Results 141 to 150 of about 86,883 (336)

A selective decrease in mitochondrial glycerol phosphate acyltransferase activity in livers from streptozotocin‐diabetic rats [PDF]

, 1977
Edna J. Bates, David Saggerson
openalex   +1 more source

Akkermansia muciniphila‐derived hypoacylated rough‐type lipopolysaccharides alleviate diet‐induced obesity via activation of TLR4−IL‐23−IL‐22 immune axis

iMeta, EarlyView.
This study demonstrates that hypoacylated, rough‐type lipopolysaccharides (LPS) derived from Akkermansia muciniphila strain HW07 (ALPS) alleviates diet‐induced obesity. ALPS acts as a weak TLR4 agonist and significantly reduces weight gain, improves metabolic parameters, and restores gut barrier integrity in obese mice.
Li Sun, Yuting Zhang, Wang Dong, Jingzu Sun, Tao Wang, Fei Shao, Huanqin Dai, Junjie Han, Wenzhao Wang, Shuo Wang, Tong Zhao, Liangliang Wang, Chang Liu, Shuangjiang Liu, Hongwei Liu   +14 more
wiley   +1 more source

Multiomics Reveal Associations Between CpG Methylation, Histone Modifications and Transcription in a Species That has Lost DNMT3, the Colorado Potato Beetle

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Despite lacking DNMT3, EM‐seq revealed CpG methylation in the Colorado potato beetle. CUT&Tag analysis showed an association of H3K36me3 and H3K27ac with transcription, with H3K36me3 mirroring CpG methylation, demonstrating epigenetic flexibility.
Zoe M. Länger, Elisa Israel, Jan Engelhardt, Agata I. Kalita, Claudia I. Keller Valsecchi, Joachim Kurtz, Sonja J. Prohaska   +6 more
wiley   +1 more source

Reduced Esterification Rather Than Increased Hydrolysis Is Causative for Loss of Hepatic Retinoids Upon CCl₄-Induced Liver Injury. [PDF]

Liver Int
ABSTRACT Background and Aims Advanced liver disease leads to liver fibrosis that is characterised by the activation of non‐parenchymal stellate cells, accumulation of extracellular matrix proteins, and the loss of hepatic vitamin A stores. To date, the molecular mechanisms and enzymes mediating the loss of hepatic vitamin A stores are incompletely ...
Wagner C, Košić K, Bulfon D, Breithofer J, Jamnik A, Zitta C, Horvat P, Bilweis K, Schupp M, Zimmermann R, Taschler U, Lass A.   +11 more
europepmc   +2 more sources

Total parenteral nutrition and carnitine supplementation practices in preterm neonates - results of a national survey [PDF]

, 2013
Thesis (M.A.)--Boston UniversityBackground: The goal of postnatal total parenteral nutrition (TPN) in premature neonates (PT) is to mimic the intrauterine environment of the fetus. Micronutrients are essential for optimal development.
Khalid, Sabeen
core   +1 more source

A study of the glycerol phosphate acyltransferase and dihydroxyacetone phosphate acyltransferase activities in rat liver mitochondrial and microsomal fractions. Relative distribution in parenchymal and non-parenchymal cells, effects of N-ethylmaleimide, palmitoyl-coenzyme A concentration, starvation, adrenalectomy and anti-insulin serum treatment [PDF]

, 1979
Edna J. Bates, E D Saggerson
openalex   +1 more source

GNPAT/USP30 Stabilizes DRP1 Protein to Promote Mitochondrial Fission and Functional Damage in COPD Progression

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Our previous study revealed the role of glycerol phosphate O‐acyltransferase (GNPAT) in regulating chronic obstructive pulmonary disease (COPD). However, its further mechanisms remained unclear. In this study, COPD models were established by exposing mice to cigarette smoke particulates.
Xin‐Gui Cheng, Yun‐Chan Liu, Fei Chen, Ji‐Wei Li, Xiao‐Zhou Yao, Qing‐Yun Chen   +5 more
wiley   +1 more source

Ferroptosis in Pneumoconiosis: From Molecular and Cellular Mechanisms to Therapeutic Strategies

Med Research, EarlyView.
Targeting lung various cells to alleviate pneumoconiosis by suppressing ferroptosis. AAV9‐HGF, adeno‐associated virus‐hepatocyte growth factor; DFP, deferiprone; DHQ, dihydroquercetin; Fer‐1, ferrostatin‐1; IL‐1β, interleukin‐1β; NMN, nicotinamide mononucleotide; sh‐SLC39A14, shRNA targeting solute carrier family 39 member 14; si‐OC‐STAMP, siRNA ...
Mengli Yan, Jing Zhang, Gaili Ji, Xiaobin Fang, Chunheng Mo   +4 more
wiley   +1 more source

Postprandial Metabolism, Inflammation, and Plasma Bile Acid Kinetics in a Rat Model: Implications for Translational Research

Molecular Nutrition &Food Research, EarlyView.
Sprague‐Dawley rats were used to investigate postprandial metabolic and inflammatory responses following the consumption of an energy‐dense meal. Time‐resolved plasma and liver analyses revealed fluctuations in bile acid levels, particularly cholic acid, along with changes in metabolic intermediates, oxylipins, and inflammatory markers.
Larissa Rodrigues, Carlos M. Donado‐Pestana, Tushar More, Mar Garcia‐Aloy, Gustavo M. Carneiro de Lima, Lucas X. Martins de Oliveira, Urska Vrhovsek, Karsten Hiller, Jarlei Fiamoncini   +8 more
wiley   +1 more source

A facile assay for zDHHC palmitoyl transferase activation elucidates effects of mutation and modification

Journal of Lipid Research
At least 10% of proteins constituting the human proteome are subject to S-acylation by a long-chain fatty acid, thioesterified to a Cys thiol side chain.
Naoko Adachi, Douglas T. Hess, Takehiko Ueyama   +2 more
doaj   +1 more source