebendal   +2 more
openaire   +2 more sources

MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4

Blood, 2008
MicroRNAs have been suggested to modulate a variety of cellular events. Here we report that miR-24 regulates erythroid differentiation by influencing the expression of human activin type I receptor ALK4 (hALK4). Ectopic expression of miR-24 reduces the mRNA and protein levels of hALK4 by targeting the 3′-untranslated region of hALK4 mRNA and interferes
Qiang, Wang, Zheng, Huang, Huiling, Xue, Chengcheng, Jin, Xiu-Li, Ju, Jing-Dong J, Han, Ye-Guang, Chen   +6 more
openaire   +2 more sources

Expression of the human activin type I and II receptor extracellular domains in Pichia pastoris

Protein Expression and Purification, 2006
Methods for the expression in Pichia pastoris and purification of the human activin receptor type I and II extracellular domains (ARIa/ARIb-ECDs, ARIIA/ARIIB-ECDs) are described. Key experimental aspects are also documented of the vector transformation methodology and the binding characteristics of these ECDs with activin A and inhibin.
Rachel, Daly, Milton T W, Hearn
openaire   +2 more sources

Identification, expression and functional analysis of activin type I receptor in common Chinese Cuttlefish, Sepiella japonica

Animal Reproduction Science, 2022
Activin, a member of the transforming growth factor-β(TGF-β) superfamily, exerts its actions by binding to specific transmembrane serine/threonine kinase receptors, known as types II and I receptors. In this study, a full-length cDNA encoding for activin type Ⅰ receptor (SjActRⅠ) was cloned, characterized, and functionally studied in S.japonica.
Liqin, Liu, Shijie, Zhao, Zhenming, Lü, Zan, Pang, Bingjian, Liu, Li, Gong, , Yinghui-Dong   +6 more
openaire   +2 more sources

Regulation of Activin Type‐II Receptor mRNA Levels in Rat Hypothalamus by Estradiol in vivo

Journal of Neuroendocrinology, 1996
A solution‐hybridization S1‐nuclease protection assay was used to evaluate the expression of messenger RNAs for the activin βA subunit and type II activin receptor in adult rat brain. Results indicate the presence of βA subunit mRNA in both hypothalamus and brainstem, with approximately two‐fold higher levels in brainstem.
V L, Trudeau, L, Pope, J P, de Winter, R J, Haché, L P, Renaud   +4 more
openaire   +2 more sources

Two Activin Type 2B Receptors from Sea Bream Function Similarly in vitro

The Biological Bulletin, 2016
Myostatin (MSTN) and activin are members of the transforming growth factor-β superfamily. Both signal through the activin type II receptors (ActRII and ActRIIB). In a previous report, we demonstrated that fish possess at least 2 genes for ActRIIB: ActRIIB-1 and ActRIIB-2, which differ in their amino acid sequence. We also showed that affinity-purified,
Elisabeth, Nadjar-Boger, Ekaterina, Krol, Bruria, Funkenstein   +2 more
openaire   +2 more sources