Results 11 to 20 of about 101,485 (290)
Glycerophosphate/Acylglycerophosphate Acyltransferases [PDF]
Biology, 2014 Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol (TAG) and glycerophospholipids.
Atsushi Yamashita +6 more
doaj +3 more sources
The Structure and Function of Acylglycerophosphate Acyltransferase 4/ Lysophosphatidic Acid Acyltransferase Delta (AGPAT4/LPAATδ) [PDF]
Frontiers in Cell and Developmental Biology, 2019 Lipid-modifying enzymes serve crucial roles in cellular processes such as signal transduction (producing lipid-derived second messengers), intracellular membrane transport (facilitating membrane remodeling needed for membrane fusion/fission), and protein
Mikhail A. Zhukovsky +4 more
doaj +4 more sources
The plasma lecithin:cholesterol acyltransferase reaction
Journal of Lipid Research, 1968 Evidence for the existence of a plasma lecithin: cholesterol acyltransferase is reviewed with emphasis not only on the lipid reactants, but also on the lipoprotein “substrates” and “products.” The cholesteryl esters of all major lipoprotein classes ...
John A. Glomset
doaj +4 more sources
Structure, mechanism, and inhibition of Hedgehog acyltransferase [PDF]
Molecular Cell, 2021 The Sonic Hedgehog (SHH) morphogen pathway is fundamental for embryonic development and stem cell maintenance and is implicated in various cancers. A key step in signaling is transfer of a palmitate group to the SHH N terminus, catalyzed by the multi-pass transmembrane enzyme Hedgehog acyltransferase (HHAT).
Claire E. Coupland +14 more
semanticscholar +6 more sources
The structural basis for the phospholipid remodeling by lysophosphatidylcholine acyltransferase 3
Nature Communications, 2021 As the major component of cell membranes, phosphatidylcholine (PC) is synthesized de novo in the Kennedy pathway and then undergoes extensive deacylation-reacylation remodeling via Lands’ cycle.
Qing Zhang +14 more
semanticscholar +1 more source
HBO1 is a versatile histone acyltransferase critical for promoter histone acylations
Nucleic Acids Research, 2021 Recent studies demonstrate that histones are subjected to a series of short-chain fatty acid modifications that is known as histone acylations. However, the enzymes responsible for histone acylations in vivo are not well characterized.
Yanhui Xiao +14 more
semanticscholar +1 more source
Molecules, 2022 Chlorothricin (CHL) belongs to a spirotetronate antibiotic family produced by Streptomyces antibioticus that inhibits pyruvate carboxylase and malate dehydrogenase.
Asad Ullah Saeed +3 more
doaj +1 more source
Acyltransferases in Bacteria [PDF]
Microbiology and Molecular Biology Reviews, 2013 SUMMARY Long-chain-length hydrophobic acyl residues play a vital role in a multitude of essential biological structures and processes. They build the inner hydrophobic layers of biological membranes, are converted to intracellular storage compounds, and are used to modify protein properties or function as membrane anchors, to name only a few ...
Alexander Steinbüchel +2 more
openaire +3 more sources
The zDHHC family of S-acyltransferases [PDF]
Biochemical Society Transactions, 2015 The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated proteins), defining the mechanisms of ...
Lemonidis, Kimon +7 more
openaire +4 more sources
Frontiers in Microbiology, 2021 In this issue we demonstrated that the phospholipid content of Streptomyces lividans varies greatly with Pi availability being was much lower in Pi limitation than in Pi proficiency whereas that of Streptomyces coelicolor varied little with Pi ...
Clara Lejeune +7 more
doaj +1 more source