Results 31 to 40 of about 46,162 (199)

Versatility of Acyl-Acyl Carrier Protein Synthetases

Chemistry & Biology, 2014
The acyl carrier protein (ACP) requires posttranslational modification with a 4'-phosphopantetheine arm for activity, and this thiol-terminated modification carries cargo between enzymes in ACP-dependent metabolic pathways. We show that acyl-ACP synthetases (AasSs) from different organisms are able to load even, odd, and unnatural fatty acids onto E ...
Kara Finzel, Joris Beld, Michael D. Burkart   +2 more
openaire   +3 more sources

The Nodulation Protein NodG Shows the Enzymatic Activity of an 3-Oxoacyl-Acyl Carrier Protein Reductase

Molecular Plant-Microbe Interactions, 2001
The acyl carrier protein NodF is required for the synthesis of unusual polyunsaturated fatty acids that confer specificity to lipochitin oligosaccharide nodulation (Nod) factors of Rhizobium leguminosarum. In this study, homogeneous NodF protein was used
Isabel M. López-Lara, Otto Geiger
doaj   +1 more source

Enhanced Rishirilide Biosynthesis by a Rare In-Cluster Phosphopantetheinyl Transferase in Streptomyces xanthophaeus

Microbiology Spectrum, 2022
Phosphopantetheinyl transferases (PPTases) play important roles in activating apo-acyl carrier proteins (apo-ACPs) and apo-peptidyl carrier proteins (apo-PCPs) in both primary and secondary metabolism. PPTases catalyze the posttranslational modifications
Songya Zhang, Shuai Fan, Jing Zhu, Liying Zhou, Xiaohui Yan, Zhaoyong Yang, Tong Si, Tao Liu   +7 more
doaj   +1 more source

The Acyl‐Carrier Protein of Citrate Lyase [PDF]

European Journal of Biochemistry, 1973
When [14C]acetyl citrate lyase was dissociated in sodium dodecylsulfate and the products were separated by gel electrophoresis, all of the radioactive label appeared in a small protein. This had a molecular weight of about 10000 and contained phosphopantetheine.
Peter Dimroth, Hermann Eggerer, Gundel Walther, Wolfgang Dittmar   +3 more
openaire   +3 more sources

ACBP and cholesterol differentially alter fatty acyl CoA utilization by microsomal ACAT

Journal of Lipid Research, 2003
Microsomal acyl CoA:cholesterol acyltransferase (AC57) is stimulated in vitro and/or in intact cells by proteins that bind and transfer both substrates, cholesterol, and fatty acyl CoA.
Hsu Chao, Minglong Zhou, Avery McIntosh, Friedhelm Schroeder, Ann B. Kier   +4 more
doaj   +1 more source

Improving hydrocarbon production by engineering cyanobacterial acyl-(acyl carrier protein) reductase

Biotechnology for Biofuels, 2019
Background Acyl-(acyl carrier protein (ACP)) reductase (AAR) is a key enzyme for hydrocarbon biosynthesis in cyanobacteria, reducing fatty acyl-ACPs to aldehydes, which are then converted into hydrocarbons by aldehyde-deformylating oxygenase (ADO ...
Hisashi Kudo, Yuuki Hayashi, Munehito Arai   +2 more
doaj   +1 more source

Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase

Nature Communications, 2020
Acyl-acyl carrier protein reductase (AAR) and aldehyde deformylating oxygenase (ADO) are the two enzymes in a cyanobacterial alkane biosynthesis pathway that is of interest for biofuel production.
Yu Gao, Hongmei Zhang, Minrui Fan, Chenjun Jia, Lifang Shi, Xiaowei Pan, Peng Cao, Xuelin Zhao, Wenrui Chang, Mei Li   +9 more
doaj   +1 more source

Expression of a recombinant, 4'-Phosphopantetheinylated, active M. tuberculosis fatty acid synthase I in E. coli. [PDF]

PLoS ONE, 2018
BACKGROUND:Fatty acid synthase 1 (FAS I) from Mycobacterium tuberculosis (Mtb) is an essential protein and a promising drug target. FAS I is a multi-functional, multi-domain protein that is organized as a large (1.9 MDa) homohexameric complex.
Szilvia Baron, Yoav Peleg, Jacob Grunwald, David Morgenstern, Nadav Elad, Moshe Peretz, Shira Albeck, Yishai Levin, John T Welch, Kim A DeWeerd, Alon Schwarz, Yigal Burstein, Ron Diskin, Zippora Shakked, Oren Zimhony   +14 more
doaj   +1 more source

Morphing Natural Product Platensimycin via Heck, Sonogashira, and One-Pot Sonogashira/Cycloaddition Reactions to Produce Antibiotics with In Vivo Activity

Antibiotics, 2022
Type II fatty acid synthases are promising drug targets against major bacterial pathogens. Platensimycin (PTM) is a potent inhibitor against β-ketoacyl-[acyl carrier protein] synthase II (FabF) and β-ketoacyl-[acyl carrier protein] synthase I (FabB ...
Youchao Deng, Yuling Li, Zhongqing Wen, Claudia H. Ruiz, Xiang Weng, Michael D. Cameron, Yanwen Duan, Yong Huang   +7 more
doaj   +1 more source

Acyl Carrier Protein

Journal of Biological Chemistry, 1973
Abstract A number of analogues of Escherichia coli apo-acyl carrier protein (apo-ACP) have been synthesized by the solid phase method. A standard isolation procedure was used for all analogues. This involved cleavage from the solid support and deprotection by treatment of the peptide-resin with hydrogen bromide and trifluoroacetic acid. The product was
Garland R. Marshall, P. Roy Vagelos, William S. Hancock   +2 more
openaire   +3 more sources