Results 71 to 80 of about 10,778,046 (183)

Avaliação do efeito neuroprotetor de lectinas frente à neurotoxicidade glutamatérgica [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em BioquímicaA excitotoxicidade induzida pela excessiva ativação da neurotransmissão glutamatérgica está envolvida em várias ...
Jacques, Amanda Virtuoso
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SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice.

PLoS ONE, 2016
Huntington's disease (HD) is a neurodegenerative disorder for which there are no disease-modifying treatments. SIRT1 is a NAD+-dependent protein deacetylase that is implicated in maintaining neuronal health during development, differentiation and ageing.
Raffaella Tulino, Agnesska C Benjamin, Nelly Jolinon, Donna L Smith, Eduardo N Chini, Alisia Carnemolla, Gillian P Bates   +6 more
doaj   +1 more source

Calcium-dependent serine-threonine phosphatase and autophagy inactivation mediated by Baicalein attenuates prion protein-mediated neuronal cell damage

BMC Complementary Medicine and Therapies
Background Prion diseases are a group of incurable and fatal neurodegenerative disorders characterized by neuronal cell death. Calcineurin and autophagy induce neurotoxicity by prion proteins, which may have therapeutic benefits by inhibiting calcineurin
Jeong-Min Hong, Ali Newaz Munna, Jong-Hoon Kim, Ji-Hong Moon, Jae-Won Seol, Sang-Youel Park   +5 more
doaj   +1 more source

Protein Dynamics and its Correlation to Protein Activity and Stability [PDF]

, 2009
The aim of this thesis is to investigate the role of fast protein dynamics (picosecond timescale) in enzyme activity and stability, and specifically to test the hypothesis that enzyme activity and stability are inversely related by their internal ...
Clement, David
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Neuron-targeted caveolin-1 overexpression attenuates cognitive loss and pathological transcriptome changes in symptomatic Alzheimer’s disease models

Signal Transduction and Targeted Therapy
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by progressive synaptic loss and cognitive decline. Gene therapy that augments intrinsic neuroprotective pathways offers a promising strategy to mitigate neurodegeneration
Dongsheng Wang, Andrei V. Chernov, Ryan Lam, Hongxia Wang, Wenxi Li, Xiaojing Li, Tiffany Duong, Shanshan Wang, Brian P. Head   +8 more
doaj   +1 more source

Neuritin: a multifaceted neuroprotective factor with emerging applications for neurodegeneration

Frontiers in Neuroscience
Neuritin is a conserved, activity-regulated gene encoding a glycosylphosphatidylinositol-anchored protein, crucial for neural development, synaptic plasticity, and neuroprotection.
Kai L. Mongan, Tasneem P. Sharma, Tasneem P. Sharma   +2 more
doaj   +1 more source

Estudo das Vias de Sinalização Envolvidas no Pré-condicionamento com N-Metil-D-Aspartato (NMDA) sobre Convulsões Induzidas por Ácido Quinolínico em Camundongos [PDF]

, 2008
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.O pré-condicionamento cerebral se refere a um estado de tolerância transitória do tecido nervoso a um estimulo letal evocado por um insulto moderado prévio ...
Herculano, Bruno
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The actin-binding protein profilin II in neuronal plasticity [PDF]

, 2006
Activity-dependent plasticity in neurons involves changes in synaptic transmission and connectivity. These changes lead to altered neuronal circuit properties and are thought to underlie learning and memory.
Birbach, Andreas
core   +1 more source

Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis

Developmental Biology, 2007
Complete deficiency in activity-dependent neuroprotective protein (ADNP) results in neural tube closure defects and death at days 8.5-9.5 of gestation in the mouse (E8.5-9.5). To elucidate ADNP associated pathways, Affymetrix 22,690-oligonucleotide-based microarrays were used on ADNP knockout and control mouse embryos (E9) separated completely from ...
Mandel, Shmuel, Rechavi, Gideon, Gozes, Illana   +2 more
openaire   +2 more sources

Estudo do efeito neuroprotetor da mirtazapina e imipramina e sua relação com a expressão gênica de proteínas apoptóticas [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.Neste estudo foram investigados a ação neuroprotetora dos antidepressivos mirtazapina e imipramina e os efeitos ...
Lieberknecht, Vicente
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