Results 81 to 90 of about 126,317 (283)
Synthesis and biological evaluation of novel PDMP analogues [PDF]
, 2006 A new series of hybrid PDMP analogues, based both on PDMP and styryl analogues of natural ceramide, has been synthesized from D-serine. The synthetic route was developed such that future introduction of different aryl groups is straightforward ...
Boldin-Adamsky, Swetlana +5 more
core +1 more source
Binding to medium and long chain fatty acyls is a common property of HEAT and ARM repeat modules. [PDF]
, 2019 Covalent post-translational modification (PTM) of proteins with acyl groups of various carbon chain-lengths regulates diverse biological processes ranging from chromatin dynamics to subcellular localization.
Chua, Katrin F +7 more
core +1 more source
The chemistry and applications of RNA 2′-OH acylation
Nature Reviews Chemistry, 2019 RNA is a versatile biomolecule with a broad range of biological functions that go far beyond its initially described role as a simple information carrier.
W. A. Velema, E. Kool
semanticscholar +1 more source
Biocatalysis as Useful Tool in Asymmetric Synthesis: An Assessment of Recently Granted Patents (2014–2019) [PDF]
, 2019 The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical fields are interconnected and synergized. A way to depict that innovation is by conducting a survey on patent activities.
Alcántara, Andrés R. +2 more
core +3 more sources
Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis. [PDF]
, 2015 Palmitic acid (PA) induces hepatocyte apoptosis and fuels de novo ceramide synthesis in the endoplasmic reticulum (ER). Myristic acid (MA), a free fatty acid highly abundant in copra/palmist oils, is a predictor of nonalcoholic steatohepatitis (NASH) and
Alarcón-Vila, C +9 more
core +2 more sources
HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance HDAC11 is the only class IV member of the histone deacetylase (HDAC) family, and very little is known about its biological function. The work here reveals its efficient and physiologically relevant activity.
Ji Cao +7 more
semanticscholar +1 more source
Kinetic proofreading at single molecular level: Aminoacylation of tRNA^{Ile} and the role of water as an editor [PDF]
, 2013 Proofreading/editing in protein synthesis is essential for accurate translation of information from the genetic code. In this article we present a theoretical investigation of efficiency of a kinetic proofreading mechanism that employs hydrolysis of the ...
Bagchi, Biman, Santra, Mantu
core +3 more sources
Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets.
TIBS -Trends in Biochemical Sciences. Regular ed, 2017 Post-translational attachment of lipids to proteins is found in all organisms, and is important for many biological processes. Acylation with myristic and palmitic acids are among the most common lipid modifications, and understanding reversible protein ...
Thomas Lanyon-Hogg +3 more
semanticscholar +1 more source
Journal of the American Oil Chemists' Society, EarlyView.ABSTRACT This study examined whether enzymatic modification of soybean oil (SBO) can be tailored to produce trans‐free fats with physicochemical properties comparable to palm olein, stearin, or palm‐mid fractions (PMFs). US‐grown SBO was modified by lipase‐catalyzed acidolysis using palmitic acid at linearly interpolated substrate molar ratios (C16:0 ...
Ityotagher P. Aondoakaa +2 more
wiley +1 more source
Asia-Pacific Journal of Chemical Engineering, EarlyView.ABSTRACT Biodegradable and low‐irritant amino acid–based surfactants have attracted considerable attention as environmentally friendly alternatives to conventional petroleum‐derived surfactants. In this study, a series of acyl amino acid surfactants with identical amino acid head groups but different alkyl chain lengths were synthesized via a modified ...
Toshihiro Takeshita +11 more
wiley +1 more source