Results 71 to 80 of about 8,029 (232)

Identification of novel genes regulating the development of the palate

Developmental Dynamics, EarlyView.
Abstract Background The International Mouse Phenotyping Consortium (IMPC) has generated thousands of knockout mouse lines, many of which exhibit embryonic or perinatal lethality. Using micro‐computed tomography (micro‐CT), the IMPC has created and publicly released three‐dimensional image data sets of embryos from these lethal and subviable lines.
Ashwin Bhaskar, Sophie Astrof
wiley   +1 more source

TGF-β signaling in lymphatic vascular vessel formation and maintenance

Frontiers in Physiology, 2022
Transforming growth factor (TGF)-β and its family members, including bone morphogenetic proteins (BMPs), nodal proteins, and activins, are implicated in the development and maintenance of various organs. Here, we review its role in the lymphatic vascular
Fumiko Itoh, Tetsuro Watabe
doaj   +1 more source

The mechanical stimulation of myotubes counteracts the effects of tumor-derived factors through the modulation of the activin/follistatin ratio [PDF]

, 2019
Activin negatively affects muscle fibers and progenitor cells in aging (sarcopenia) and in chronic diseases characterized by severe muscle wasting (cachexia). High circulating activin levels predict poor survival in cancer patients. However, the relative
Adamo, Sergio, Baccam, Alexandra, Benoni-Sviercovich, Alexandra, Coletti, Dario, Li, Zhenlin, Moresi, Viviana, Rocchi, Marco, Seelaender, Marilia, Xue, Zhigang   +8 more
core   +1 more source

Cripto forms a complex with activin and type II activin receptors and can block activin signaling [PDF]

Proceedings of the National Academy of Sciences, 2003
Activin, nodal, Vg1, and growth and differentiation factor 1 are members of the transforming growth factor β superfamily and signal via the activin type II (ActRII/IIB) and type I (ALK4) serine/threonine kinase receptors. Unlike activins, however, signaling by nodal, Vg1, and growth and differentiation factor 1 requires a coreceptor from the epidermal ...
Peter C, Gray, Craig A, Harrison, Wylie, Vale   +2 more
openaire   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Loss of growth differentiation factor 9 causes an arrest of early folliculogenesis in zebrafish-A novel insight into its action mechanism.

PLoS Genetics, 2022
Growth differentiation factor 9 (GDF9) was the first oocyte-specific growth factor identified; however, most information about GDF9 functions comes from studies in the mouse model.
Weiting Chen, Yue Zhai, Bo Zhu, Kun Wu, Yuqin Fan, Xianqing Zhou, Lin Liu, Wei Ge   +7 more
doaj   +1 more source

Cancer Treatment and Bone Health [PDF]

, 2018
Considerable advances in oncology over recent decades have led to improved survival, while raising concerns about long-term consequences of anticancer treatments.
A Falahati-Nini, A Garg, A Lipton, A Llombart, A Morishima, A Tomkinson, AM Brufsky, AR Hong, B Buehring, BF Boyce, BL Clarke, BL Clarke, C Christensen, C Magno, C Poznak Van, C Shapiro, C Wilson, Catherine Handforth, CH Kasperk, CJ Stava, D Goldray, D Vanderschueren, DA Cameron, DA Galvão, DL Hershman, DM Huber, DS Perrien, Early Breast Cancer Trialists, EP Smith, F Mazzuca, FA Trémollieres, GK Ellis, HG Bone, HW Daniell, I Fogelman, I Sestak, J Morote, J Pfeilschifter, J Planas, Janet Brown, JD Wilson, JE Lester, JE Lester, JF Forbes, JL Mohler, JM Bruder, KB Emerton, KM Nicks, L Bošković, L Vehmanen, LC Hofbauer, LC Hofbauer, LH Klotz, LP Fried, M Bauer, M Datta, M Gnant, M Gnant, M Kalder, M Kalder, M Rabaglio, MD Michaelson, MG Oefelein, MM Agarwal, MR Smith, MR Smith, MR Smith, MR Smith, MR Smith, MR Smith, N Majithia, N Napoli, ND James, ND Wagner-Johnston, P Hadji, P Hadji, P Hadji, P Hadji, P Rodrigues, PD Miller, PE Goss, PE Goss, PL Nguyen, R Choo, R Coleman, R Coleman, R Eastell, R Eastell, R Soleimani, RA Adler, RE Coleman, RJ Segal, Robert Coleman, S Dhesy-Thind, S D’Oronzo, SL Greenspan, Stella D’Oronzo, SY Ying, T Kameda, T Liu, T Rana, T Saarto, TA Guise, TH Diamond, TJ Powles, V Carnevale, V Subbiah, VB Shahinian, W Vale, WJ Boyle   +109 more
core   +2 more sources

Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension

Scientific Reports, 2022
Sotatercept is an activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein that improves cardiopulmonary function in patients with pulmonary arterial hypertension (PAH) by selectively trapping activins and growth differentiation factors.
Sachindra R. Joshi, Jun Liu, Troy Bloom, Elif Karaca Atabay, Tzu-Hsing Kuo, Michael Lee, Elitza Belcheva, Matthew Spaits, Rosa Grenha, Michelle C. Maguire, Jeffrey L. Frost, Kathryn Wang, Steven D. Briscoe, Mark J. Alexander, Brantley R. Herrin, Roselyne Castonguay, R. Scott Pearsall, Patrick Andre, Paul B. Yu, Ravindra Kumar, Gang Li   +20 more
doaj   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

HE4 in the differential diagnosis of ovarian masses [PDF]

, 2015
Ovarian masses, a common finding among pre- and post-menopausal women, can be benign or malignant. Ovarian cancer is the leading cause of death from gynecologic malignancy among women living in industrialized countries.
ANASTASI, Emanuela, ANGELONI, Antonio, Flavia Longo, MANGANARO, Lucia, PORPORA, Maria Grazia, Teresa Granato   +5 more
core   +1 more source