Results 201 to 210 of about 24,285 (335)

The pathogenesis of hepatic steatosis in MASLD: a lipid droplet perspective. [PDF]

J Clin Invest
Krahmer N, Walther TC, Farese RV.
europepmc   +1 more source

Gasdermins: multifunctional effectors of membrane permeabilization across cellular compartments

The FEBS Journal, EarlyView.
Gasdermins (GSDMs) are pore‐forming proteins best known for driving pyroptosis through plasma membrane (PM) permeabilization. Beyond triggering inflammatory cell death, GSDMs can also associate with organelle membranes, including mitochondria, lysosomes, ER, and nucleus, where they modulate membrane integrity and cellular signaling.
Eleonora Margheritis, Nadine Gehle, Katia Cosentino   +2 more
wiley   +1 more source

Role of novel protein acylation modifications in sepsis. [PDF]

Front Immunol
Wang J, He A, Song L, Jiang W, Xu L, Zheng R, Yu J.   +6 more
europepmc   +1 more source

Biostimulants in plant brassinosteroid hormone receptor BRI1 activation—a new system to evaluate activation capacity

The FEBS Journal, EarlyView.
A novel assay evaluates plant biostimulants targeting the brassinosteroid receptor BRI1, a central component in plant growth and development. By expressing BRI1 in fission yeast, functional activation by brassinolide (BL) was enabled. Transcriptomic profiling identified BL‐responsive genes, leading to a GFP‐based reporter system. This platform offers a
Maribel Marquina, Montserrat Ricart‐Fort, Rocío Díaz‐Parra, Sandra López‐Avilés, Tula Yance, Pablo Quirós, Elena Contreras, Ignasi Salaet, Sergio Atares, Rosa Aligué   +9 more
wiley   +1 more source

Integrated metabolomic and transcriptomic analysis of <i>Pogostemon cablin</i> shed new light on the complete biosynthesis pathway of pogostone. [PDF]

Front Plant Sci
Wang S, Zeng Z, Zhang Q, Liu W, Liu Q, Xie C, Bei J, Chen B, Zhang A.   +8 more
europepmc   +1 more source

Transglutaminase‐mediated cytokeratin modifications implicated in bile‐acid‐induced hepatocyte death

The FEBS Journal, EarlyView.
Cholestasis and bile‐acid exposure enhance expression and activity of protein crosslinking enzymes TG1 and TG2 in hepatocytes. Substrate proteins were identified by mass spectrometry using biotin‐labeled peptides (pepK5/pepT26) or amine donor (biotinylated pentylamine; BPA). Crosslinking‐induced aggregation and fragmentation of keratin 18 and 8 (K18/K8)
Hideki Tatsukawa, Haruka Nakagawa, Chin Mun Yee, Keiko Kuwata, Kiyotaka Hitomi   +4 more
wiley   +1 more source

Redox mechanism of glycerophospholipids and relevant targeted therapy in ferroptosis. [PDF]

Cell Death Discov
Chang S, Zhang M, Liu C, Li M, Lou Y, Tan H.   +5 more
europepmc   +1 more source

The Subgingival Host–Microbial Landscape in Mothers With Periodontitis and Their At‐Risk Offspring

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To evaluate the subgingival proteome and microbiome of mothers with periodontitis and their offspring, thereby assessing signatures of periodontal diseases. Methods Forty participants in four groups were included: mothers with periodontitis and their offspring, as well as periodontally healthy mothers and their offspring.
Hélvis E. S. Paz, Camila S. Stolf, Kai Bao, Mabelle F. Monteiro, Lucas M. Carvalho, Angelika Silbereisen, Georgios N. Belibasakis, Renato C. V. Casarin, Nagihan Bostanci   +8 more
wiley   +1 more source

Identification and functional characterization of BAHD acyltransferases associated with anthocyanin acylation in blueberry. [PDF]

Hortic Res
Mengist MF, Abid MA, Grace MH, Seth R, Bassil N, Kay CD, Dare AP, Chagné D, Espley RV, Neilson A, Lila MA, Ferruzzi M, Iorizzo M.   +12 more
europepmc   +1 more source

Ultrastructural expansion microscopy reveals unexpected levels of glycosome heterogeneity in African trypanosomes

Journal of Microscopy, EarlyView.
Abstract Kinetoplastid parasites include several species. Trypanosoma brucei causes African sleeping sickness in humans and a wasting disease nagana in livestock. Trypanosoma cruzi is the causative agent of Chagas disease and Leishmania species cause leishmaniasis, which can present with visceral, cutaneous, or mucocutaneous symptoms.
Heidi Anderson, Rhonda Reigers Powell, Meredith Teilhet Morris   +2 more
wiley   +1 more source