Results 151 to 160 of about 10,778,046 (183)

Differential regulation of activity-dependent neuroprotective protein in rat astrocytes by VIP and PACAP

Regulatory Peptides, 2004
Activity-dependent neuroprotective protein (ADNP) was shown to be a vasoactive intestinal peptide (VIP) responsive gene in astrocytes derived from the cerebral cortex of newborn rats. The present study was set out to identify VIP receptors that are associated with increases in ADNP expression in developing astrocytes.
Illana Gozes, Margalit Zusev
exaly   +3 more sources

The role of activity-dependent neuroprotective protein in a mouse model of fetal alcohol syndrome

American Journal of Obstetrics and Gynecology, 2003
Fetal alcohol syndrome (FAS) is the most common nongenetic cause of mental retardation. Peptides NAPVSIPQ (NAP) and SALLRSIPA (SAL), related to activity-dependent neuroprotective protein (ADNP), prevent alcohol-induced damage in a mouse model of FAS. Our objective was to characterize ADNP in this model to relate this protein to the mechanisms of damage
Douglas E Brenneman, Daniel Abebe, Sarah H Poggi   +2 more
exaly   +3 more sources

NAP, a Peptide Derived from the Activity-Dependent Neuroprotective Protein, Modulates Macrophage Function

Annals of the New York Academy of Sciences, 2006
Abstract: NAP is an eight‐amino acid neuroprotective peptide NAPVSIPQ; it is the smallest active element derived from the recently cloned activity‐dependent neuroprotective protein (ADNP). NAP readily enters the brain from the blood. It will be important to learn whether NAP, in addition to its neuroprotective activity, also might influence immune ...
Francisco J. Quintana, Illana Gozes, David Pozo   +2 more
exaly   +3 more sources

Activity-dependent neuroprotective protein: a novel gene essential for brain formation

Developmental Brain Research, 2003
We have recently cloned the novel homeobox-containing activity-dependent neuroprotective protein (ADNP). In the current study, mouse ADNP was shown to be expressed at the time of neural tube closure, detected at E7.5 and increased on E9.5. Expression was augmented in the brain (E12.5), sustained throughout embryogenesis and regulated by VIP.
Albert Pinhasov, Illana Gozes, Douglas E Brenneman   +2 more
exaly   +3 more sources

Differential expression of embryonic and maternal activity-dependent neuroprotective protein during mouse development

American Journal of Obstetrics and Gynecology, 2002
Activity-dependent neuroprotective protein (ADNP) potently enhances the survival of neurons and is regulated by vasoactive intestinal peptide, which also mediates postimplantation mouse embryonic growth. The objective of this study was to characterize ADNP in mouse embryonic tissues throughout development.Developmental tissues (embryo, decidua ...
Albert Pinhasov, Illana Gozes, Douglas E Brenneman   +2 more
exaly   +3 more sources

Activity-dependent neuroprotective protein (ADNP) expression level is correlated with the expression of the sister protein ADNP2: Deregulation in schizophrenia

European Neuropsychopharmacology, 2011
Activity-dependent neuroprotective protein (ADNP) and the homologous protein ADNP2 provide cell protection. ADNP is essential for brain formation, proper brain development and neuronal plasticity, all reported to be impaired in the schizophrenia patient brains.
Illana Gozes, Galila Agam
exaly   +3 more sources

A Novel Signaling Molecule for Neuropeptide Action: Activity‐dependent Neuroprotective Protein

Annals of the New York Academy of Sciences, 1999
Abstract:The complete coding sequence of a novel protein (828 amino acids, pI 5.99), a potential new mediator of vasoactive intestinal peptide (VIP) activity was recently revealed. The expression of this molecule, activity‐dependent neuroprotective protein (ADNP), was augmented in the presence of VIP, in cerebral cortical astrocytes.
I, Gozes, M, Bassan, R, Zamostiano, A, Pinhasov, A, Davidson, E, Giladi, O, Perl, G W, Glazner, D E, Brenneman   +8 more
openaire   +2 more sources

Activity-Dependent Neuroprotective Protein Modulates Its Own Gene Expression

Journal of Molecular Neuroscience, 2011
We investigated whether activity-dependent neuroprotective protein (ADNP) could autoregulate its own expression. Both the endogenous ADNP gene and reporter gene constructs were analysed in response to overexpression of ADNP, supplied either as wild-type ADNP or a mutant form lacking the NAP motif, a motif which has neuroprotective properties ...
Moutasem S, Aboonq, Sylvia A, Vasiliou, Kate, Haddley, John P, Quinn, Vivien J, Bubb   +4 more
openaire   +2 more sources

Sexual dimorphism of activity-dependent neuroprotective protein in the mouse arcuate nucleus

Neuroscience Letters, 2004
Activity-dependent neuroprotective protein (ADNP) is a highly conserved vasoactive intestinal peptide (VIP) responsive gene that is expressed abundantly in the brain and in the body and is essential for brain formation and embryonic development. Since, VIP exhibits sexual dimorphism in the hypothalamus, the potential differential expression of ADNP in ...
Sharon, Furman, Joanna M, Hill, Inna, Vulih, Roy, Zaltzman, Janet M, Hauser, Douglas E, Brenneman, Illana, Gozes   +6 more
openaire   +2 more sources

Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes

Nature, 2018
De novo mutations in ADNP, which encodes activity-dependent neuroprotective protein (ADNP), have recently been found to underlie Helsmoortel-Van der Aa syndrome, a complex neurological developmental disorder that also affects several other organ functions 1 .
Ostapcuk V, Mohn F, Carl SH, Basters A, Hess D, Iesmantavicius V, Lampersberger L, Flemr M, Pandey A, Thomä NH, Betschinger J, Bühler M   +11 more
openaire   +3 more sources