Results 61 to 70 of about 10,947 (199)

Circadian rhythms of metabolite abundance in Drosophila are largely driven by time of feeding

The FEBS Journal, EarlyView.
Circadian clocks exist in the brain and peripheral tissues such as the Drosophila fat body. Single‐nuclei transcriptomics reveal that the fat body clock generates time‐of‐day differences in metabolic gene transcription, which may also be indirectly controlled by brain clocks.
Sumit Saurabh, Charlene Y. P. Guerrero, Madelyn R. Cusick, Amanda J. Samaras, Taylor M. Stephenson, Sebastian L. Kirkpatrick, Gregory J. Matthews, Daniel J. Cavanaugh   +7 more
wiley   +1 more source

Plasma acylcarnitines are associated with pulmonary hypertension [PDF]

Pulmonary Circulation, 2017
Quantifying metabolic derangements in pulmonary hypertension (PH) by plasma metabolomics could identify biomarkers useful for diagnosis and treatment. The objective of this paper is to test the hypotheses that circulating metabolites are differentially expressed in PH patients compared with controls and among different hemodynamic subtypes of PH ...
Luo, Nancy, Craig, Damian, Ilkayeva, Olga, Muehlbauer, Michael, Kraus, William E., Newgard, Christopher B., Shah, Svati H., Rajagopal, Sudarshan   +7 more
openaire   +2 more sources

Pemafibrate Improves Cholestatic Markers Regardless of the Presence of Primary Biliary Cholangitis

Hepatology Research, EarlyView.
Pemafibrate improves liver function markers related to bile flow in primary biliary cholangitis (PBC), but whether this effect is disease‐specific remains unclear. In this study, pemafibrate reduced these markers in patients with and without PBC, suggesting broader effects on bile flow beyond PBC.
Ryohei Tanigawa, Yoshiyuki Ueno, Hirokazu Takahashi, Ayumi Saito, Hideki Suganami, Atsushi Tanaka   +5 more
wiley   +1 more source

Association of BCAAs/BCKAs with pancreatic steatosis in patients with type 2 diabetes mellitus: A cross‐sectional study

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims To examine the association between branched‐chain α‐keto acids (BCKAs) and pancreatic steatosis in patients with type 2 diabetes (T2DM). Methods This cross‐sectional study was conducted from January 2023 to March 2025. Upper abdominal computerized tomography was performed, pancreatic volume (PV), PV index (PVI), CT attenuation of pancreas
Jie Gao, Pijun Cheng, Fusong Jiang, Wenmin Li, Yingying Shi, Wenjun Wang, Liang Wang, Tao Lei, Yunxiang Zang, Jun Lu   +9 more
wiley   +1 more source

Established and Emerging Biomarkers to Characterize Persons at Risk for Obesity—Paving the Way for Targeted Clinical Intervention Trials—A Comprehensive Position Paper

Obesity Reviews, EarlyView.
ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid, Victoria Stopa, Laurent Malisoux, Yvan Devaux, Elsa Lamy, Fernando Capela e Silva, Sarah Forberger, Tiziana de Magistris, Antoni Sureda, Margalida Monserrat‐Mesquida, Maria Pérez‐Jiménez, Rajini Nagrani, Maria Giovanna Onorati, Michele Filippo Fontefrancesco, Jonathan Turner, Mahesh S. Desai, Josep Tur, Cristina Bouzas, Gino Gabriel Bonetti, Oliver Riedel, Gitte Ravn‐Haren, Rikke Andersen, Torsten Bohn   +22 more
wiley   +1 more source

Temporal and interanimal variation in bloodspot acylcarnitine and amino acid profiles in relation to conventional metabolites and hormones in Holstein dairy cows

Journal of Dairy Science
: The transition from late gestation to early lactation in dairy cows involves dynamic metabolic adaptations orchestrated by homeorhetic mechanisms, including hepatic fatty acid and AA metabolism.
Pius Lutakome, Stijn Heirbaut, Muluken Mulat Girma, Mingqi Zhang, Xiaoping Jing, Karolien Hertogs, Katleen Geerinckx, Els Stevens, Ben Aernouts, Leen Vandaele, Denis Asizua, Fred Kabi, Veerle Fievez   +12 more
doaj   +1 more source

Metabolic pattern across energy imbalance: An exploratory metabolomics study of female body weight extremes including anorexia nervosa and athletes

Experimental Physiology, EarlyView.
Abstract In anorexia nervosa (AN), prolonged metabolic adaptation to severe energy deficiency can impair treatment efficacy. Similarly, low energy availability poses a recognized risk to athletes, potentially compromising health and performance. This cross‐sectional study aimed to characterize the plasma metabolic pattern of females with varying ...
Sonja Lackner, Olli Kärkkäinen, Sabrina Mörkl, Wolfram Müller, Alfred Fürhapter‐Rieger, Kati Hanhineva, Sandra Johanna Holasek   +6 more
wiley   +1 more source

Integrated multi-omics reveals acylcarnitine accumulation as an early driver of doxorubicin-induced cardiotoxicity targeted by chlorogenic acid

Frontiers in Pharmacology
IntroductionDoxorubicin (DOX)-induced cardiotoxicity (DIC) is a major clinical challenge, with early metabolic reprogramming acting as a potential pathogenic driver.
Jing Ren, Jing Ren, Yibo Yang, Guangdong Li, Huiying Sha, Bing Wang, Yin Wang, Ning Cui, Taoyan Liu   +8 more
doaj   +1 more source

Acute exercise‐induced lipolysis and increase in levels of fatty acid esters of hydroxy fatty acids in adipose tissue are impaired in obese and aged mice

Experimental Physiology, EarlyView.
Abstract Improving adipose tissue (AT) metabolism through exercise might increase production of lipokines from the fatty acid esters of hydroxy fatty acids (FAHFA) family. Although exercise training can increase insulin sensitivity and levels of specific FAHFA in AT and the circulation in humans, the effects of acute exercise on FAHFA levels remain ...
Marko Mitrovic, Olga Horakova, Martin Riecan, Veronika Kleinova, Tomas Cajka, Lenka Rossmeislova, Ondrej Kuda, Martin Rossmeisl   +7 more
wiley   +1 more source

Mechanism‐Informed Pharmacotherapy Optimization and Deprescribing: A Redox–Mitochondrial Framework

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
From cumulative drug burden to mitochondrial stress and functional decline. The graphical abstract summarizes the central concept of the review, illustrating how cumulative pharmacotherapy exposure may contribute to redox–mitochondrial stress and thereby reduce biological and functional resilience.
Boštjan Martinc
wiley   +1 more source