Results 61 to 70 of about 103,057 (335)

Plasma membrane association by N-acylation governs PKG function in Toxoplasma gondii [PDF]

, 2017
Cyclic GMP (cGMP)-dependent protein kinase (protein kinase G [PKG]) is essential for microneme secretion, motility, invasion, and egress in apicomplexan parasites, However, the separate roles of two isoforms of the kinase that are expressed by some ...
Brown, Kevin M, Long, Shaojun, Sibley, L. David   +2 more
core   +2 more sources

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

1,4-diacetoxy-β-lactams. Reactions with nucleophiles [PDF]

, 1985
β-Lactam reacts with hetero nucleophiles under ring cleavage to give 2,2-dimethyl-3-oximinobutanoic esters 6 and 7 .
Elburg, P.A. van, Harkema, S., Hummel, G.J. van, Reinhoudt, D.N.   +3 more
core   +3 more sources

Supramolecular Chemistry in Metal–Organic Framework Materials

Advanced Materials, EarlyView.
This review highlights synergies between reticular chemistry and supramolecular chemistry. The role of supramolecular interactions in determining framework…guest interactions and attempts to understand dynamic behavior in metal–organic frameworks (MOFs), particularly emphasizing the development of crystal sponges, studying reactions in frameworks and ...
Eugenia Miguel‐Casañ, Georgia R. F. Orton, Danielle E. Schier, Neil R. Champness   +3 more
wiley   +1 more source

Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system

eLife, 2021
Protein acylation is critical for many cellular functions across all domains of life. In bacteria, lipoproteins have important roles in virulence and are targets for the development of antimicrobials and vaccines. Bacterial lipoproteins are secreted from
Christopher Icke, Freya J Hodges, Karthik Pullela, Samantha A McKeand, Jack Alfred Bryant, Adam F Cunningham, Jeff A Cole, Ian R Henderson   +7 more
doaj   +1 more source

Multifunctional Bamboo Based Materials Empowered by Multiscale Hierarchical Structures—A Critical Review

Advanced Materials, EarlyView.
This review summarizes the latest progress in transforming renewable bamboo resources into high‐value functional materials. It emphasizes how to leverage bamboo's multiscale hierarchical structures to realize innovative applications in energy, construction, environment, and medicine, providing key insights for developing high‐performance bio‐based ...
Yuxiang Huang, Juan Hu, Yahui Zhang, Yanglun Yu, Daihui Zhang, Qiumei Jing, Muhammad Wakil Shahzad, Saddick Donkor, Chi Chen, Chuan Wei Zhang, Ximin He, Ben Bin Xu, Shengbo Ge, Wenji Yu   +13 more
wiley   +1 more source

Juxta-membrane S-acylation of plant receptor-like kinases is likely fortuitous and does not necessarily impact upon function [PDF]

, 2019
This work was funded by UK Biotechnology and Biological Sciences Research Council Grants BB/M024911/1 and BB/M010996/1 to P.A.H.S-acylation is a common post-translational modification of membrane protein cysteine residues with many regulatory roles.
Hemsley, Piers, Hurst, Charlotte, Jones, Susan, Leslie , Kerry, Turnbull, Dionne, Wright, Kathryn M.   +5 more
core   +4 more sources

Unlocking the Essence of Lignin: High‐Performance Adhesives That Bond via Thiol‐Catechol Connectivities and Debond on Electrochemical Command

Advanced Materials, EarlyView.
A novel lignin‐inspired adhesive is presented, that combines the bonding strength of a structural adhesive with on‐demand electrochemical debonding, enabled by biomimetic thiol‐catechol connectivities. Voltage application of only 9 V facilitates electrochemical oxidation of catechols to quinones leading to guided detachment on command.
Keven Walter, Dominik P. Hoch, Leon Hertweck, Kannan Balasubramanian, Jonas Geisler, Mathias Röllig, Tilmann J. Neubert, Hans G. Börner   +7 more
wiley   +1 more source

Highly Efficient Regioselective Decanoylation of Hyperoside Using Nanobiocatalyst of Fe3O4@PDA-Thermomyces lanuginosus Lipase: Insights of Kinetics and Stability Evaluation

Frontiers in Bioengineering and Biotechnology, 2020
The immobilization of Thermomyces lanuginosus lipase on polydopamine-functionalized Fe3O4 magnetic nanoparticles (Fe3O4@PDA-TLL) as a nanobiocatalyst was successfully performed for the first time, and the Fe3O4@PDA-TLL was used for regioselective ...
Yanhong Bi, Yanhong Bi, Zhaoyu Wang, Yaoqi Tian, Haoran Fan, Shuo Huang, Yihui Lu, Zhengyu Jin   +7 more
doaj   +1 more source

Homeoviscous Adaptation of the Acinetobacter baumannii Outer Membrane: Alteration of Lipooligosaccharide Structure during Cold Stress

mBio, 2021
To maintain optimal membrane dynamics, cells from all domains of life must acclimate to various environmental signals in a process referred to as homeoviscous adaptation.
Carmen M. Herrera, Bradley J. Voss, M. Stephen Trent   +2 more
doaj   +1 more source