Results 11 to 20 of about 32,974 (249)

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Myostatin/Activin-A Signaling in the Vessel Wall and Vascular Calcification

Cells, 2021
A current hypothesis is that transforming growth factor-β signaling ligands, such as activin-A and myostatin, play a role in vascular damage in atherosclerosis and chronic kidney disease (CKD).
Pasquale Esposito, Daniela Verzola, Daniela Picciotto, Leda Cipriani, Francesca Viazzi, Giacomo Garibotto   +5 more
doaj   +1 more source

Truncated Activin Type I Receptor Alk4 Isoforms Are Dominant Negative Receptors Inhibiting Activin Signaling [PDF]

Molecular Endocrinology, 2000
Activin, a member of the transforming growth factor beta (TGFbeta) superfamily of cytokines, inhibits cell proliferation in a variety of cell types. The functions of activin are mediated by type I and type II serine/threonine kinase receptors. The main type I receptor mediating activin signaling in human cells is ActRIB, also called Alk4.
Y, Zhou, H, Sun, D C, Danila, S R, Johnson, D P, Sigai, X, Zhang, A, Klibanski   +6 more
openaire   +3 more sources

Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors. [PDF]

PLoS Biology, 2004
Members of the EGF-CFC family play essential roles in embryonic development and have been implicated in tumorigenesis. The TGFbeta signals Nodal and Vg1/GDF1, but not Activin, require EGF-CFC coreceptors to activate Activin receptors.
Simon K Cheng, Felix Olale, Ali H Brivanlou, Alexander F Schier   +3 more
doaj   +1 more source

Human activin-A is expressed in the atherosclerotic lesion and promotes the contractile phenotype of smooth muscle cells [PDF]

, 1999
Activin is a member of the transforming growth factor-beta superfamily, and it modulates the proliferation and differentiation of various target cells. In this study, we investigated the role of activin in the initiation and progression
Achterberg, T.A.E. (Tanja) van, Aken, B.E. (Benien) van, Engelse, M.A. (Marten), Neele, J.M., Pannekoek, H. (Hans), Schaik, R.H.N. (Ron) van, Vries, C.J.M. (Carlie) de   +6 more
core   +3 more sources

Activins and Activin Receptors in Cell Growth

Experimental Biology and Medicine, 1997
Activin and inhibin, members of transforming growth factor-beta (TGFbeta) superfamily, have diverse and widespread effects within living organisms at many stages during growth and development. From the initial isolation of these growth factors based on their effects of FSH secretion, the study of these factors, as well as of the activin-binding protein
S Y, Ying, Z, Zhang, B, Furst, Y, Batres, G, Huang, G, Li   +5 more
openaire   +2 more sources

Acute Modulation of Synaptic Plasticity of Pyramidal Neurons by Activin in Adult Hippocampus

Frontiers in Neural Circuits, 2014
Activin A is known as a neuroprotective factor produced upon acute excitotoxic injury of the hippocampus (in pathological states). We attempt to reveal the role of activin as a neuromodulator in the adult male hippocampus under physiological conditions ...
Yoshitaka eHasegawa, Hideo eMukai, Hideo eMukai, Hideo eMukai, Hideo eMukai, Makoto eAsashima, Yasushi eHojo, Yasushi eHojo, Yasushi eHojo, Muneki eIkeda, Yoshimasa eKomatsuzaki, Yuuki eOoishi, Suguru eKawato, Suguru eKawato, Suguru eKawato, Suguru eKawato   +15 more
doaj   +1 more source

Activin B can signal through both ALK4 and ALK7 in gonadotrope cells

Reproductive Biology and Endocrinology, 2006
Background Activins stimulate pituitary FSH synthesis via transcriptional regulation of the FSHbeta subunit gene (Fshb). Like other members of the TGFbeta superfamily, these ligands signal through complexes of type I and type II receptor serine/threonine
Lee Katharine B, Bernard Daniel J, Santos Michelle M   +2 more
doaj   +1 more source

Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors

Biomolecules, 2020
Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the SMAD2/3 pathway.
Oddrun Elise Olsen, Hanne Hella, Samah Elsaadi, Carsten Jacobi, Erik Martinez-Hackert, Toril Holien   +5 more
doaj   +1 more source