Results 31 to 40 of about 80,359 (315)

Acyl Carrier Protein

open access: yesJournal of Biological Chemistry, 1968
Abstract Acyl carrier protein holoprotein (holo-ACP) synthetase, an enzyme which transfers 4'-phosphopantetheine from reduced coenzyme A to acyl carrier protein apoprotein (apo-ACP) to form holo-ACP and 3',5'-adenosine diphosphate, has been shown in Escherichia coli B. At 780-fold purification the enzyme is free of apo-ACP, holo-ACP, and ACP hydrolase.
J Elovson, P R Vagelos
openaire   +3 more sources

The Mitochondrial Carnitine Acyl-carnitine Carrier (SLC25A20): Molecular Mechanisms of Transport, Role in Redox Sensing and Interaction with Drugs

open access: yesBiomolecules, 2021
The SLC25A20 transporter, also known as carnitine acyl-carnitine carrier (CAC), catalyzes the transport of short, medium and long carbon chain acyl-carnitines across the mitochondrial inner membrane in exchange for carnitine.
Annamaria Tonazzi   +4 more
doaj   +1 more source

Identifying Novel Inhibitors of RpFabG in Typhus-inducing Rickettsia prowazekii [PDF]

open access: yes, 2019
Epidemic typhus is a rickettsial disease that is contracted via ticks and lice found on the flying squirrel. The disease is caused by Rickettsia prowazekii, an intracellular, gram-negative coccobacillus.
Panatpur, Aparna
core   +1 more source

Versatility of Acyl-Acyl Carrier Protein Synthetases

open access: yesChemistry & Biology, 2014
The acyl carrier protein (ACP) requires posttranslational modification with a 4'-phosphopantetheine arm for activity, and this thiol-terminated modification carries cargo between enzymes in ACP-dependent metabolic pathways. We show that acyl-ACP synthetases (AasSs) from different organisms are able to load even, odd, and unnatural fatty acids onto E ...
Kara Finzel   +2 more
openaire   +3 more sources

Enhanced Rishirilide Biosynthesis by a Rare In-Cluster Phosphopantetheinyl Transferase in Streptomyces xanthophaeus

open access: yesMicrobiology Spectrum, 2022
Phosphopantetheinyl transferases (PPTases) play important roles in activating apo-acyl carrier proteins (apo-ACPs) and apo-peptidyl carrier proteins (apo-PCPs) in both primary and secondary metabolism. PPTases catalyze the posttranslational modifications
Songya Zhang   +7 more
doaj   +1 more source

The Nodulation Protein NodG Shows the Enzymatic Activity of an 3-Oxoacyl-Acyl Carrier Protein Reductase

open access: yesMolecular Plant-Microbe Interactions, 2001
The acyl carrier protein NodF is required for the synthesis of unusual polyunsaturated fatty acids that confer specificity to lipochitin oligosaccharide nodulation (Nod) factors of Rhizobium leguminosarum. In this study, homogeneous NodF protein was used
Isabel M. López-Lara, Otto Geiger
doaj   +1 more source

High temperature during soybean seed development differentially alters lipid and protein metabolism

open access: yesPlant Production Science, 2020
High temperatures during seed development can affect the seed yield and quality in many crops. Here, we analyzed how high temperature alters the main seed storage compounds (lipid and protein) in soybean. At five days after R5 stage (initial seed filling
Andressa C. S. Nakagawa   +7 more
doaj   +1 more source

The Acyl‐Carrier Protein of Citrate Lyase [PDF]

open access: yesEuropean Journal of Biochemistry, 1973
When [14C]acetyl citrate lyase was dissociated in sodium dodecylsulfate and the products were separated by gel electrophoresis, all of the radioactive label appeared in a small protein. This had a molecular weight of about 10000 and contained phosphopantetheine.
Peter Dimroth   +3 more
openaire   +3 more sources

Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase

open access: yesNature Communications, 2020
Acyl-acyl carrier protein reductase (AAR) and aldehyde deformylating oxygenase (ADO) are the two enzymes in a cyanobacterial alkane biosynthesis pathway that is of interest for biofuel production.
Yu Gao   +9 more
doaj   +1 more source

Morphing Natural Product Platensimycin via Heck, Sonogashira, and One-Pot Sonogashira/Cycloaddition Reactions to Produce Antibiotics with In Vivo Activity

open access: yesAntibiotics, 2022
Type II fatty acid synthases are promising drug targets against major bacterial pathogens. Platensimycin (PTM) is a potent inhibitor against β-ketoacyl-[acyl carrier protein] synthase II (FabF) and β-ketoacyl-[acyl carrier protein] synthase I (FabB ...
Youchao Deng   +7 more
doaj   +1 more source

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