Results 51 to 60 of about 30,581 (218)

Challenges for the improvement of valganciclovir prophylaxis in solid organ transplantation and the possible role of therapeutic drug monitoring in adults

British Journal of Clinical Pharmacology, EarlyView.
Cytomegalovirus (CMV) infection frequently occurs after solid organ transplantation and is associated with an increased morbidity and mortality. Fortunately, the development of valganciclovir prophylaxis has lowered the incidence of CMV infection and its complications in immunosuppressed solid organ transplant recipients.
Lukas K. van Vugt, Dennis A. Hesselink, Brenda C. M. de Winter   +2 more
wiley   +1 more source

When, which and how to switch: Navigating JAK inhibitors in myelofibrosis

British Journal of Haematology, EarlyView.
Navigating choice of JAK inhibitor (JAKi) therapy for patients with myelofibrosis who are JAKi‐naïve and for those who have previously been treated with a JAKi.
Jennifer O'Sullivan, Imran Omerdeen, Bethan Psaila   +2 more
wiley   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Antiviral-Resistant Fulminant Herpes Hepatitis in Pregnancy

American Journal of Perinatology Reports, 2013
Fulminant herpes hepatitis with disseminated extrahepatic involvement in pregnancy is rare and carries a high mortality risk. Although acyclovir remains standard first-line therapy, effective management of acyclovir-resistant disseminated herpes simplex ...
Christina A. Herrera, Kacey Y. Eichelberger, Nancy C. Chescheir   +2 more
doaj   +1 more source

Acyclovir and postherpetic neuralgia

Biomedicine & Pharmacotherapy, 1990
Studies have demonstrated the benefit of acyclovir, given intravenously or orally, on the acute illness in herpes zoster (HZ). Whether or not such treatment influences the subsequent development of postherpetic neuralgia (PHN) has been the subject of recent controversy.
Klenerman, P, Luzzi, G
openaire   +4 more sources

Clinical characteristics and treatment of varicella zoster virus central nervous system infection in an Australian tertiary hospital

Internal Medicine Journal, EarlyView.
Abstract Background and Aim Varicella zoster virus (VZV) is a neurotropic herpesvirus. With improved access to molecular diagnostics, there is increasing recognition of VZV with central nervous system involvement. This study aimed to describe the demographic, clinical and treatment characteristics of patients admitted to an Australian tertiary hospital
Connie Lam, Eve Chen, Arthur Thevathasan, Terry Yan, Michael Moso, Joe Sasadeusz, Stephen Muhi   +6 more
wiley   +1 more source

Low-Dose Acyclovir Prophylaxis for Varicella zoster Reactivation in Autologous Hematopoietic Cell Transplantation Recipients

Clinical Hematology International, 2019
Varicella zoster virus (VZV) reactivation after autologous hematopoietic cell transplantation (auto-HCT) may be observed in a quarter of patients.
Naomi Fei, Nilay Shah, Aaron Cumpston, Sijin Wen, Kelly G. Ross, Michael Craig, Abraham S. Kanate   +6 more
doaj   +1 more source

Darier disease: Current insights and challenges in pathogenesis and management

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Darier disease (DD) is characterized by the following: Disrupted Ca2+ gradients, impaired desmosomes, impaired keratinocyte differentiation, type 17 inflammation, DC and LC ↓, Th17 cells ↑. DD treatment: First line: keratinocyte focused and/or anti‐inflammatory. Second line: experimental approaches like specific targeting of the inflammatory infiltrate.
Monika Ettinger, Susanne Kimeswenger, Isabella Deli, Judith Traxler, Sabine Altrichter, Petar Noack, Jakob D. Wikstrom, Emmanuella Guenova, Wolfram Hoetzenecker   +8 more
wiley   +1 more source

The incidence, risk factors, and clinical outcomes of acute kidney injury (staged using the RIFLE classification) associated with intravenous acyclovir administration

Renal Failure, 2018
Intravenous (IV) acyclovir is commonly administered medication for viral infection but is well known for its nephrotoxicity. However, there was no study for incidence, risk factors, and clinical outcomes of acute kidney injury (AKI) associated with IV ...
Eun Ju Lee, Ha Nee Jang, Hyun Seop Cho, Eunjin Bae, Tae Won Lee, Se-Ho Chang, Dong Jun Park   +6 more
doaj   +1 more source

Association of Posttransplant Circulating 25‐Hydroxyvitamin D and Late‐Onset Infections Among Kidney Transplant Recipients: The Wisconsin Allograft Recipient Database (WisARD)

Transplant Infectious Disease, EarlyView.
Lower posttransplant circulating 25(OH)D level is significantly associated with a higher incidence of late‐onset infection among kidney transplant recipients, especially urinary tract infections in male recipients. ABSTRACT Introduction Late‐onset infection occurring more than 6 months after transplantation is a major threat to the long‐term survival ...
Zhongyu Yuan, Michal L. Melamed, Sandesh Parajuli, Didier Mandelbrot, Brad C. Astor   +4 more
wiley   +1 more source