Results 1 to 10 of about 10,400 (184)

SGLT2 inhibition, acylcarnitines and heart failure: a Mendelian randomization study [PDF]

Open Heart
Objective Sodium-glucose cotransporter 2 (SGLT2) inhibitors are guideline-recommended agents for treating heart failure (HF), but the role of metabolomic biomarkers in underlying mechanisms, particularly acylcarnitines, remains unclear.
Liming Li, Zhengming Chen, Junshi Chen, Ling Yang, Dianjianyi Sun, Hong Guo, Jun Lv, Yiping Chen, Dan Schmidt, Xiaoming Yang, Pei Pei, Canqing Yu, Yuanjie Pang, Iona Y Millwood, Robin G Walters, Zhiyu Wu, Shuyao Song   +16 more
doaj   +2 more sources

Paediatric CSF acylcarnitine reference ranges [PDF]

Frontiers in Molecular Biosciences
Acylcarnitines play a crucial role in energy metabolism pathways, primarily known for their involvement in the beta oxidation of fatty acids. However, their roles extend beyond mitochondrial transport; they also contribute to the synthesis of lipids in ...
Ontefetse Neo Plaatjie, A. Marceline Tutu Van Furth, A. Marceline Tutu Van Furth, Regan Solomons, Martijn Van Der Kuip, Shayne Mason   +5 more
doaj   +2 more sources

The Effect of Acylcarnitines on Cognitive Function: A Two‐Sample Mendelian Randomization Study [PDF]

Brain and Behavior
Objective Clinical trials investigating the association between acylcarnitines and cognitive function have yielded conflicting results. We conducted a Mendelian randomization (MR) study to examine the causal associations between 20 acylcarnitines and ...
Sisi Luan, Jinyan Zhang, Chenglong Wang, Ziqi Wang, Jianbo Zhou   +4 more
doaj   +2 more sources

Serum acylcarnitines profile at ICU discharge to predict mid-term muscle outcomes: an exploratory study [PDF]

Frontiers in Medicine
BackgroundAlterations in acylcarnitines (AC) profile may reflect mitochondrial and metabolic disturbances after critical illness. This study investigated the association between AC profile at ICU discharge (ICUD) and muscle outcomes assessed 3 months (M3)
Anne-Françoise Rousseau, Anne-Françoise Rousseau, Frédéric Farnir, Etienne Cavalier, Géraldine Luis, Isabelle Kellens, Bernard Lambermont, François Boemer   +7 more
doaj   +2 more sources

The association between acylcarnitine and amino acids profile and metabolic syndrome and its components in Iranian adults: Data from STEPs 2016

Frontiers in Endocrinology, 2023
BackgroundEvidence, albeit with conflicting results, has suggested that cardiometabolic risk factors, including obesity, type 2 diabetes (T2D), dyslipidemia, and hypertension, are highly associated with changes in metabolic signature, especially plasma ...
Hananeh Taghizadeh, Solaleh Emamgholipour, Shaghayegh Hosseinkhani, Babak Arjmand, Negar Rezaei, Arezou Dilmaghani-Marand, Erfan Ghasemi, Nekoo Panahi, Hojat Dehghanbanadaki, Robabeh Ghodssi-Ghassemabadi, Niloufar Najjar, Mojgan Asadi, Mohsen khoshniat, Bagher Larijani, Farideh Razi   +14 more
doaj   +1 more source

Diagnostic Challenges in Late Onset Multiple Acyl-CoA Dehydrogenase Deficiency: Clinical, Morphological, and Genetic Aspects

Frontiers in Neurology, 2022
BackgroundMultiple acyl-CoA dehydrogenase deficiency (MADD) is an autosomal recessive disorder of fatty acid oxidation due to deficiency of the mitochondrial electron transfer chain.
Antonino Lupica, Rosaria Oteri, Sara Volta, Daniele Ghezzi, Daniele Ghezzi, Selene Francesca Anna Drago, Carmelo Rodolico, Olimpia Musumeci, Antonio Toscano   +8 more
doaj   +1 more source

Serum Metabolite Profile Associated with Sex-Dependent Visceral Adiposity Index and Low Bone Mineral Density in a Mexican Population

Metabolites, 2021
Recent evidence shows that obesity correlates negatively with bone mass. However, traditional anthropometric measures such as body mass index could not discriminate visceral adipose tissue from subcutaneous adipose tissue.
Berenice Palacios-González, Guadalupe León-Reyes, Berenice Rivera-Paredez, Isabel Ibarra-González, Marcela Vela-Amieva, Yvonne N. Flores, Samuel Canizales-Quinteros, Jorge Salmerón, Rafael Velázquez-Cruz   +8 more
doaj   +1 more source

Plasma acylcarnitines could predict prognosis and evaluate treatment of IgA nephropathy

Nutrition & Metabolism, 2019
Background Effective evaluation or prediction of therapy response could be helpful for treatment of chronic kidney disease (CKD), which may rely on accurate biomarkers. Acylcarnitines are involved with lipid metabolism and mitochondrial function.
Fang-Ying Xia, Li Zhu, Chao Xu, Qing-Qing Wu, Wan-Jia Chen, Rong Zeng, Yue-Yi Deng   +6 more
doaj   +1 more source

Quantitative analysis of plasma acylcarnitines using gas chromatography chemical ionization mass fragmentography.

Journal of Lipid Research, 1997
A stable isotope dilution gas chromatography chemical ionization mass spectrometry (GC-CI-MS) method was developed for the quantitative profiling of plasma acylcarnitines.
C G Costa, E A Struys, A Bootsma, H J ten Brink, L Dorland, I Tavares de Almeida, M Duran, C Jakobs   +7 more
doaj   +1 more source

Sexual Dimorphism in Energy Metabolism of Wistar Rats Using Data Analysis

Molecules, 2020
The prevalence of some chronic diseases, such as cancer or neurodegenerative disorders, differs between sexes. Animal models provide an important tool to adopt potential therapies from preclinical studies to humans.
Andrea Leskanicova, Olga Chovancova, Marian Babincak, Ludmila Verboova, Zuzana Benetinova, Denisa Macekova, Jozef Kostolny, Benadik Smajda, Terezia Kiskova   +8 more
doaj   +1 more source