Cholesterol esterification inhibition and imatinib treatment synergistically inhibit growth of BCR-ABL mutation-independent resistant chronic myelogenous leukemia [PDF]
, 2017 Since the advent of tyrosine kinase inhibitors (TKIs) such as imatinib, nilotinib, and dasatinib, chronic myelogenous leukemia (CML) prognosis has improved greatly. However, ~30-40% of patients develop resistance to imatinib therapy.
Bandyopadhyay, Shovik +6 more
core +7 more sources
The cholesterol-raising diterpenes from coffee beans increase serum lipid transfer protein activity levels in humans [PDF]
, 1997 Cafestol and kahweol–diterpenes present in unfiltered coffee— strongly raise serum VLDL and LDL cholesterol and slightly reduce HDL cholesterol in humans. The mechanism of action is unknown.
Gent, T. van +6 more
core +3 more sources
Acyltransferases in Protease’s Clothing [PDF]
The Plant Cell, 2000 One of the most intriguing questions in plant secondary metabolism concerns the evolution of the genes required for the rapid diversification of plant chemistry. In particular, the mechanisms are beginning to be understood by which evolution recruits primary and intermediary metabolism genes ...
openaire +3 more sources
Pretransplant assessment of human liver grafts by plasma lecithin: cholesterol acyltransferase (LCAT) activity in multiple organ donors. [PDF]
, 1992 In spite of the improved outcome of orthotopic liver transplantation (OLTx), primary graft nonfunction remains one of the life-threatening problems following OLTx.
A Lanir +25 more
core +1 more source
Frontiers in Microbiology, 2017 In rhizobium strains, the lipid A is modified by the addition of a very long-chain fatty acid (VLCFA) shown to play an important role in rigidification of the outer membrane, thereby facilitating their dual life cycle, outside and inside the plant.
Nicolas Busset +10 more
doaj +1 more source
mBio, 2021 To maintain optimal membrane dynamics, cells from all domains of life must acclimate to various environmental signals in a process referred to as homeoviscous adaptation.
Carmen M. Herrera +2 more
doaj +1 more source
Nature Communications, 2018 Lipid droplet (LD) accumulation is a now well-recognised hallmark of cancer. However, the significance of LD accumulation in colorectal cancer (CRC) biology is incompletely understood under chemotherapeutic conditions.
A. Cotte +11 more
semanticscholar +1 more source
Production of human recombinant proapolipoprotein A-I in Escherichia coli: purification and biochemical characterization [PDF]
, 1989 A human liver cDNA library was used to isolate a clone coding for apolipoprotein A-I (Apo A-I). The clone carries the sequence for the prepeptide (18 amino acids), the propeptide (6 amino acids), and the mature protein (243 amino acids).
Bollen, A. +12 more
core +1 more source
Methylation of the Gpat2 promoter regulates transient expression during mouse spermatogenesis [PDF]
, 2015 Spermatogenesis is a highly regulated process that involves both mitotic and meiotic divisions, as well as cellular differentiation to yield mature spermatozoa from undifferentiated germinal stem cells.
Cattaneo, Elizabeth Renee +6 more
core +2 more sources
Deficient Cholesterol Esterification in Plasma of apoc2 Knockout Zebrafish and Familial Chylomicronemia Patients. [PDF]
, 2017 Hypertriglyceridemia is an independent risk factor for cardiovascular disease. Apolipoprotein C-II (APOC2) is an obligatory cofactor for lipoprotein lipase (LPL), the major enzyme catalyzing plasma triglyceride hydrolysis.
Gaudet, Daniel +2 more
core +1 more source