Activin A promotes neuronal differentiation of cerebrocortical neural progenitor cells. [PDF]
PLoS ONE, 2012 BACKGROUND: Activin A is a protein that participates principally in reproductive functions. In the adult brain, Activin is neuroprotective, but its role in brain development is still elusive.
Griselda Rodríguez-Martínez +2 more
doaj +1 more source
Activin receptor patterning of foregut organogenesis [PDF]
Genes & Development, 2000 Foregut development produces a characteristic sequence of gastrointestinal and respiratory organs, but the signaling pathways that ensure this developmental order remain largely unknown. Here, mutations of activin receptors ActRIIA and ActRIIB are shown to disrupt the development of posterior foregut-derived organs, including the stomach, pancreas, and
S K, Kim +7 more
openaire +2 more sources
Activin signaling as an emerging target for therapeutic interventions
Cell Communication and Signaling, 2009 After the initial discovery of activins as important regulators of reproduction, novel and diverse roles have been unraveled for them. Activins are expressed in various tissues and have a broad range of activities including the regulation of gonadal ...
Ageta Hiroshi +6 more
doaj +1 more source
A paracrine activin A–mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming
EMBO Molecular Medicine, 2020 Cancer‐associated fibroblasts (CAFs) are key regulators of tumorigenesis and promising targets for next‐generation therapies. We discovered that cancer cell‐derived activin A reprograms fibroblasts into pro‐tumorigenic CAFs.
Michael Cangkrama +9 more
doaj +1 more source
Growth differentiation factor 9 (GDF9) suppresses follistatin and follistatin-like 3 production in human granulosa-lutein cells. [PDF]
PLoS ONE, 2011 We have demonstrated that growth differentiation factor 9 (GDF9) enhances activin A-induced inhibin β(B)-subunit mRNA levels in human granulosa-lutein (hGL) cells by regulating receptors and key intracellular components of the activin signaling pathway ...
Feng-Tao Shi +3 more
doaj +1 more source
Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer. [PDF]
, 2015 BackgroundUnderstanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics.
Akagi, Naomi +9 more
core +2 more sources
Activin receptor-like kinase-2 inhibits activin signaling by blocking the binding of activin to its type II receptor [PDF]
Journal of Endocrinology, 2007 Activin receptor-like kinase-2 (Alk2) has been shown to be a promiscuous type I receptor for the transforming growth factor β (TGFβ) family of growth and differentiation factors, such as activin, bone morphogenetic proteins, and Müllerian inhibiting substance (MIS).
Nina, Renlund +4 more
openaire +2 more sources
Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development. [PDF]
PLoS ONE, 2013 The developing testis provides an environment that nurtures germ cell development, ultimately ensuring spermatogenesis and fertility. Impacts on this environment are considered to underlie aberrant germ cell development and formation of germ cell tumour ...
Denise C Miles +6 more
doaj +1 more source
Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics [PDF]
Endocrinology and Metabolism, 2021 Sarcopenia is a disease characterized by age-related decline of skeletal muscle mass and function. The molecular mechanisms of the pathophysiology of sarcopenia form a complex network due to the involvement of multiple interconnected signaling pathways ...
Jong Hyeon Yoon, Ki-Sun Kwon
doaj +1 more source
Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia. [PDF]
, 2003 BACKGROUND\ud \ud Mutations of the transforming growth factor beta (TGFbeta) receptor components ENDOGLIN and ALK-1 cause the autosomal dominant vascular disorder hereditary haemorrhagic telangiectasia (HHT).
Harrison, R E +16 more
core +1 more source