Results 31 to 40 of about 10,778,046 (183)

The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK

Marine Drugs, 2017
In previous work, we characterized the strong neuroprotective properties of the marine compound Psammaplysene A (PA) in in vitro and in vivo models of neurodegeneration.
Marco Boccitto, Nayoung Lee, Satoshi Sakamoto, Lynn A. Spruce, Hiroshi Handa, Jon Clardy, Steven H. Seeholzer, Robert G. Kalb   +7 more
doaj   +1 more source

Effects of 17β-oestradiol on rat detrusor smooth muscle contractility [PDF]

, 2009
The aim of this study was to investigate the effect of 17β-oestradiol (E2) on detrusor smooth muscle contractility and its possible neuroprotective role against ischaemic-like condition, which could arise during overactive bladder disease.
Keith L. Brain, Sgaragli, G, Giampietro Sgaragli, Pessina, F, Sgaragli, G., Pessina, F., Young, John, John S. Young, Valeri, A., Young, JS, Sgaragli, GIAN PIETRO, Valeri, A, Young, J. S., Aurora Valeri, Brain, K., Brain, K. L., Pessina, Federica, Federica Pessina, Brain, Keith; id_orcid, Brain, KL   +19 more
core   +1 more source

Ubiquitin-proteasome dependent mitochondrial protein quality control [PDF]

, 2014
Dysfunctional mitochondria cause many neurodegenerative disorders and with aging in general, mechanisms of mitochondrial quality control are essential for cellular function.
Benischke, Anne-Sophie
core   +1 more source

Complete Sequence of a Novel Protein Containing a Femtomolar‐Activity‐Dependent Neuroprotective Peptide [PDF]

Journal of Neurochemistry, 1999
Abstract : The vulnerability of neurons and the irreversibility of loss make discoveries of neuroprotective compounds fundamentally important. Here, the complete coding sequence of a novel protein (828 amino acids, pl 5.99), derived from mouse neuroglial cells, is revealed.
M, Bassan, R, Zamostiano, A, Davidson, A, Pinhasov, E, Giladi, O, Perl, H, Bassan, C, Blat, G, Gibney, G, Glazner, D E, Brenneman, I, Gozes   +11 more
openaire   +2 more sources

The Eight and a Half Year Journey of Undiagnosed AD: Gene Sequencing and Funding of Advanced Genetic Testing Has Led to Hope and New Beginnings

Frontiers in Endocrinology, 2017
BackgroundActivity-dependent neuroprotective protein (ADNP) is one of the most prevalent de novo mutated genes in syndromic autism spectrum disorders, driving a general interest in the gene and the syndrome.AimThe aim of this study was to provide a ...
Illana Gozes, Marc C. Patterson, Anke Van Dijck, R. Frank Kooy, Joseph N. Peeden, Jacob A. Eichenberger, Angela Zawacki-Downing, Sandra Bedrosian-Sermone   +7 more
doaj   +1 more source

3',5'-Cyclic Adenosine Monophosphate- and Ca2+-Calmodulin-Dependent Endogenous Protein Phosphorylation Activity in Membranes of the Bovine Chromaffin Secretory Vesicles: Identification of Two Phosphorylated Components as Tyrosine Hydroxylase and Protein Kinase Regulatory Subunit Type II [PDF]

, 1983
: Membranes of the secretory vesicles from bovine adrenal medulla were investigated for the presence of the endogenous protein phosphorylation activity. Seven phosphoprotein bands in the molecular weight range of 250,000 to 30,000 were observed by means ...
Weber, W., Treiman, M., Gratzl, Manfred
core   +1 more source

Ethanol inhibits neuronal differentiation by disrupting activity-dependent neuroprotective protein signaling [PDF]

Proceedings of the National Academy of Sciences, 2008
The mechanisms by which ethanol damages the developing and adult central nervous system (CNS) remain unclear. Activity-dependent neuroprotective protein (ADNP) is a glial protein that protects the CNS against a wide array of insults and is critical for CNS development.
Suzhen, Chen, Michael E, Charness
openaire   +2 more sources

The distribution and function of GDE2, a regulator of spinal motor neuron survival, are disrupted in Amyotrophic Lateral Sclerosis

Acta Neuropathologica Communications, 2022
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects the viability of upper and lower motor neurons. Current options for treatment are limited, necessitating deeper understanding of the mechanisms underlying ALS ...
Anna Westerhaus, Thea Joseph, Alison J. Meyers, Yura Jang, Chan Hyun Na, Clinton Cave, Shanthini Sockanathan   +6 more
doaj   +1 more source

NAP and D-SAL: neuroprotection against the β amyloid peptide (1–42) [PDF]

BMC Neuroscience, 2008
Introduction NAP (Asn-Ala-Pro-Val-Ser-Ile-Pro-Gln, single amino acid letter code, NAPVSIPQ), an eight amino acid neuroprotective peptide derived from activity-dependent neuroprotective protein (ADNP), exhibits some structural similarity to activity ...
Piltzer Inbar, Divinski Inna, Gozes Illana   +2 more
doaj   +1 more source

Combination of panax ginseng and ginkgo biloba extracts attenuate cerebral ischemia injury with modulation of NLRP3 inflammasome and CAMK4/CREB pathway

Frontiers in Pharmacology, 2022
Stroke is a major cause of death and disability throughout the world. A combination of Panax Ginseng and Ginkgo biloba extracts (CGGE) is an effective treatment for nervous system diseases, but the neuroprotective mechanism underlying CGGE remains ...
Aimei Zhao, Aimei Zhao, Nan Liu, Guozhi Jiang, Li Xu, Mingjiang Yao, Yehao Zhang, Bingjie Xue, Bo Ma, Dennis Chang, Yujing Feng, Yunyao Jiang, Jianxun Liu, Guoping Zhou   +13 more
doaj   +1 more source