Results 131 to 140 of about 11,544 (171)

Senescence-associated secretory phenotype: the "pathogenic" factor driving orthopedic degenerative diseases and its regulation. [PDF]

Front Aging
Ren J, Wang X, Zhou X, Fan X.
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Recombinant ADAMTS‑1 promotes muscle regeneration accompanied by downregulation of Notch signaling. [PDF]

Int J Mol Med
Kim JH, Lee SH, Kim SY, Kim JW, Jeong JS, Chung EH, Lee SH, Kim CY, Choi BK, Ko JW, Kim TW.   +10 more
europepmc   +1 more source

Diabetes-Related Metabolic Osteoarthritis: Advanced Glycation-Collagen Axis, Cartilage Stiffening, and Biomaterials-Based Therapeutic Strategies. [PDF]

Int J Nanomedicine
Li J, Cao B, Yu S, Li C, Xue M, Xie Q, Luo C, Duan C, Li Z, Jin C.   +9 more
europepmc   +1 more source

Effects of the space environment on articular cartilage homeostasis: a review. [PDF]

NPJ Microgravity
Ren Z, Huang H, Wang J.
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Targeting CCNB1 Repressed Cartilage Degradation Induced by Inflammation Through NF-κB Pathway in Osteoarthritis. [PDF]

J Histochem Cytochem
Li H, Qiao Y, Ding M, Liu Y.
europepmc   +1 more source

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ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis

Journal of Cellular Biochemistry, 2011
Osteoarthritis (OA) is a progressive disease of the joints characterized by degradation of articular cartilage. Although disease initiation may be multi-factorial, the cartilage destruction appears to be a result of uncontrolled proteolytic extracellular matrix destruction.
Priyanka, Verma, Krishna, Dalal
exaly   +3 more sources

ADAMTS‐4 in central nervous system pathologies

Journal of Neuroscience Research, 2017
AbstractADAMTS‐4 (a disintegrin and metalloproteinase with thrombospondin motifs type 4) is a metalloproteinase specialized in the degradation of chondroitin sulfate proteoglycans, contributing to cartilage breakdown during arthritis. In this review, we first focus on the modifications of ADAMTS‐4 expression during CNS physiological and pathological ...
Sighild, Lemarchant, Sara, Wojciechowski, Denis, Vivien, Jari, Koistinaho   +3 more
openaire   +2 more sources

A microplate assay for the screening of ADAMTS-4 inhibitors

Matrix Biology, 2006
Aggrecanase plays a major role in cartilage proteoglycan degradation in rheumatic diseases such as osteoarthritis and rheumatoid arthritis. The search of new inhibitors of aggrecanase activity necessitates a robust assays in order to be able to screen large numbers of compounds.
Marie, Thomas, Massimo, Sabatini, Fabrice, Bensaude, Benoit, Mignard, Jean-Claude, Ortuno, Isabelle, Caron, Jean A, Boutin, Gilles, Ferry   +7 more
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Characterization of and osteoarthritis susceptibility in ADAMTS‐4–knockout mice

Arthritis & Rheumatism, 2004
AbstractObjectiveTo determine the importance of the enzymatic activity of ADAMTS‐4 in normal growth and development and to evaluate the role of ADAMTS‐4 in the progression of osteoarthritis (OA).MethodsWe generated catalytic domain–deleted ADAMTS‐4–transgenic mice and performed extensive gross and histologic analyses of various organs.
Sonya S, Glasson, Roger, Askew, Barbara, Sheppard, Brenda A, Carito, Tracey, Blanchet, Hak-Ling, Ma, Carl R, Flannery, Kim, Kanki, Eunice, Wang, Diane, Peluso, Zhiyong, Yang, Manas K, Majumdar, Elisabeth A, Morris   +12 more
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Aggrecanase-1 (ADAMTS-4) interacts with α1-antitrypsin

Biochimica et Biophysica Acta (BBA) - General Subjects, 2005
In degradative articular diseases such as rheumatoid arthritis and osteoarthritis, loss of the extracellular matrix occurs, resulting in the destruction of joint cartilage. Proteolysis of aggrecan is one of the early events that leads to breakdown of the extracellular matrix.
Koji, Yoshida, Yasuyuki, Suzuki, Akio, Saito, Kanji, Fukuda, Chiaki, Hamanishi, Hiroshi, Munakata   +5 more
openaire   +2 more sources