Results 81 to 90 of about 89,225 (346)
Advanced Science, EarlyView.This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan +6 more
wiley +1 more source
Cationic, Aromatic Acyl Donors for Directing Protein Acylation Using non-Covalent Interactions [PDF]
Chemical acylation of biomolecules is one of the most important and fundamental bioconjugation reactions but generates statistical mixtures of conjugates that are difficult to control synthetically.
Michael, Taylor +3 more
core +1 more source
Palladium-Catalyzed Direct Acylation: One-Pot Relay Synthesis of Anthraquinones [PDF]
, 2019 A bis-acylation strategy to access functionalized anthraquinones via one-pot relay process, is presented. The first acylation was feasible under [Pd]-catalyzed intermolecular direct acylation reaction, while, the second acylation was accomplished by ...
Suchand, Basuli, G, Satyanarayana
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Glutathione‐Responsive Acyl‐Modifications for Targeted RNA Decaging and Prolonged Protein Synthesis
Angewandte Chemie, EarlyView.The self‐immolation of disulfide‐based mRNA modifications in response to endogenous glutathione (GSH) promotes a gradual release of translatable mRNA within the cell, leading to improved nuclease resistance, tunable release properties, and a significant increase (up to 600%) of target protein production over time. This strategy offers an exciting proof
Mary E. Flood +6 more
wiley +2 more sources
N-acylation of ethanolamine using lipase: a chemoselective catalyst
Beilstein Journal of Organic Chemistry, 2009 The N-acylation of ethanolamine (2) with various fatty acids 1a–d and esters of fatty acids 1e–h using Candida antarctica B lipase (Novozym® 435) are described and optimum conditions for selective N-acylation rather than O-acylation are also discussed ...
Mazaahir Kidwai +2 more
doaj +1 more source
Frontiers in Immunology, 2021 Phagocytosis is a receptor-mediated process used by cells to engulf a wide variety of particulates, including microorganisms and apoptotic cells. Many of the proteins involved in this highly orchestrated process are post-translationally modified with ...
Charneal L. Dixon +7 more
doaj +1 more source
Advanced Science, EarlyView.The TPR‐LYTACs nanomaterial offers a dual‐pathway strategy for precise gouty arthritis treatment by targeting and degrading the ROS‐producing enzyme NOX2 inside macrophages while its antioxidant core clears accumulated ROS outside. This “source inhibition and microenvironment scavenging” approach, guided by NIR‐II imaging, effectively controls local ...
Jian Zhang +15 more
wiley +1 more source
An efficient acylation of anilines under sonic conditions [PDF]
, 2003 Different substituted anilines undergo smooth acylation to give anilides within 60 s in high yields by irradiating at 35 kHz in a sonic bath at 25°C with different acyl ...
Pasha, M.A., Yi Yi Myint, .
core
Advanced Science, EarlyView.This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai +12 more
wiley +1 more source
, 2011 Innerhalb von Zellen ist die Verteilung von Proteinen häufig präzise, das bedeutet mit spezifischer Anreicherung in verschiedenen intrazellulären Kompartimenten.
Vartak, Nachiket
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