Results 131 to 140 of about 11,949 (172)

When proteases reshape barriers: Basement membrane remodelling in development, wound healing and tumour progression. [PDF]

FEBS J
Legendre C, Dayan G, Rousselle P.
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ADAMTS‐4 in central nervous system pathologies

Journal of Neuroscience Research, 2017
AbstractADAMTS‐4 (a disintegrin and metalloproteinase with thrombospondin motifs type 4) is a metalloproteinase specialized in the degradation of chondroitin sulfate proteoglycans, contributing to cartilage breakdown during arthritis. In this review, we first focus on the modifications of ADAMTS‐4 expression during CNS physiological and pathological ...
Sighild, Lemarchant, Sara, Wojciechowski, Denis, Vivien, Jari, Koistinaho   +3 more
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A microplate assay for the screening of ADAMTS-4 inhibitors

Matrix Biology, 2006
Aggrecanase plays a major role in cartilage proteoglycan degradation in rheumatic diseases such as osteoarthritis and rheumatoid arthritis. The search of new inhibitors of aggrecanase activity necessitates a robust assays in order to be able to screen large numbers of compounds.
Marie, Thomas, Massimo, Sabatini, Fabrice, Bensaude, Benoit, Mignard, Jean-Claude, Ortuno, Isabelle, Caron, Jean A, Boutin, Gilles, Ferry   +7 more
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ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis

Journal of Cellular Biochemistry, 2011
Osteoarthritis (OA) is a progressive disease of the joints characterized by degradation of articular cartilage. Although disease initiation may be multi-factorial, the cartilage destruction appears to be a result of uncontrolled proteolytic extracellular matrix destruction.
Priyanka, Verma, Krishna, Dalal
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Characterization of and osteoarthritis susceptibility in ADAMTS‐4–knockout mice

Arthritis & Rheumatism, 2004
AbstractObjectiveTo determine the importance of the enzymatic activity of ADAMTS‐4 in normal growth and development and to evaluate the role of ADAMTS‐4 in the progression of osteoarthritis (OA).MethodsWe generated catalytic domain–deleted ADAMTS‐4–transgenic mice and performed extensive gross and histologic analyses of various organs.
Sonya S, Glasson, Roger, Askew, Barbara, Sheppard, Brenda A, Carito, Tracey, Blanchet, Hak-Ling, Ma, Carl R, Flannery, Kim, Kanki, Eunice, Wang, Diane, Peluso, Zhiyong, Yang, Manas K, Majumdar, Elisabeth A, Morris   +12 more
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Aggrecanase-1 (ADAMTS-4) interacts with α1-antitrypsin

Biochimica et Biophysica Acta (BBA) - General Subjects, 2005
In degradative articular diseases such as rheumatoid arthritis and osteoarthritis, loss of the extracellular matrix occurs, resulting in the destruction of joint cartilage. Proteolysis of aggrecan is one of the early events that leads to breakdown of the extracellular matrix.
Koji, Yoshida, Yasuyuki, Suzuki, Akio, Saito, Kanji, Fukuda, Chiaki, Hamanishi, Hiroshi, Munakata   +5 more
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ADAMTS-4 and ADAMTS-5

2006
Osteoarthritis (OA) is characterized by articular cartilage erosion as a consequence of proteolytic cleavage of its two major functional macromolecules, type II collagen and aggrecan. Aggrecan degradation in OA and rheumatoid arthritis is attributed to cleavage at the Glu373-Ala374 bond by the aggrecanases.
Anne-Marie Malfait, Micky Tortorella, Elizabeth Arner   +2 more
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