Results 51 to 60 of about 10,400 (184)

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Stearoyl-CoA desaturase 1 deficiency drives saturated lipid accumulation and increases liver and plasma acylcarnitines

Journal of Lipid Research
Stearoyl-CoA desaturase-1 (SCD1) is a critical regulator of lipogenesis that catalyzes the synthesis of MUFAs, mainly oleate (18:1n-9) and palmitoleate (16:1n-7) from saturated fatty acids, stearoyl-CoA (18:0) and palmitoyl-CoA (16:0), respectively ...
Mugagga Kalyesubula, Helaina Von Bank, Jessica W. Davidson, Maggie S. Burhans, Madelaine M. Becker, Ahmed Aljohani, Judith Simcox, James M. Ntambi   +7 more
doaj   +1 more source

Correlation between Acylcarnitine and Peripheral Neuropathy in Type 2 Diabetes Mellitus

Journal of Diabetes Research, 2022
Objective. In patients with type 2 diabetes mellitus (T2DM), it is unknown whether acylcarnitine changes in the patient’s plasma as diabetic peripheral neuropathy (DPN) occurs.
Zhenni An, Danmeng Zheng, Dongzhuo Wei, Dingwen Jiang, Xuejiao Xing, Chang Liu   +5 more
doaj   +1 more source

Longitudinal metabolomics study of phosphate-adenine-guanosine-glucose-saline-mannitol stored red blood cells. [PDF]

Transfusion
Abstract Background The storage of red blood cells (RBCs) is essential for transfusion but leads to storage lesions that compromise RBC quality and increase the risk of transfusion‐related adverse effects, including allergic transfusion reactions (ATRs). Understanding storage‐induced metabolic change is crucial for enhancing transfusion safety.
Bal G, Dzamashvili M, Li Z, Babina M, Toman N, Salama A.   +5 more
europepmc   +2 more sources

Family history and obesity in youth, their effect on acylcarnitine/aminoacids metabolomics and non-alcoholic fatty liver disease (NAFLD). Structural equation modeling approach. [PDF]

PLoS ONE, 2018
Structural equation modeling (SEM) can help understanding complex functional relationships among obesity, non-alcoholic fatty liver disease (NAFLD), family history of obesity, targeted metabolomics and pro-inflammatory markers.
Maria Elena Romero-Ibarguengoitia, Felipe Vadillo-Ortega, Augusto Enrique Caballero, Isabel Ibarra-González, Arturo Herrera-Rosas, María Fabiola Serratos-Canales, Mireya León-Hernández, Antonio González-Chávez, Srinivas Mummidi, Ravindranath Duggirala, Juan Carlos López-Alvarenga   +10 more
doaj   +1 more source

Mechanism of carnitine acylcarnitine translocase-catalyzed import of acylcarnitines into mitochondria.

Journal of Biological Chemistry, 1984
Mitochondrial imports of acylcarnitine and carnitine have been measured by new methods based on the monitoring of deacylation of acylcarnitines and the acetylation of carnitine in the matrix, subsequent to their entry. These methods have shown higher import rates than those calculated from the uptake of radioactive carnitines into mitochondria as ...
M S, Murthy, S V, Pande
openaire   +2 more sources

Pyridoxal Reprograms Peroxisomal Hydrogen Peroxide Metabolism to Induce Lethal Oxidative Stress in Ovarian Cancer

iMetaMed, EarlyView.
Pyridoxal (PL) exhibits the strongest anti‐tumor activity within the vitamin B6 family, demonstrating significant ovarian cancer cell‐killing efficacy in vivo, in vitro, and in patient‐derived organoid (PDO) models. The anti‐tumor mechanism involves PL inducing a shift in peroxisome dynamics towards fission, promoting peroxisome proliferation, and ...
Ruonan Li, Huiyan Wang, Dunke Zhang, Qiuying Gu, Jinlong Wang, Bin Liu, Huabin Gao, Jingya Duan, Yimin Liu, Xiaolan Huang, Youquan Bu, Tongchuan He, Hua Linghu   +12 more
wiley   +1 more source

Serum Acylcarnitines and Vitamin B12 Deficiency [PDF]

Clinical Chemistry, 2002
Measurements of acylcarnitines in plasma have several diagnostic applications, and various tandem mass spectrometry methods are more specific and accurate than earlier methods (1)(2)(3)(4). Libert et al. (5) reported that propionylcarnitine (PrCRN) and carnitine (CRN) esters of 2-methyl-branched fatty acids with chain lengths of four to nine carbons ...
Mark M, Kushnir, Bori, Shushan, William L, Roberts, Marzia, Pasquali   +3 more
openaire   +2 more sources

Acylcarnitines in Ophthalmology: Promising Emerging Biomarkers

International Journal of Molecular Sciences, 2022
Several common ocular diseases are leading causes of irreversible visual impairment. Over the last decade, various mainly untargeted metabolic studies have been performed to show that metabolic dysfunction plays an important role in the pathogenesis of ocular diseases. A number of metabolites in plasma/serum, aqueous or vitreous humor, or in tears have
Konstantinos Theodoridis, Helen Gika, Antigoni Kotali   +2 more
openaire   +2 more sources