Results 51 to 60 of about 10,778,046 (183)

Apple Procyanidins Suppress Amyloid β-Protein Aggregation

Biochemistry Research International, 2011
Procyanidins (PCs) are major components of the apple polyphenols (APs). We previously reported that treatment with PC extended the mean lifespan of Caenorhabditis elegans (Sunagawa et al., 2011). In order to estimate the neuroprotective effects of PC, we
Toshihiko Toda, Tadahiro Sunagawa, Tomomasa Kanda, Motoyuki Tagashira, Takuji Shirasawa, Takahiko Shimizu   +5 more
doaj   +1 more source

ADNP Controls Gene Expression Through Local Chromatin Architecture by Association With BRG1 and CHD4

Frontiers in Cell and Developmental Biology, 2020
ADNP (Activity Dependent Neuroprotective Protein) is proposed as a neuroprotective protein whose aberrant expression has been frequently linked to rare neural developmental disorders and cancers, including the recently described neurodevelopmental ...
XiaoYun Sun, WenJun Yu, Li Li, YuHua Sun, YuHua Sun   +4 more
doaj   +1 more source

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies. [PDF]

PLoS Biology, 2016
Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is neuroprotective in numerous preclinical models of neurodegeneration. Here, we show that brain nmnat2 mRNA levels correlate positively with global cognitive function and negatively with AD ...
Yousuf O Ali, Hunter M Allen, Lei Yu, David Li-Kroeger, Dena Bakhshizadehmahmoudi, Asante Hatcher, Cristin McCabe, Jishu Xu, Nicole Bjorklund, Giulio Taglialatela, David A Bennett, Philip L De Jager, Joshua M Shulman, Hugo J Bellen, Hui-Chen Lu   +14 more
doaj   +1 more source

Activity-dependent Neuroprotective Protein Constitutes a Novel Element in the SWI/SNF Chromatin Remodeling Complex [PDF]

Journal of Biological Chemistry, 2007
Complete deficiency in activity-dependent neuroprotective protein (ADNP), a heterochromatin 1-binding protein, results in dramatic changes in gene expression, neural tube closure defects, and death at gestation day 9 in mice. To further understand the cellular roles played by ADNP, the HEK293 human embryonic kidney cell line that allows efficient ...
Shmuel, Mandel, Illana, Gozes
openaire   +2 more sources

GABA(A) receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein [PDF]

, 2004
GABA(A) receptors are critical in controlling neuronal activity. Here, we examined the role for phospholipase C-related inactive protein type 1 (PRIP-1), which binds and inactivates protein phosphatase 1alpha (PP1alpha) in facilitating GABA(A) receptor ...
Kanematsu, T, Terunuma, M, Jovanovic, JN, Jang, IS, Kittler, JT, Akaike, N, Nakayama, KI, Ryu, SH, Moss, SJ, Ha, SH, Hirata, M   +10 more
core  

Unexpected neuronal protection of SU5416 against 1-Methyl-4-phenylpyridinium ion-induced toxicity via inhibiting neuronal nitric oxide synthase.

PLoS ONE, 2012
SU5416 was originally designed as a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) for cancer therapy.
Wei Cui, Zaijun Zhang, Wenming Li, Shinghung Mak, Shengquan Hu, Huan Zhang, Shuai Yuan, Jianhui Rong, Tony Chunglit Choi, Simon M Y Lee, Yifan Han   +10 more
doaj   +1 more source

Anti-apoptotic Actions of Allopregnanolone and Ganaxolone Mediated Through Membrane Progesterone Receptors (PAQRs) in Neuronal Cells

Frontiers in Endocrinology, 2020
The neurosteroids progesterone and allopregnanolone regulate numerous neuroprotective functions in neural tissues including inhibition of epileptic seizures and cell death.
Peter Thomas, Yefei Pang
doaj   +1 more source

Neuroprotective effects of adipose‐derived stem cells on ferrous sulfate‐induced neurotoxicity

Brain Science Advances, 2021
Background: Ferrous ion, a degradation product of hematomas, induces inflammatory reactions and other secondary injuries after intracerebral hemorrhage (ICH).
Qian Wu, Chao Pan, Yang Hu, Gaigai Li, Shiling Chen, Jie Jing, Jingfei Yang, Zhouping Tang   +7 more
doaj   +1 more source

High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase [PDF]

, 2011
<p><b>Background:</b> <i>Leishmania</i> species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs).
Mottram Jeremy C., Thomson, Graeme, Mottram, JC, Grant Karen M., Turner, N.J., Malcolm D. Walkinshaw, Malone, Kirk, Turner, Nicholas J., Nicholas J Turner, Jeremy C. Mottram, Karen M. Grant, Walker, Roderick G., Kita, K, Graeme Thomson, Malone Kirk, Karen M Grant, Grant, Karen, Nicholas J. Turner, Walker, RG, Nowicki, Matthew W., Thomson Graeme, Walkinshaw, M.D., Walkinshaw Malcolm D., David G. Blake, David G Blake, Walker Roderick G., Brown, Elaine, Brown Elaine, Blake David G., Brown, E, Malone, K, Turner Nicholas J., Walkinshaw, MD, Blake, DG, Matthew W. Nowicki, Walker, R.G., Malone, K., Blake, David G., Elaine Brown, Mottram, J.C., Kirk Malone, Walkinshaw, Malcolm D., Matthew W Nowicki, Nowicki, MW, Brown, E., Nowicki Matthew W., Turner, Nicholas J.; id_orcid, Grant, Karen M., Grant, K.M., Mottram, Jeremy C., Roderick G Walker, Thomson, G, Jeremy C Mottram, Roderick G. Walker, Nowicki, M.W., Grant, KM, Blake, D.G., Malcolm D Walkinshaw, Turner, NJ, Thomson, G.   +59 more
core   +2 more sources

Helsmoortel-van der Aa syndrome syndrome in a patient with epilepsy, developmental delay, intellectual disability, and autism spectrum disorder

Эпилепсия и пароксизмальные состояния, 2020
Autism spectrum disorders (ASDs) are a group of complex disintegrative disorders of mental development, characterized by a lack of ability to social interaction, communication, stereotyped behavior, leading to social maladaptation.
T. V. Kozhanova, S. S. Zhilina, T. I. Mescheryakova, E. G. Luk`yanova, K. V. Osipova, S. O. Ayvazyan, A. G. Prityko   +6 more
doaj   +1 more source