Results 11 to 20 of about 54,274 (285)

Neonates with acute liver failure have higher overall mortality but similar posttransplant outcomes as older infants

Liver Transplantation, EarlyView., 2022
Abstract Neonatal acute liver failure (ALF) carries a high mortality rate; however, little data exist on its peritransplant hospital course. This project aimed to identify factors associated with outcomes in neonates with ALF using large multicenter databases.
Swati Antala, Bridget Whitehead, Justin Godown, Matt Hall, Anna Banc‐Husu, Estella M. Alonso, Sarah A. Taylor   +6 more
wiley   +1 more source

Shedding a Light on Acyclovir Pharmacodynamics: A Retrospective Analysis on Pharmacokinetic/Pharmacodynamic Modelling of Acyclovir for the Treatment of Varicella Zoster Virus Infection in Immunocompromised Patients: A Pilot Study

Pharmaceutics, 2022
Background: Acyclovir and valacyclovir are used for the treatment and prophylaxis of infections with herpes simplex virus (HSV) and varicella zoster virus (VZV). The aim of this study is to provide insight into the pharmacodynamics (PD) of (val)acyclovir.
Geeske F. Grit, Anne-Grete Märtson, Marjolein Knoester, Marlous L. Toren-Wielema, Daan J. Touw   +4 more
doaj   +1 more source

A Flavonoid-Rich Extract of Scoparia dulcis L. Exhibits Antiviral Activity against Herpes Virus Type 1. [PDF]

Chem Biodivers
ABSTRACT This study investigated the phytochemical profile, cytotoxicity, and anti‐herpetic activity of the hydroethanolic extract from Scoparia dulcis L. aerial parts. Mass spectrometry revealed the presence of 15 compounds. The extract showed low cytotoxicity in Vero cells, maintaining over 80% viability at concentrations up to 250 µg/mL.
Jales FLML, Siqueira EMDS, Dantas-Medeiros R, de Araújo ERD, Alves JSF, Rocha HAO, Lopes NP, Ferreira LS, Tavares EA, Zucolotto SM.   +9 more
europepmc   +2 more sources

Central Composite Design for Formulation and Optimization of Solid Lipid Nanoparticles to Enhance Oral Bioavailability of Acyclovir

Molecules, 2021
Treatment of herpes simplex infection requires high and frequent doses of oral acyclovir to attain its maximum therapeutic effect. The current therapeutic regimen of acyclovir is known to cause unwarranted dose-related adverse effects, including acute ...
Haniza Hassan, Siti Khadijah Adam, Ekram Alias, Meor Mohd Redzuan Meor Mohd Affandi, Ahmad Fuad Shamsuddin, Rusliza Basir   +5 more
doaj   +1 more source

Herpes simplex keratitis: Challenges in diagnosis and clinical management [PDF]

, 2017
Herpes simplex virus is responsible for numerous ocular diseases, the most common of which is herpetic stromal keratitis. This is a recurrent infection of the cornea that typically begins with a subclinical infection of the cornea that establishes a ...
Azher, Tayaba N, Huang, Andrew JW, Stuart, Patrick M, Tajfirouz, Deena, Yin, Xiao-Tang   +4 more
core   +3 more sources

Vitreous pharmacokinetics and electroretinographic findings after intravitreal injection of acyclovir in rabbits

Clinics, 2012
OBJECTIVES: Acute retinal necrosis is a rapidly progressive and devastating viral retinitis caused by the herpesvirus family. Systemic acyclovir is the treatment of choice; however, the progression of retinal lesions ceases approximately 2 days after ...
Francisco Max Damico, Mariana Ramos Scolari, Gabriela Lourençon Ioshimoto, Beatriz Sayuri Takahashi, Armando da Silva Cunha Jr., Sílvia Ligório Fialho, Daniela Maria Bonci, Fabio Gasparin, Dora Fix Ventura   +8 more
doaj   +1 more source

Varicella-Zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line [PDF]

, 2013
Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV). We undertook a heterologous infection in vitro study to determine whether PHN-associated VZV isolates ...
A Vafai, BM Bradley, C Bourdon-Wouters, C Han, D Quan, DH Gilden, DW Wareham, Edward G. Rowan, EM Garry, Esther Grinfeld, Fiona Scott, FS Hasnie, FT Scott, G Ashrafi, G. H. Ashrafi, J Fogh, J Lai, JD Markman, JN Wood, Joseph Charles Glorioso, Judith Breuer, MA Hamza, MH Meisler, MJ Craner, MJ Quinlivan, ML Szpara, N Storey, Paul Montague, Peter G. E. Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, PR Kinchington, R Dabby, R Mahalingam, RG Dalziel, RL Finnen, S Schünemann, SG Waxman, SJ Medhurst, SM Fleetwood-Walker, TR Cummins, W Peng, WA Catterall, X Zhou   +44 more
core   +3 more sources

Acyclovir Has Low but Detectable Influence on HLA-B*57:01 Specificity without Inducing Hypersensitivity. [PDF]

PLoS ONE, 2015
Immune mediated adverse drug reactions (IM-ADRs) remain a significant source of patient morbidity that have more recently been shown to be associated with specific class I and/or II human leukocyte antigen (HLA) alleles. Abacavir-induced hypersensitivity
Imir G Metushi, Amanda Wriston, Priyanka Banerjee, Bjoern Oliver Gohlke, A Michelle English, Andrew Lucas, Carrie Moore, John Sidney, Soren Buus, David A Ostrov, Simon Mallal, Elizabeth Phillips, Jeffrey Shabanowitz, Donald F Hunt, Robert Preissner, Bjoern Peters   +15 more
doaj   +1 more source

In vitro susceptibility of six isolates of equine herpesvirus 1 to acyclovir, ganciclovir, cidofovir, adefovir, PMEDAP and foscarnet [PDF]

, 2007
International ...
Croubels, Siska, De Backer, Patrick, Garré, Barbara, Nauwynck, Hans, NEYTS, J, NUGENT, J, VAN DER MEULEN, K   +6 more
core   +3 more sources

A prospective randomized trial comparing sequential ganciclovir-high dose acyclovir to high dose acyclovir for prevention of cytomegalovirus disease in adult liver transplant recipients [PDF]

, 1994
Cytomegalovirus disease is an important cause of morbidity following liver transplantation. To date there has not been an effective prophylaxis for CMV disease after liver transplantation.
Estores, D, Felser, I, Fung, J, Ho, M, Irish, W, Kisor, D, Kusne, S, Linden, P, Martin, M, Mañez, R, Ondick, L, Ptachcinski, R, Rinaldo, C, Simmons, R, Starzl, T, Stieber, A, Torre-Cisneros, J   +16 more
core   +1 more source