Results 61 to 70 of about 10,778,046 (183)

Ligusticum chuanxiong Hort as a medicinal and edible plant foods: Antioxidant, anti-aging and neuroprotective properties in Caenorhabditis elegans

Frontiers in Pharmacology, 2022
Ligusticum chuanxiong Hort. (CX) is a medicinal and edible plant including a variety of active substances, which may be an available resource for the treatment of related diseases.
Yihan Qin, Fangfang Chen, Zizhong Tang, Hongjiao Ren, Qing Wang, Nayu Shen, Wenjie Lin, Yirong Xiao, Ming Yuan, Hui Chen, Tongliang Bu, Qingfeng Li, Lin Huang   +12 more
doaj   +1 more source

Biosensor measurement of purine release from cerebellar cultures and slices [PDF]

, 2010
We have previously described an action-potential and Ca2+-dependent form of adenosine release in the molecular layer of cerebellar slices. The most likely source of the adenosine is the parallel fibres, the axons of granule cells. Using microelectrode
Eason, Robert, Robert Eason, Dale, Nicholas, Wall, Mark J., Mark Wall, Nicholas Dale   +5 more
core   +1 more source

Expression of Activity-Dependent Neuroprotective Protein in the Immune System: Possible Functions and Relevance to Multiple Sclerosis [PDF]

Neuroimmunomodulation, 2009
<i>Background:</i> Activity-dependent neuroprotector (ADNP) is a neuroprotective molecule containing an 8-amino acid peptide, NAPVSIPQ (NAP), that is sufficient for its neuroprotective effects. <i>Objective:</i> To assess the expression of ADNP in the human immune system in normal subjects and multiple sclerosis patients.
Braitch, Manjit, Kawabe, Kiyokazu, Nyirenda, Mukanthu, Gilles, Lucie Jean, Robins, R. Adrian, Gran, Bruno, Murphy, Sean, Showe, Louise, Constantinescu, Cris S.   +8 more
openaire   +2 more sources

Activity-dependent neuroprotective protein (ADNP) exhibits striking sexual dichotomy impacting on autistic and Alzheimer’s pathologies [PDF]

Translational Psychiatry, 2015
Activity-dependent neuroprotective protein (ADNP) is a most frequent autism spectrum disorder (ASD)-associated gene and the only protein significantly decreasing in the serum of Alzheimer's disease (AD) patients. Is ADNP associated with ASD being more prevalent in boys and AD more prevalent in women?
Malishkevich, A, Amram, N, Hacohen-Kleiman, G, Magen, I, Giladi, E, Gozes, I   +5 more
openaire   +2 more sources

Modulation of neuronal plasticity by extracellular serine proteases and their inhibitors : proteolytic control of NMDA receptors [PDF]

, 2004
Serine proteases are enzymes catalyzing protein cleavage. Because of their capability to cleave a wide variety of substrates, they are involved in many critical physiological processes such as digestion, hemostasis, reproduction and immune response, as ...
Kvajo, Mirna
core   +1 more source

ADNP dysregulates methylation and mitochondrial gene expression in the cerebellum of a Helsmoortel–Van der Aa syndrome autopsy case

Acta Neuropathologica Communications
Background Helsmoortel–Van der Aa syndrome is a neurodevelopmental disorder in which patients present with autism, intellectual disability, and frequent extra-neurological features such as feeding and gastrointestinal problems, visual impairments, and ...
Claudio D’Incal, Anke Van Dijck, Joe Ibrahim, Kevin De Man, Lina Bastini, Anthony Konings, Ellen Elinck, Claudia Theys, Illana Gozes, Zlatko Marusic, Mirna Anicic, Jurica Vukovic, Nathalie Van der Aa, Ligia Mateiu, Wim Vanden Berghe, R. Frank Kooy   +15 more
doaj   +1 more source

Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase [PDF]

, 2012
eEF2K [eEF2 (eukaryotic elongation factor 2) kinase] phosphorylates and inactivates the translation elongation factor eEF2. eEF2K is not a member of the main eukaryotic protein kinase superfamily, but instead belongs to a small group of so-called ...
Hussain, Nusrat, Proud, Christopher G, Proud, C., Wang, Xuemin, Rider, M., Rider, Mark H, Pyr Dit Ruys, S., Vertommen, D., Rider, Mark, Pyr Dit Ruys, Sébastien, Herinckx, Gaëtan, Vertommen, Didier, Herinckx, G., Smith, Ewan M, Wang, X., Smith, E., Hussain, N.   +16 more
core   +1 more source

Spatiotemporal and functional characterisation of the Plasmodium falciparum cGMP-dependent protein kinase. [PDF]

, 2012
Signalling by 3'-5'-cyclic guanosine monophosphate (cGMP) exists in virtually all eukaryotes. In the apicomplexan parasite Plasmodium, the cGMP-dependent protein kinase (PKG) has previously been reported to play a critical role in four key stages of the ...
Baker, David A, Lev Solyakov (122244), Solyakov, Lev, David A Baker, Flueck, Christian, Lev Solyakov, L. Solyakov (7638338), Hopp Christine S., Flueck Christian, Andrew Tobin (122248), David A. Baker (122252), Christine S Hopp, David A. Baker, D. A. Baker (7638335), A. B. Tobin (7638326), Solyakov Lev, C. Flueck (7638332), Andrew Tobin, Christine S. Hopp (122239), Baker David A., Tobin Andrew, Christian Flueck, C. S. Hopp (7638329), Tobin, Andrew, Christian Flueck (122240), Hopp, Christine S   +25 more
core   +1 more source

The regulation of endocannabinoids after neuronal damage and the neuroprotective impact of GPR55 in organotypic hippocampal slice cultures [PDF]

, 2013
Endocannabinoids (eCB) are signaling lipids and became known for their importance in the central nervous system as well as in immune defense. Beneficial effects of eCB are shown in processes of excitotoxic lesion, secondary damage and neuronal plasticity
Kallendrusch, Sonja
core  

The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel [PDF]

, 2011
Opening of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels is facilitated by direct binding of cyclic nucleotides to a cyclic nucleotide-binding domain (CNBD) in the C-terminus. Here, we show for the first time that in the HCN2 channel
Biel Martin, Biel, Martin, Hammelmann, Verena, Hofmann, Franz, Michalakis, Stylianos, Xiangang Zong, Hammelmann Verena, Zong Xiangang, Stylianos Michalakis, Martin Biel, Franz Hofmann, Michalakis Stylianos, Hofmann Franz, Zong, Xiangang, Verena Hammelmann, Hammelmann, V;Zong, X;Hofmann, F;Michalakis, S;Biel, M   +15 more
core   +2 more sources