Results 1 to 10 of about 63,165 (207)
Structure and mechanism of human diacylglycerol O-acyltransferase 1
Nature, 2020 Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans1. DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all ...
Arthur Laganowsky +2 more
exaly +2 more sources
Crystal structure of a membrane-bound O-acyltransferase
Nature, 2018 Membrane-bound O-acyltransferases (MBOATs) are a superfamily of integral transmembrane enzymes that are found in all kingdoms of life1. In bacteria, MBOATs modify protective cell-surface polymers.
Zhizhi Wang, Peilong Lu, Houra Merrikh
exaly +2 more sources
Frontiers in Plant Science, 2017 Glycerol-3-phosphate acyltransferase is the first acyl esterifying enzyme in phosphatidylglycerol (PG) synthesis process. In this study, we isolated and characterized the glycerol-3-phosphate acyltransferase (GPAT) gene from Suaeda salsa (S.
Na Sui, Hai Fan
exaly +2 more sources
Frontiers in Plant Science, 2019 Microalgal lipids are promising feedstocks for food and biofuels. Since lipid production by microalgae is not yet economically feasible, genetic engineering is becoming a promising strategy to achieve higher lipid accumulation and productivities. Enzymes
Ruud A Weusthuis, Sarah D'adamo
exaly +2 more sources
The Uncommon Enzymology of Cis-Acyltransferase Assembly Lines
Chemical Reviews, 2017 The enzymology of 135 assembly lines containing primarily cis-acyltransferase modules is comprehensively analyzed, with greater attention paid to less common phenomena. Diverse online transformations, in which the substrate and/or product of the reaction
Adrian T Keatinge-clay
exaly +2 more sources
Versatility in acyltransferase activity completes chicoric acid biosynthesis in purple coneflower
Nature Communications, 2021 Purple coneflower (Echinacea purpurea (L.) Moench) is a popular native North American herbal plant. Its major bioactive compound, chicoric acid, is reported to have various potential physiological functions, but little is known about its biosynthesis ...
Rao Fu +7 more
semanticscholar +1 more source
Applications and prospects of genome editing in plant fatty acid and triacylglycerol biosynthesis
Frontiers in Plant Science, 2022 Triacylglycerol (TAG), which is a neutral lipid, has a structure in which three molecules of fatty acid (FA) are ester-bonded to one molecule of glycerol. TAG is important energy source for seed germination and seedling development in plants.
Mid-Eum Park, Hyun Uk Kim, Hyun Uk Kim
doaj +1 more source
The structural basis for the phospholipid remodeling by lysophosphatidylcholine acyltransferase 3
Nature Communications, 2021 As the major component of cell membranes, phosphatidylcholine (PC) is synthesized de novo in the Kennedy pathway and then undergoes extensive deacylation-reacylation remodeling via Lands’ cycle.
Qing Zhang +14 more
semanticscholar +1 more source
Frontiers in Plant Science, 2021 Polyacylated anthocyanins with multiple glycosyl and aromatic acyl groups tend to make flowers display bright and stable blue colours. However, there are few studies on the isolation and functional characterization of genes involved in the polyacylated ...
Chenfei Lu +7 more
doaj +1 more source