Results 11 to 20 of about 10,400 (184)

Acylcarnitine profile analysis [PDF]

Genetics in Medicine, 2008
These Technical Standards and Guidelines were developed primarily as an educational resource for clinical laboratory geneticists to help them provide quality clinical laboratory genetic services. Adherence to these standards and guidelines is voluntary and does not necessarily assure a successful medical outcome.
Piero, Rinaldo, Tina M, Cowan, Dietrich, Matern   +2 more
openaire   +2 more sources

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Metabolic Pathways of Acylcarnitine Synthesis

Physiological Research, 2023
Acylcarnitines are important markers in metabolic studies of many diseases, including metabolic, cardiovascular, and neurological disorders. We reviewed analytical methods for analyzing acylcarnitines with respect to the available molecular structural information, the technical limitations of legacy methods, and the potential of new mass spectrometry ...
Jana Brejchova, Kristyna Brejchova, Ondrej Kuda   +2 more
openaire   +3 more sources

Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues [PDF]

Scientific Reports, 2017
AbstractIncreased plasma concentrations of acylcarnitines (ACs) are suggested as a marker of metabolism disorders. The aim of the present study was to clarify which tissues are responsible for changes in the AC pool in plasma. The concentrations of medium- and long-chain ACs were changing during the fed-fast cycle in rat heart, muscles and liver. After
Marina Makrecka-Kuka, Eduards Sevostjanovs, Karlis Vilks, Kristine Volska, Unigunde Antone, Janis Kuka, Elina Makarova, Osvalds Pugovics, Maija Dambrova, Edgars Liepinsh   +9 more
openaire   +2 more sources

Acquired Multiple Acyl-Coenzyme A Dehydrogenase Deficiency Associated With Sertraline in Sweden-A Nationwide Population-Based Study. [PDF]

Eur J Neurol
Multiple acyl‐coenzyme A dehydrogenase deficiency‐like disease has recently been described as a rare adverse effect of sertraline. We performed a nationwide population‐based retrospective study in Sweden (2014–2024) including 40 patients, corresponding to an incidence of 1.24 per 100,000 treated individuals per year.
Sunebo S, Nilsson E, Engvall M, Hedberg-Oldfors C, Shen Y, Nennesmo I, Danielsson O, Oldfors A, Appelqvist H, Lindgren U.   +9 more
europepmc   +2 more sources

A Multi-Organ Atlas Links Gut Microbial Metabolites to Systemic Redox Changes in Aging Mice. [PDF]

Aging Cell
A gut‐derived metabolic signature drives systemic aging phenotypes. Integrated multi‐omics profiling of young versus aged mice identifies a conserved aging signature characterized by the depletion of protective lysophosphatidylcholines (LPC 22:0) and the concurrent accumulation of pro‐oxidative microbial catabolites (TMAO, IAA).
Sajid S, Huang J, Kong S, Lai C, Tan Z, Shao Y, Guo L.   +6 more
europepmc   +2 more sources

Increasing maternal age associates with lower placental CPT1B mRNA expression and acylcarnitines, particularly in overweight women

Frontiers in Physiology, 2023
Older pregnant women have increased risks of complications including gestational diabetes and stillbirth. Carnitine palmitoyl transferase (CPT) expression declines with age in several tissues and is linked with poorer metabolic health. Mitochondrial CPTs
Hannah E. J. Yong, Oliver C. Watkins, Tania K. L. Mah, Victoria K. B. Cracknell-Hazra, Victoria K. B. Cracknell-Hazra, Reshma Appukuttan Pillai, Preben Selvam, Mohammad O. Islam, Neha Sharma, Amaury Cazenave-Gassiot, Amaury Cazenave-Gassiot, Anne K. Bendt, Markus R. Wenk, Markus R. Wenk, Keith M. Godfrey, Keith M. Godfrey, Rohan M. Lewis, Rohan M. Lewis, Shiao-Yng Chan, Shiao-Yng Chan   +19 more
doaj   +1 more source

Function, Detection and Alteration of Acylcarnitine Metabolism in Hepatocellular Carcinoma

Metabolites, 2019
Acylcarnitines play an essential role in regulating the balance of intracellular sugar and lipid metabolism. They serve as carriers to transport activated long-chain fatty acids into mitochondria for β-oxidation as a major source of energy for cell ...
Shangfu Li, Dan Gao, Yuyang Jiang
doaj   +1 more source

Dynamics of acylcarnitines, hypoglycin A, méthylènecyclopropylglycine and their metabolites in a Kladruber stallion with atypical myopathy

Veterinary Quarterly, 2022
Equine atypical myopathy (AM also referred to as multiple acyl-CoA dehydrogenases deficiency [MADD]) is thought to be caused by toxins metabolized from hypoglycin A (HGA) and méthylènecyclopropylglycine (MCPrG).
Petr Jahn, Dana Dobešová, Radana Brumarová, Katarína Tóthová, Andrea Kopecká, David Friedecký   +5 more
doaj   +1 more source

Tissue Specific Distribution and Activation of Sapindaceae Toxins in Horses Suffering from Atypical Myopathy

Animals, 2023
Equine atypical myopathy is caused by hypoglycin A (HGA) and methylenecyclopropylglycine (MCPrG), the known protoxins of sycamore maple (Acer pseudoplatanus). Various tissues from five atypical myopathy cases were analyzed but only HGA was found. Whether
Johannes Sander, Michael Terhardt, Nils Janzen, Benoît Renaud, Caroline-Julia Kruse, Anne-Christine François, Clovis P. Wouters, François Boemer, Dominique-Marie Votion   +8 more
doaj   +1 more source