Determination of the Protein-Protein Interactions within Acyl Carrier Protein (MmcB)-Dependent Modifications in the Biosynthesis of Mitomycin [PDF]
Molecules, 2021 Mitomycin has a unique chemical structure and contains densely assembled functionalities with extraordinary antitumor activity. The previously proposed mitomycin C biosynthetic pathway has caused great attention to decipher the enzymatic mechanisms for ...
Dongjin Leng +7 more
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SCO6564, a novel 3-ketoacyl acyl carrier protein synthase III, contributes in fatty acid synthesis in Streptomyces coelicolor. [PDF]
PLoS ONEThe genus Streptomyces comprises gram-positive bacteria that produce large numbers of secondary metabolites, which have promising commercial applications and deserve extensive study.
Jian-Rong Ma +6 more
doaj +2 more sources
Decoding allosteric regulation by the acyl carrier protein. [PDF]
Proc Natl Acad Sci U S A, 2021 SignificanceAcyl carrier proteins (ACPs) are involved in primary and secondary metabolic pathways, including the ubiquitous fatty acid biosynthesis, required for all domains of life. This single protein must deliver pathway intermediates to the appropriate enzyme, distinguishing between a myriad of possible intermediate-enzyme combinations.
Sztain T +8 more
europepmc +7 more sources
Stearoyl-Acyl Carrier Protein and Unusual Acyl-Acyl Carrier Protein Desaturase Activities Are Differentially Influenced by Ferredoxin [PDF]
Plant Physiology, 2000 Abstract Acyl-acyl carrier protein (ACP) desaturases function to position a single double bond into an acyl-ACP substrate and are best represented by the ubiquitous Δ9 18:0-ACP desaturase. Several variant acyl-ACP desaturases have also been identified from species that produce unusual monoenoic fatty acids.
David J. Schultz +2 more
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Mycobacterial acyl carrier protein suppresses TFEB activation and upregulates miR-155 to inhibit host defense [PDF]
Frontiers in Immunology, 2022 Mycobacterial acyl carrier protein (AcpM; Rv2244), a key protein involved in Mycobacterium tuberculosis (Mtb) mycolic acid production, has been shown to suppress host cell death during mycobacterial infection.
Seungwha Paik +21 more
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Interfacial Enzymes Enable Gram-Positive Microbes to Eat Fatty Acids
Membranes, 2023 Exogenous fatty acid (eFA) activation and utilization play key roles in bacterial physiology and confer growth advantages by bypassing the need to make fatty acids for lipid synthesis.
Christopher D. Radka
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Frontiers in Microbiology, 2022 The fatty acid synthase type II (FAS-II) multienzyme system is the main target of drugs to inhibit mycolic acid synthesis in mycobacterium. Meromycolate extension acyl carrier protein (AcpM) serves as the carrier of fatty acyl chain shuttling among the ...
Mengmiao Li +7 more
doaj +1 more source
Involvement of Arabidopsis Acyl Carrier Protein 1 in PAMP-Triggered Immunity
Molecular Plant-Microbe Interactions, 2022 Plant fatty acids (FAs) and lipids are essential in storing energy and act as structural components for cell membranes and signaling molecules for plant growth and stress responses.
Zhenzhen Zhao +6 more
doaj +1 more source
Acyl Carrier Protein in Mycoplasmas [PDF]
Journal of Bacteriology, 1973 Acyl carrier protein (ACP) activity was determined by the malonyl-coenzyme A–CO 2 exchange reaction. It was highest in Acholeplasma laidlawii , lower in A. granularum , and lowest in A. axanthum . The sterol-requiring Mycoplasma
Shlomo Rottem +2 more
openaire +3 more sources
Acylation of the Type 3 Secretion System Translocon Using a Dedicated Acyl Carrier Protein. [PDF]
PLoS Genetics, 2017 Bacterial pathogens often deliver effectors into host cells using type 3 secretion systems (T3SS), the extremity of which forms a translocon that perforates the host plasma membrane.
Julie P Viala +10 more
doaj +1 more source