Results 31 to 40 of about 72,098 (338)

Structural Basis for the Acyltransferase Activity of Lecithin:Retinol Acyltransferase-like Proteins [PDF]

Journal of Biological Chemistry, 2012
Lecithin:retinol acyltransferase-like proteins, also referred to as HRAS-like tumor suppressors, comprise a vertebrate subfamily of papain-like or NlpC/P60 thiol proteases that function as phospholipid-metabolizing enzymes. HRAS-like tumor suppressor 3, a representative member of this group, plays a key role in regulating triglyceride accumulation and ...
Marcin, Golczak, Philip D, Kiser, Avery E, Sears, David T, Lodowski, William S, Blaner, Krzysztof, Palczewski   +5 more
openaire   +2 more sources

Acylation of monolysocardiolipin in rat heart

Journal of Lipid Research, 1999
Cardiolipin is a major mitochondrial membrane glycerophospholipid in the mammalian heart. In this study, the ability of the isolated intact rat heart to remodel cardiolipin and the mitochondrial enzyme activities that reacylate monolysocardiolipin to ...
Brian J. Ma, William A. Taylor, Vernon W. Dolinsky, Grant M. Hatch   +3 more
doaj   +1 more source

Acyltransferases in Protease’s Clothing [PDF]

The Plant Cell, 2000
One of the most intriguing questions in plant secondary metabolism concerns the evolution of the genes required for the rapid diversification of plant chemistry. In particular, the mechanisms are beginning to be understood by which evolution recruits primary and intermediary metabolism genes ...
openaire   +2 more sources

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

The Structure and Function of Acylglycerophosphate Acyltransferase 4/ Lysophosphatidic Acid Acyltransferase Delta (AGPAT4/LPAATδ)

Frontiers in Cell and Developmental Biology, 2019
Lipid-modifying enzymes serve crucial roles in cellular processes such as signal transduction (producing lipid-derived second messengers), intracellular membrane transport (facilitating membrane remodeling needed for membrane fusion/fission), and protein
Mikhail A. Zhukovsky, Angela Filograna, Alberto Luini, Daniela Corda, Carmen Valente   +4 more
doaj   +1 more source

Automated structure prediction of trans-acyltransferase polyketide synthase products

Nature Chemical Biology, 2019
Bacterial trans-acyltransferase polyketide synthases (trans-AT PKSs) are among the most complex known enzymes from secondary metabolism and are responsible for the biosynthesis of highly diverse bioactive polyketides.
Eric J. N. Helfrich, Reiko Ueoka, A. Dolev, M. Rust, Roy A. Meoded, Agneya Bhushan, Gianmaria Califano, R. Costa, M. Gugger, C. Steinbeck, P. Moreno, J. Piel   +11 more
semanticscholar   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Evolutionary Developments in Plant Specialized Metabolism, Exemplified by Two Transferase Families

Frontiers in Plant Science, 2019
Plant specialized metabolism emerged from the land colonization by ancient plants, becoming diversified along with plant evolution. To date, more than 1 million metabolites have been predicted to exist in the plant kingdom, and their metabolic processes ...
Hiroaki Kusano, Hao Li, Hiroshi Minami, Yoshihiro Kato, Homare Tabata, Kazufumi Yazaki   +5 more
doaj   +1 more source

Genome-Wide Analysis of Serine Carboxypeptidase-Like Acyltransferase Gene Family for Evolution and Characterization of Enzymes Involved in the Biosynthesis of Galloylated Catechins in the Tea Plant (Camellia sinensis)

Frontiers in Plant Science, 2020
Tea (Camellia sinensis L.) leaves synthesize and concentrate a vast array of galloylated catechins (e.g., EGCG and ECG) and non-galloylated catechins (e.g., EGC, catechin, and epicatechin), together constituting 8%–24% of the dry leaf mass.
Muhammad Zulfiqar Ahmad, Penghui Li, Guangbiao She, Enhua Xia, Vagner A. Benedito, Xiao Chun Wan, Jian Zhao   +6 more
doaj   +1 more source

Targeting diacylglycerol acyltransferase 2 for the treatment of nonalcoholic steatohepatitis

Science Translational Medicine, 2019
Inhibition of DGAT2 reduces steatosis, inflammation, and fibrosis in rodent models of NASH and reduces liver fat in clinical testing. A pill a day keeps liver fat away Nonalcoholic fatty liver diseases can progress to liver failure but currently lack ...
N. Amin, S. Carvajal-Gonzalez, Julie J. Purkal, Tong Zhu, Collin Crowley, Sylvie Perez, Kristin Chidsey, Albert M. Kim, B. Goodwin   +8 more
semanticscholar   +1 more source