Experimental Data Confirm Carrier-Cascade Model for Solid-State Conductance across Proteins [PDF]
arXivThe finding that electronic conductance across ultra-thin protein films between metallic electrodes remains nearly constant from room temperature to just a few degrees Kelvin has posed a challenge. We show that a model based on a generalized Landauer formula explains the nearly constant conductance and predicts an Arrhenius-like dependence for low ...
arxiv
Regulation of Acyl Carrier Protein Messenger RNA Levels during Seed and Leaf Development [PDF]
, 1988 David J. Hannapel, John B. Ohlrogge
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Self‐Assembly of Linear, Natural Antimicrobial Peptides: An Evolutionary Perspective
ChemPlusChem, Volume 87, Issue 12, December 2022., 2022 Antimicrobial peptides are an ancient defence against a wide range of microbes. Some can self‐assemble into oligomers and amyloid. Similarities with neurodegenerative diseases support a hypothesis that some diseases are due to aberrant activity of a protective neuropeptide.
Verity Baltutis +2 more
wiley +1 more source
Angewandte Chemie International Edition, EarlyView.Generating functionalized ubiquitin building blocks via expression in E. coli paves the way to different di‐, tri‐, and tetra‐ubiquitin chains. Light‐induced thiol‐ene click reactions, combined with a masking and protection strategy, are harnessed to establish controlled ubiquitin chain assembly and to allow the semisynthesis of site‐selectively ...
Moritz Urschbach +6 more
wiley +1 more source
Impact of Lipid Structural Variations on Bilayer Properties: A Coarse-Grained Molecular Dynamics Study [PDF]
arXivThe supramolecular assembly of lipids into bilayer membranes is essential for cellular structure and function. However, the impact of lipid structural variations such as acyl chain length, degree of unsaturation, and headgroup type on bilayer properties remains incompletely understood.
arxiv
Molecular cloning and sequencing of a cDNA encoding the acyl carrier protein and its flanking domains in the mammalian fatty acid synthetase [PDF]
, 1987 Andrzej Witkowski +3 more
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ChemPhotoChem, Volume 6, Issue 12, December 2022., 2022 Photoswitchable cross‐linkers have the ability to connect two residues on a biomolecule, thereby causing large changes in the structure and function of the target upon irradiation. The design, synthesis and purification of cross‐linkers with large end‐to‐end distances remains challenging, especially for applications in chemical biology.
Jana Volarić +3 more
wiley +1 more source
Structure-Based Design and Pharmacophore-Based Virtual Screening of Combinatorial Library of Triclosan Analogues Active against Enoyl-Acyl Carrier Protein Reductase of Plasmodium falciparum with Favourable ADME Profiles. [PDF]
Int J Mol Sci, 2023 Bieri C +7 more
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Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023 Saturated fatty acids induce insulin resistance in neurons. Neuronal metabolism of palmitic acid alters mitochondrial function. Abstract Introduction Saturated fatty acids (FAs) are the main component of high‐fat diets (HFDs), and high consumption has been associated with the development of insulin resistance, endoplasmic reticulum stress and ...
Karina Sánchez‐Alegría +1 more
wiley +1 more source
Angewandte Chemie International Edition, Accepted Article.Polyether polyketides are a structurally diverse group of natural products known for their antimicrobial and antiproliferative activities. Lasalocid A is a canonical natural polyether produced by the soil bacterium Streptomyces lasalocidi. In lasalocid A biosynthesis, a polyene polyketide intermediate is converted to a bisepoxide by the flavin ...
Chu-Young Kim +12 more
wiley +1 more source