Results 51 to 60 of about 7,722 (194)

Survival rates and prognostic predictors of high grade brain stem gliomas in childhood : a systematic review and meta-analysis [PDF]

, 2017
Diagnosis of a pediatric high grade brain stem glioma is devastating with dismal outcomes. This systematic review and meta-analysis was undertaken to determine the survival rates and assess potential prognostic factors including selected interventions ...
Hassan, Hadeel, Phillips, Robert S, Picton, Susan V, Pinches, Anne   +3 more
core   +1 more source

Functional comparison of human ACVR1 and zebrafish Acvr1l FOP‐associated variants in embryonic zebrafish

Developmental Dynamics, 2023
Fibrodysplasia ossificans progressiva (FOP), a rare disease characterized by progressive heterotopic ossification of muscle and connective tissues, is caused by autosomal dominant activating mutations in the type I receptor, ACVR1/ALK2. The classic human
R. L. Lalonde, H. Nicolas, Rowan S Cutler, Irene Pantekidis, Weibo Zhang, P. Yelick   +5 more
semanticscholar   +1 more source

Cross-talk among AFAP1-AS1, ACVR1 and microRNA-384 regulates the stemness of pancreatic cancer cells and tumorigenicity in nude mice

Journal of Experimental & Clinical Cancer Research, 2019
Background Pancreatic cancer (PC) represents one of the most aggressive forms of cancer. The role of long non-coding RNAs (lncRNAs) has been highlighted in various malignancies including PC.
Xu-Bo Wu, Xia Feng, Qi-Meng Chang, Cheng-Wu Zhang, Zhi-Fei Wang, Jie Liu, Zhi-Qiu Hu, Jia-Zhe Liu, Wei-Ding Wu, Zi-Ping Zhang, Xi-Qiang Liu   +10 more
doaj   +1 more source

Twists in the fibrodysplasia ossificans progressiva story challenge and expand our understanding of BMP biology

The Journal of Clinical Investigation, 2022
Fibrodysplasia ossificans progressiva (FOP) is an ultrarare, debilitating disease in which heterotopic bone is formed in certain soft tissues. A gain-of-function variant in the cytoplasmic domain of the activin A receptor type I (ACVR1) exists in all ...
Michael T. Collins
doaj   +1 more source

Myositis ossificans circumscripta of the buccinator muscle: first report of a rare complication of mandibular third molar extraction. [PDF]

, 2008
Myositis ossificans is a self-limiting ossifying process that most often develops following mechanical trauma to skeletal musculature. It chiefly affects the skeletal muscles of extremities of young athletically active adult males. Myositis ossificans is
Abramovitch, Kenneth, Bouquot, Jerry, Thurber, David, Vigneswaran, Nadarajah, Wiggins, Raymond L   +4 more
core   +1 more source

S249: SELECTIVE JAK2/IRAK1/ACVR1 INHIBITOR PACRITINIB BEFORE REDUCED-INTENSITY CONDITIONING ALLOGENEIC STEM CELL TRANSPLANTATION IN MYELOFIBROSIS: FINAL ANALYSIS OF THE PHASE II HOVON-134 TRIAL

HemaSphere, 2023
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Ruben Van Dijck, Ron VAN DER Holt, E. Meijer, T. Devos, M. Hazenberg, M. V. D. van der Poel, D. Breems, L. Deleu, N. Schaap, Peter André Willem Te Boekhorst   +9 more
semanticscholar   +1 more source

An mTOR Signaling Modulator Suppressed Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva

Stem Cell Reports, 2018
Summary: Fibrodysplasia ossificans progressiva (FOP) is a rare and intractable disorder characterized by extraskeletal bone formation through endochondral ossification.
Kyosuke Hino, Chengzhu Zhao, Kazuhiko Horigome, Megumi Nishio, Yasue Okanishi, Sanae Nagata, Shingo Komura, Yasuhiro Yamada, Junya Toguchida, Akira Ohta, Makoto Ikeya   +10 more
doaj   +1 more source

ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans

Pain, 2022
Supplemental Digital Content is Available in the Text. An ACVR1 activating mutation causes heat and mechanical pain hypersensitivity and induces sensory neuron hyperexcitability in humans.
Xiaobing Yu, A. Ton, Zejun Niu, Blanca M. Morales, Jiadong Chen, J. Braz, Michael H. Lai, Emilie Barruet, Hongju Liu, K. Cheung, S. Ali, Tea Chan, K. Bigay, Jennifer Ho, Ina Nikolli, S. Hansberry, K. Wentworth, A. Kriegstein, A. Basbaum, E. Hsiao   +19 more
semanticscholar   +1 more source

How Activin A Became a Therapeutic Target in Fibrodysplasia Ossificans Progressiva

Biomolecules
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by episodic yet cumulative heterotopic ossification (HO) of skeletal muscles, tendons, ligaments, and fascia. FOP arises from missense mutations in Activin Receptor type
Dushyanth Srinivasan, Martin Arostegui, Erich J. Goebel, Kaitlin N. Hart, Senem Aykul, John B. Lees-Shepard, Vincent Idone, Sarah J. Hatsell, Aris N. Economides   +8 more
doaj   +1 more source

Recent Topics in Fibrodysplasia Ossificans Progressiva [PDF]

Endocrinology and Metabolism, 2018
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease that is characterized by the formation of heterotopic bone tissues in soft tissues, such as skeletal muscle, ligament, and tendon.
Takenobu Katagiri, Sho Tsukamoto, Yutaka Nakachi, Mai Kuratani   +3 more
doaj   +1 more source