Results 181 to 190 of about 103,057 (335)

Determination of Diketopiperazine Formation During the Solid‐Phase Synthesis of C‐Terminal Acid Peptides

Chemistry–Methods, EarlyView.
Diketopiperazine formation (DKP) is one of the most serious side reactions during peptide synthesis. An accurate method to determine the DKP formation in peptide synthesis on Wang resin is reported. Furthermore, the strategies to minimize this side reaction and side products lacking C‐terminal amino acids are described. Diketopiperazine formation (DKP)
Mani Kaushal, Ashish Kumar, Hassan Gamal, Sinenhlanhla N. Mthembu, Rotimi Sheyi, XiaoKang Kou, Beatriz G. de la Torre, Fernando Albericio   +7 more
wiley   +1 more source

4‐Methylbenzhydryl Bromine Resin: Bridging the Gap between 2‐Chlorotrityl Chloride and Wang‐Type Resins for the Solid‐Phase Synthesis of C‐Terminal Acid Peptides

Chemistry–Methods, EarlyView.
Methylbenzhydryl bromine resin give good performance in specific condition copared to wang and 2‐chlorotrityl chloride resin. Over the last year, peptides have been consolidated as an important class of biomolecules, receiving increased attention from the pharmaceutical, cosmetic, and food industries. Most peptides currently used in both industrial and
Hassan Gamal, Mani Kaushal, Ashish Kumar, Sikabwe Noki, Cheng Zhang, Chaoyang Wang, Xiaokang Kou, Alessandra Basso, Simona Serban, Beatriz G. de la Torre, Fernando Albericio   +10 more
wiley   +1 more source

The Synthesis of the Optically Active Polymers by the Acylation of Polyvinyl Alcohol with p-Toluenesulfonyl-Lvaline

, 1962
箕浦 有二, 迫田 直一
openalex   +2 more sources

Acylation of Enamines. III. Reduction of Protonated Enaminones with Sodium Borohydride. Synthesis of alpha,beta-Unsaturated Ketones. [PDF]

, 1979
Lars Nilsson, Bengt Thulin, Olof Wennerström, Curt R. Enzell, Åke Åkeson, Gunilla Lundquist   +5 more
openalex   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, EarlyView.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Deciphering protein long-chain <i>S</i>-acylation using mass spectrometry proteomics strategies. [PDF]

RSC Chem Biol
Nederstigt AE, Sardana S, Baggelaar MP.
europepmc   +1 more source

A Radical‐Based, Transition Metal‐Free Approach for Diaryl Ketone Synthesis

ChemSusChem, EarlyView.
A sustainable and scalable one‐pot route to diverse diaryl ketones is described, proceeding via a distinctive radical process between aryl halides and benzonitriles, initiated by KOtBu/DMA and driven by air as the sole oxidant. Free from transition metals, peroxides, and carbon monoxide, this catalyst‐free and selective method exhibits broad functional
Dongjie Wang, Jordan Garo, Yinpeng Wang, Jean‐Marc Sotiropoulos, Marc Taillefer   +4 more
wiley   +1 more source

Role of novel protein acylation modifications in sepsis. [PDF]

Front Immunol
Wang J, He A, Song L, Jiang W, Xu L, Zheng R, Yu J.   +6 more
europepmc   +1 more source

Ambident Ion. VI. Kinetical and Thermodynamical Control in the Acylation of β-Dicarbonyl Compounds. Acetylation of Benzoylacetone and Benzoylacetonate Anion [PDF]

, 1971
Masakazu Suama, Yukimichi Nakao, Katsuhiko Ichikawa   +2 more
openalex   +1 more source

Discovery of Some New Heterocyclic Systems from Carbene‐Based Reactions of Indigo and N‐Methyl Derivatives

European Journal of Organic Chemistry, EarlyView.
Accessing new heterocyclic structural space on exposure of indigo‐based substrates to carbene or carbenoid reactive intermediates is the key focus of this work. A number of unprecedented heterocyclic products have been discovered and their structures characterized.
Sarfaraz Ali Ghumro, Matthew J. Perry, Christopher Richardson, Stephen G. Pyne, John B. Bremner, Paul A. Keller   +5 more
wiley   +1 more source