Results 81 to 90 of about 10,778,046 (183)

Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons

Frontiers in Molecular Neuroscience, 2019
Secreted amyloid precursor protein-α (sAPPα) is a neuroprotective and memory-enhancing molecule, however, the mechanisms through which sAPPα promotes these effects are not well understood.
Rhys W. Livingstone, Megan K. Elder, Maya C. Barrett, Courteney M. Westlake, Katie Peppercorn, Warren P. Tate, Wickliffe C. Abraham, Joanna M. Williams   +7 more
doaj   +1 more source

A Novel Microtubule-Tau Association Enhancer and Neuroprotective Drug Candidate: Ac-SKIP

Frontiers in Cellular Neuroscience, 2019
Activity-dependent neuroprotective protein (ADNP) has been initially discovered through its eight amino acid sequence NAPVSIPQ, which shares SIP motif with SALLRSIPA – a peptide derived from activity-dependent neurotrophic factor (ADNF). Mechanistically,
Yanina Ivashko-Pachima, Illana Gozes
doaj   +1 more source

Targeted modulation of NF-κB1 in neurodegenerative diseases

Discover Neuroscience
Neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis, are characterized by progressive neuronal dysfunction and loss driven by convergent pathological mechanisms such as ...
Priyanka Banerjee, Rakesh Das, Amartya Sen, Monosiz Rahaman, Saptarshi Sanyal, Sourav Ghosh   +5 more
doaj   +1 more source

Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity

Molecular Neurodegeneration, 2011
Background The 90-kDa ribosomal S6 kinase (Rsk) family is involved in cell survival. Rsk activation is regulated by sequential phosphorylations controlled by extracellular signal-regulated kinase (ERK) 1/2 and 3-phosphoinositide-dependent protein kinase ...
Rué Laura, Anglada-Huguet Marta, Xifró Xavier, Saavedra Ana, Pérez-Navarro Esther, Alberch Jordi   +5 more
doaj   +1 more source

Postsynaptic protein kinase a reduces neuronal excitability in response to increased synaptic excitation in the Drosophila CNS [PDF]

, 2003
Previous work has identified a role for synaptic activity in the development of excitable properties of motoneurons in the Drosophila embryo. In this study the underlying mechanism that enables two such neurons, termed aCC and RP2, to respond to ...
Baines, Richard A.; id_orcid, Baines, Richard A.   +1 more
core  

ACTIVITY-DEPENDENT NEUROPROTECTIVE PROTEIN EXPRESSION IS REGIONALLY UPREGULATED BY MODERATE AEROBIC EXERCISE IN THE RAT BRAIN

European Journal of Histochemistry
Engaging in moderate aerobic exercise has been shown to significantly enhance cognitive performance and support overall brain health. Physical activity promotes adult neurogenesis and increases synaptic plasticity, particularly in brain regions involved
doaj   +1 more source

Neuroprotective effects of Peltophorum pterocarpum leaf extract against hydrogen peroxide induced oxidative stress and cytotoxicity

Clinical Phytoscience, 2017
Background Peltophorum pterocarpum is a plant from the family of Leguminosae and a tropical tree found in South East Asia region. The leaves of the plant is rich in anti-oxidant polyphenols.
Theanmalar Masilamani, Thavamanithevi Subramaniam, Norshariza Nordin, Rozita Rosli   +3 more
doaj   +1 more source

Enzyme activity and flexibility at very low hydration [PDF]

, 2005
Recent measurements have demonstrated enzyme activity at hydrations as low as 3%. This raises the question of whether hydration-induced enzyme flexibility is important for activity. Here, to address this, picosecond dynamic neutron scattering experiments
Kurkal, V., Kurkal, Vandana, Smith, Jeremy C., Tehei, M., Finney, John L., Dunn, Rachel V., Tehei, Moeava, Dunn, R.V., Daniel, R.M., Daniel, Roy M.   +9 more
core   +1 more source

A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice:implications for Rett syndrome

Frontiers in Cellular Neuroscience, 2014
Rett syndrome (RTT) is a neurodevelopmental disorder caused by loss-of-function mutations in the transcriptional modulator methyl-CpG-binding protein 2 (MECP2).
Xin eXu, Alan eKozikowski, Lucas ePozzo-Miller   +2 more
doaj   +1 more source

Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium. [PDF]

Int J Mol Sci, 2023
Maugeri G, D'Amico AG, Magrì B, Giunta S, Musumeci G, Saccone S, Federico C, Scollo D, Longo A, Avitabile T, D'Agata V.   +10 more
europepmc   +1 more source