Results 101 to 110 of about 7,722 (194)

DIPG-22. A NOVEL ROLE FOR ACVR1/ALK2 IN REGULATING CHOLESTEROL BIOSYNTHESIS PROVIDES A NEW COMBINATORIAL THERAPEUTIC APPROACH FOR PATIENTS WITH DMG

Neuro-Oncology
BACKGROUND The discovery of somatic mutations in ACVR1, which encodes the serine/threonine kinase ALK2, in 20-25% of diffuse midline glioma H3K27-altered (DMG-H3K27) patients has led to the development of numerous chemotypes of ALK2 inhibitor (ALK2i ...
Aimée du Chatinier, M. Meel, Piotr Waranecki, D. Metselaar, E. Hulleman   +4 more
semanticscholar   +1 more source

Endothelial BMP6 Drives Hemodynamic‐Dependent VSMCs Calcification in Carotid Atherosclerosis

Advanced Science, Volume 13, Issue 2, 9 January 2026.
The study demonstrates that endothelial cell (EC)‐derived BMP6 promotes the osteogenic differentiation of vascular smooth muscle cells (VSMCs) through cell‐cell interactions. Additionally, the researchers preliminarily explore the driving effect of hemodynamic factors on BMP6‐induced calcification and reveal the regulatory role of KLF4 on BMP6.
Shen Li, Shuang Cao, Peipei Li, Feng Zhang, Gangfeng Ren, Xin Wang, Jiawei Zhao, Chen Liu, Yuan Gao, Jie Xu, Yongjun Wang, Zongping Xia, Yuming Xu   +12 more
wiley   +1 more source

Activin signaling in microsatellite stable colon cancers is disrupted by a combination of genetic and epigenetic mechanisms.

PLoS ONE, 2009
BackgroundActivin receptor 2 (ACVR2) is commonly mutated in microsatellite unstable (MSI) colon cancers, leading to protein loss, signaling disruption, and larger tumors. Here, we examined activin signaling disruption in microsatellite stable (MSS) colon
Barbara Jung, Jessica Gomez, Eddy Chau, Jennifer Cabral, Jeffrey K Lee, Aimee Anselm, Przemyslaw Slowik, Deena Ream-Robinson, Karen Messer, Judith Sporn, Sung K Shin, C Richard Boland, Ajay Goel, John M Carethers   +13 more
doaj   +1 more source

Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. [PDF]

, 2017
We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases.
Adam Resnick, Alan Mackay, Alexei N. Kisljakov, Andrew J. Martin, Andrew S. Moore, André O. von Bueren, Angel Montero Carcaboso, Angela J. Waanders, Anna Burford, Baker, Barrow, Bax, Bender, Bjerke, Bouffet, Buczkowicz, Cai, Cai, Carmen de Torres, Carvalho, Castel, Ceccarelli, Chan, Chris Jones, Christopher Chandler, Cynthia Hawkins, Darach Crimmins, David Castel, David T.W. Jones, Davis, Diana Carvalho, Dmitry M. Konovalov, Dorra H’mida-Ben Brahim, Elisa Izquierdo, Fontebasso, Fontebasso, Funato, Grasso, Hamid Nikbakht, Harry J. Han, Hennika, Henry C. Mandeville, Ho-Keung Ng, Jacques Grill, Janat Fazal-Salom, Jane Cryan, Jane Pears, Jaume Mora, John Caird, Jones, Jones, Jones, João N. Stavale, Kathryn R. Taylor, Khuong-Quang, Korshunov, Korshunov, Kramm, Kun Mu, Leslie R. Bridges, Louis, Lucas T. Bidinotto, Ludmila I. Shats, Lynley Marshall, Lynn Bjerke, Mara Vinci, Marie-Anne Debily, Mariona Sunol, Maryam Fouladi, Matthew Clarke, Meera Nandhabalan, Michael Baudis, Michael Farrell, Michelle Monje, Nada Jabado, Natacha Entz-Werle, Nicolaides, Northcott, Ofelia Cruz, Ostrom, Paugh, Paugh, Paugh, Pichai Raman, Puget, Qin, Richards, Rui M. Reis, Safa Al-Sarraj, Saoussen Trabelsi, Sara Temelso, Saumya Gupta, Schiffman, Schwartzentruber, Sergey Popov, Shlien, Stefan M. Pfister, Stergios Zacharoulis, Sturm, Sturm, Sucheta Vaidya, Suzanne J. Baker, Taylor, Taylor, Temime-Smaali, Temime-Smaali, Tiberi, Valeria Molinari, Venkatesh, Welcker, Wu, Wu, Wu, Xingang Li, Yada, Yang, Zarghooni   +116 more
core   +8 more sources

T Cell Exhaustion and Dendritic Cell‐Mediated Tertiary Lymphoid Structures (TLSs) Modulation Affect Response to Neoadjuvant Chemoradiotherapy in Microsatellite Stable Rectal Cancer

