Results 11 to 20 of about 10,778,046 (183)

Cloning and Characterization of the Human Activity-dependent Neuroprotective Protein [PDF]

Journal of Biological Chemistry, 2001
We have recently cloned the mouse activity-dependent neuroprotective protein (ADNP). Here, we disclose the cloning of human ADNP (hADNP) from a fetal brain cDNA library. Comparative sequence analysis of these two ADNP orthologs indicated 90% identity at the mRNA level. Several single nucleotide polymorphic sites were noticed.
Zamostiano, R., Pinhasov, A., Gelber, E., Steingart, R., Seroussi, E., Giladi, E., Bassan, M., Wollman, Y., Eyre, H., Mulley, J., Brenneman, D., Gozes, I.   +11 more
openaire   +4 more sources

Diminished activity-dependent neuroprotective protein (ADNP) contributes to complement gene elevation in Alzheimer's disease. [PDF]

J Alzheimers Dis
Background Gene dysregulation is one of the key mechanisms that link pathological abnormalities to cognitive impairment in Alzheimer's disease (AD), the most prevalent neurodegenerative disorder. Our transcriptomic analysis of large-scale postmortem AD human prefrontal cortex (PFC) data revealed that complement ...
Ren Y, Saleem K, Patel PJ, Lee YH, Feng J, Yan Z.   +5 more
europepmc   +3 more sources

Regulation of activity-dependent neuroprotective protein (ADNP) by the NO-cGMP pathway in the hippocampus during kainic acid-induced seizure

Neurobiology of Disease, 2008
Activity-dependent neuroprotective protein (ADNP) is widely distributed in the cytoplasm of neurons and astrocytes of the hippocampus. Kainic acid (KA)-induced seizures increases neuronal nitric oxide synthase (nNOS) in neurons and inducible NOS (iNOS ...
Anna S. Cosgrave, Jennifer S. McKay, Vivien Bubb, Richard Morris, John P. Quinn, Thimmasettappa Thippeswamy   +5 more
doaj   +3 more sources

The Role of p53 Protein in the Realization of the Exogenous Heat Shock Protein 70 Anti-Apoptotic Effect during Axotomy

Cells, 2021
The search for effective neuroprotective agents for the treatment of neurotrauma has always been of great interest to researchers around the world. Extracellular heat shock protein 70 (eHsp70) is considered a promising agent to study, as it has been ...
Svetlana V. Demyanenko, Maria A. Pitinova, Valentina A. Dzreyan, Yuliya N. Kalyuzhnaya, Moez A. Eid, Andrey Y. Abramov, Michael B. Evgen’ev, David G. Garbuz   +7 more
doaj   +1 more source

Subcellular localization and secretion of activity-dependent neuroprotective protein in astrocytes [PDF]

Neuron Glia Biology, 2004
Activity-dependent neuroprotective protein (ADNP, ∼123562.8 Da), is synthesized in astrocytes and expression of ADNP mRNA is regulated by the neuroprotective peptide vasoactive intestinal peptide (VIP). The gene that encodes ADNP is conserved in human, rat and mouse, and contains a homeobox domain profile that includes a nuclear-export signal and a ...
Sharon, Furman, Ruth A, Steingart, Shmuel, Mandel, Janet M, Hauser, Douglas E, Brenneman, Illana, Gozes   +5 more
openaire   +2 more sources

Proximity labeling identifies a repertoire of site-specific R-loop modulators

Nature Communications, 2022
R-loops are three-stranded nucleic acid structures that contribute to genome instability and accumulate in neurological diseases. Here the authors identify R-loop proximal factors, which are enriched for zinc finger and homeodomain proteins, including ...
Qingqing Yan, Phillip Wulfridge, John Doherty, Jose L. Fernandez-Luna, Pedro J. Real, Hsin-Yao Tang, Kavitha Sarma   +6 more
doaj   +1 more source

ADNP Upregulation Promotes Bladder Cancer Cell Proliferation via the AKT Pathway

Frontiers in Oncology, 2020
BackgroundActivity-dependent neuroprotective protein (ADNP), which is involved in embryonic development and neurogenesis, has been proven to be upregulated in some human tumors.
Shuai Zhu, Zhenzhou Xu, Yong Zeng, Ying Long, Gang Fan, Qi Ding, Yuheng Wen, Jian Cao, Tao Dai, Weiqing Han, Yu Xie   +10 more
doaj   +1 more source

Aronia juice improves working memory and suppresses δ-secretase activity in 5XFAD mice

NFS Journal, 2023
Asparagine endopeptidase (AEP) cleaves amyloid precursor protein to facilitate amyloid β (Aβ) production in the brain. Aronia berry (Aronia melanocarpa) has various beneficial effects on health through inhibition of enzymes such as dipeptidyl peptidase ...
Takuya Yamane, Momoko Imai, Satoshi Handa, Hideo Ihara, Tatsuji Sakamoto, Tetsuo Ishida, Takenori Nakagaki, Susumu Uchiyama   +7 more
doaj   +1 more source

Elucidating the role of DEPTOR in Alzheimer's disease [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.The mammalian or mechanistic target of rapamycin (mTOR) is a Ser/Thr protein kinase that, in response to nutrient stimulation, regulates cellular growth, proliferation ...
Karteris, E, Zachariades, E, Rogers-Broadway, K-R, Davies, J   +3 more
core   +7 more sources

Amyloid β-Oligomers Inhibit the Nuclear Ca²⁺ Signals and the Neuroprotective Gene Expression Induced by Gabazine in Hippocampal Neurons

Antioxidants, 2023
Hippocampal neuronal activity generates dendritic and somatic Ca2+ signals, which, depending on stimulus intensity, rapidly propagate to the nucleus and induce the expression of transcription factors and genes with crucial roles in cognitive functions ...
Pedro Lobos, Ignacio Vega-Vásquez, Barbara Bruna, Silvia Gleitze, Jorge Toledo, Steffen Härtel, Cecilia Hidalgo, Andrea Paula-Lima   +7 more
doaj   +1 more source