Results 211 to 220 of about 2,414,633 (297)

Data‐driven thresholds for standardized classification of severe Alzheimer's disease neuropathology using digital neuropathology

Brain Pathology, EarlyView.
We generated digital pathologic algorithms (AI‐based modules that can be freely shared) to: optimize the sampling (ROI) for diagnosis of ADNC‐related tau pathology; compare/transition between Aperio and HALO platforms; and rationalize severe Braak NFT staging, so that all Braak‐VI cases had dementia, and all Braak‐V cases had MCI or dementia.
Ryan K. Shahidehpour, Allison M. Neltner, Mitchell A. Klusty, Cole Corbett, Angelique D. Gonzalez, David A. Gutman, David W. Fardo, Adam D. Bachstetter, Cody Bumgardner, Margaret E. Flanagan, Peter T. Nelson   +10 more
wiley   +1 more source

Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition. [PDF]

Immunity
Navarro Negredo P, You J, Hauptschein M, Schroer AB, Richard DJ, Abhiraman GC, Tsai AP, Sun ED, Notarangelo G, Ramirez-Matias J, Zhou OY, Buckley MT, Malacon KE, Xu L, Sucharov J, Lopez ER, Picton L, Wyss-Coray T, Saxton RA, Fernandes RA, Villeda SA, Garcia KC, Brunet A.   +22 more
europepmc   +1 more source

The discovery and development of ensifentrine: A novel inhaled dual PDE3/4 inhibitor having ‘bifunctional’ bronchodilator and anti‐inflammatory activity

British Journal of Pharmacology, EarlyView.
Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley   +1 more source

Molecular de-extinction looks to the past to find the molecules of the future. [PDF]

Proc Natl Acad Sci U S A
Adam D.
europepmc   +1 more source

Changes in gastrointestinal motility and gut hormone secretion after Roux‐en‐Y gastric bypass and sleeve gastrectomy for individuals with severe obesity

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Background Bariatric surgery is very effective in long‐term weight management. The present study was undertaken to investigate the short‐term effects of sleeve gastrectomy (SG) and of Roux‐en‐Y gastric bypass (RYGB) on (a) gastrointestinal (GI) motility, that is gastric emptying and oro‐cecal transit time and (b) secretion of regulatory gut ...
Jennifer A. Wilbrink, Mark van Avesaat, Simon W. Nienhuijs, Arnold Stronkhorst, Ad A. M. Masclee   +4 more
wiley   +1 more source

Immunometabolic Modulation in Obese Asthma: How GLP-1 Receptor Agonists Could Influence Systemic and Pulmonary Immune Phenotypes. [PDF]

Pulm Ther
O'Brien H, Byrne AJ, Franciosi AN, Butler MW.   +3 more
europepmc   +1 more source

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source

Assessing the effectiveness of Sri Lankan marine protected areas: Challenges and recommendations

Conservation Science and Practice, EarlyView.
We evaluated the biodiversity conservation effectiveness of 32 zones of Sri Lankan marine protected areas (MPA) and found that most are currently insufficiently protected. Threats to MPAs were not uniform, with harmful dredging/dumping, anchoring, fishing, and non‐extractive activities identified as major pressures affecting different sets of MPAs.
Barbora Winterová, Chanaka Sooriyabandara, Jeffrey C. Nekola, Terney Pradeep Kumara   +3 more
wiley   +1 more source

Associations of Host Genetics and Plasma Proteomics with Incident Age-Related Macular Degeneration in Persons with AIDS. [PDF]

Ophthalmol Sci
Hunt PW, Sezgin E, Olshen AB, Murad N, Ambayec GC, Schneider MF, Jabs DA.   +6 more
europepmc   +1 more source

Speech, language, social communication, and communication assessments in Rett syndrome: A systematic review

Developmental Medicine &Child Neurology, EarlyView.
This systematic overview highlights communication impairment as a defining feature of Rett syndrome, with expressive language consistently affected more severely than receptive language and social ability. Across the literature, most studies rely on caregiver‐reported measures, with relatively few employing direct or objective measurements of speech ...
Lucas N. Raniolo, Ruth O. Braden, Jana von Hehn, John Christodoulou, David N. Lieberman, David J. Amor, Adam P. Vogel   +6 more
wiley   +1 more source