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Using multi‐omics analysis, this study demonstrates that immune characteristics of the tumor microenvironment, rather than mutational profiles, are more strongly correlated with treatment response. Specifically, early exhausted T cells and tertiary lymphoid structures regulation by LAMP3⁺ dendritic cells emerge as key predictors of favorable outcomes ...
Miao Wang, Jiejun Shi, Kai Xu, Leyi Yu, Xiaomao Yin, Jiexuan Wang, Lin Zhu, Xin Yang, Jingjing Qian, Wenqiang Wang, Liangchen Zhu, Xuan Dai, Zekun Zhao, Jinran Wu, Dongsheng Li, Zhiqian Hu, Qi Huang, Xinxing Li   +17 more
wiley   +1 more source

cIMPACT‐NOW update 11: Proposal on adaptation of diagnostic criteria for IDH‐ and H3‐wildtype diffuse high‐grade gliomas and for posterior fossa ependymal tumors

Brain Pathology, Volume 36, Issue 1, January 2026.
Abstract The Consortium to Inform Molecular and Practical Approaches to Central Nervous System Tumor Taxonomy (cIMPACT‐NOW) updates provide guidelines for the diagnosis of central nervous system (CNS) tumors and suggestions for future World Health Organization (WHO) classification.
Pieter Wesseling, David Capper, Guido Reifenberger, Chitra Sarkar, Cynthia Hawkins, Arie Perry, Bette Kleinschmidt‐DeMasters, Takashi Komori, Werner Paulus, Vani Santosh, Martin van den Bent, Michael Weller, Stefan M. Pfister, Uri Tabori, Dominique Figarella‐Branger, Brent A. Orr, David N. Louis   +16 more
wiley   +1 more source

Intersection of brain development and paediatric diffuse midline gliomas: potential role of microenvironment in tumour growth [PDF]

, 2018
Diffuse intrinsic pontine glioma (DIPG) is a devastating and incurable paediatric brain tumour with a median overall survival of 9 months. Until recently, DIPGs were treated similarly to adult gliomas, but due to the advancement in molecular and imaging ...
Fillmore, Helen, Loveson, Katie
core   +1 more source

Efficacy of Momelotinib in Myelofibrosis Patients: Results From a Multicenter Study

European Journal of Haematology, Volume 116, Issue 1, Page 23-30, January 2026.
ABSTRACT Momelotinib, a novel JAK1/2 inhibitor with inhibitory activities on activin A receptor type I, has shown breakthrough clinical efficacy in patients with myelofibrosis (MF) and anemia, a disease‐related manifestation of challenging management. In this retrospective real‐life multicenter Italian study, we investigated the safety and efficacy of ...
Maria Carmen Martorelli, Novella Pugliese, Maria Di Perna, Danilo De Novellis, Assunta Lombardi, Laura De Fazio, Giuseppina Loglisci, Ilaria Peluso, Matteo Molica, Carolina Copia, Alessandra Ricco, Antonella Bruzzese, Francesco Mendicino, Vincenza De Fazio, Teresa Maria Santeramo, Rosario Bianco, Giuseppe Monaco, Raffaele Fontana, Roberto Guariglia, Bianca Serio, Serena Luponio, Anna Maria Della Corte, Antonella Malandrini, Valentina Giudice, Ferdinando Frigeri, Giuseppe Tarantini, Attilio Guarini, Massimo Gentile, Pellegrino Musto, Mario Annunziata, Nicola Di Renzo, Marco Rossi, Catello Califano, Fabrizio Pane, Carmine Selleri   +34 more
wiley   +1 more source

Mutation Detection in Activin A Receptor, Type I (ACVR1) Gene in Fibrodysplasia Ossificans Progressiva in An Iranian Family [PDF]

Cell Journal, 2014
Fibrodysplasia Ossificans Progressiva (FOP, MIM 135100) is a rare genetic disease that is often inherited sporadically in an autosomal dominant pattern. The disease manifests in early life with malformed great toes and, its episodic and progressive bone ...
Ziba Morovvati, Saeid Morovvati, Gholamhossein Alishiri, Seyed Hossein Moosavi, Reza Ranjbar, Yaser Bolouki Moghaddam   +5 more
doaj  

Current state of therapeutic development for rare cancers in Japan, and proposals for improvement [PDF]

, 2018
This article discusses current obstacles to the rapid development of safe and effective treatments for rare cancers, and considers measures required to overcome these challenges.
Ando Masashi, Goto Toshio, Heike Toshio, Kawai Akira, Kimura Shinya, Matsui Shigeyuki, Matsumoto Seiichi, Mizutani Shuki, Monden Morito, Nagata Kyosuke, Narukawa Mamoru, Nishikawa Akiyoshi, Shibata Taro, Shibata Tatsuhiro, Tani Kenzaburo, Toguchida Junya, Ueda Ryuzo, 永田 恭介   +17 more
core   +2 more sources