Results 21 to 30 of about 31,404 (216)

Acyclovir-Loaded Chitosan Nanospheres from Nano-Emulsion Templating for the Topical Treatment of Herpesviruses Infections

Pharmaceutics, 2018
Acyclovir is not a good candidate for passive permeation since its polarity and solubility limit is partitioning into the stratum corneum. This work aims to develop a new topical formulation for the acyclovir delivery.
Manuela Donalisio, Federica Leone, Andrea Civra, Rita Spagnolo, Ozgen Ozer, David Lembo, Roberta Cavalli   +6 more
doaj   +1 more source

A Randomized, Double-blind, Placebo-Controlled Study of Efficacy of Oral Acyclovir in the Treatment of Pityriasis Rosea [PDF]

Journal of Clinical and Diagnostic Research, 2014
Background: Pityriasis rosea is an acute self-limiting skin disorder of unknown aetiology. Recently human herpes virus 6 and 7 has been hypothesized to be the cause of pityriasis rosea. Objective: To determine the efficacy of acyclovir, an anti-viral
Satyaki Ganguly
doaj   +1 more source

Pseudoboehmite as a drug delivery system for acyclovir

Scientific Reports, 2021
Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses and it is indicated for the treatment and management of recurrent cold sores on the lips and face, genital ...
Renato Meneghetti Peres, Jéssica Maiara Leme Sousa, Mariana Oliva de Oliveira, Maura Vincenza Rossi, Rene Ramos de Oliveira, Nelson Batista de Lima, Ayrton Bernussi, Juliusz Warzywoda, Bruno Sarmento, Antonio Hortencio Munhoz   +9 more
doaj   +1 more source

Synthesis, Characterization and Safety Evaluation of Sericin-Based Hydrogels for Controlled Delivery of Acyclovir

Pharmaceuticals, 2021
Conventional formulations of antiviral drug acyclovir have various limitations such as low bioavailability. The current study was aimed at developing polymeric matrices for the controlled delivery of acyclovir using sericin as polymer and acrylic acid ...
Moawia M. Al-Tabakha, Shujaat Ali Khan, Akram Ashames, Hamid Ullah, Kaleem Ullah, Ghulam Murtaza, Nageeb Hassan   +6 more
doaj   +1 more source

Acyclovir inhibition of IDO to decrease Tregs as a glioblastoma treatment adjunct

Journal of Neuroinflammation, 2010
Regulatory T cells, Tregs, are a subset of lymphocytes that have immunosuppressive attributes. They are elevated in blood of glioblastoma patients and within this tumor's tissue itself. Indoleamine 2,3-dioxygenase, IDO, converts tryptophan to kynurenine.
Söderlund Johan, Erhardt Sophie, Kast Richard E   +2 more
doaj   +1 more source

Pharmacokinetic and Efficacy Study of Acyclovir Against Cyprinid Herpesvirus 3 in Cyprinus carpio

Frontiers in Veterinary Science, 2020
Cyprinid Herpesvirus 3 (CyHV-3), more commonly known as Koi Herpesvirus (KHV), is a re-emergent virus causing acute systemic infection with high mortality rates in koi fish (Cyprinus carpio).
Eva Marie Quijano Cardé, Zeinab Yazdi, Susan Yun, Ruixue Hu, Heather Knych, Denise M. Imai, Esteban Soto   +6 more
doaj   +1 more source

Incidence, patterns, risk factors and clinical outcomes of intravenous acyclovir induced nephrotoxicity

Saudi Pharmaceutical Journal, 2022
Objectives: Acyclovir is approved to treat herpes simplex virus (HSV) type 1, type 2 and varicella-zoster virus. It is mainly eliminated via the kidneys, for which drug crystals accumulation might lead to nephrotoxicity. This study aimed to determine the
Abdullah M. Al-Alawi, Juhaina Salim Al-Maqbali, Maria Al-Adawi, Anan Al-Jabri, Henrik Falhammar   +4 more
doaj  

Therapeutic effects of acyclovir and acyclovir-clobetasol nanofibers vs. cream formulation for recurrent herpes labialis

BMC Oral Health
Objectives This study aims to compare the therapeutic effects of acyclovir nanofiber and acyclovir-clobetasol nanofiber formulations with their non-nano formulations (cream formulation) on recurrent labial herpes.
Shahla Mirzaei, Zahra Golestan Nejad, Faezeh Khozaimeh, Solmaz Mohammadi, Alireza Loqmani   +4 more
doaj   +1 more source

Hexokinase‐2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming

Advanced Science, EarlyView.
Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang, Yining Sun, Xintong Yu, Ruoqi Wang, Yuting Zhang, Jinjie Yu, Shuang Xie, Yujia Cai, Yuhong Luo, Wei Chen   +9 more
wiley   +1 more source

Commensal Viruses Promote Intestinal Stem Cell Regeneration Following Radiation Damage by Inhibiting Hyperactivation of RIG‐I and Notch Signals

Advanced Science, EarlyView.
Ionizing radiation disrupts gut virome and bacteriome. Gut commensal viruses protect against intestinal damage and promote stem cell regeneration by inhibiting hyperactivation of RIG‐I and Notch signaling in stem cells. Fecal virome transplantation (FVT) from healthy donors can serve as a potential therapeutic intervention by enriching phages targeting
Xiaotong Zhao, Yu Cai, Yujia Hou, Yanjin Wu, Tingting Wei, Lili Li, Zhaojun Duan, Xinran Lu, Jiahui Meng, Haitao Zhou, Qin Wang, Jinhan Wang, Chang Xu, Liqing Du, Saijun Fan, Feng Wang, Qiang Liu, Yang Liu   +17 more
wiley   +1 more source