Results 141 to 150 of about 11,544 (171)

ADAMTS-4 and ADAMTS-5

2006
Osteoarthritis (OA) is characterized by articular cartilage erosion as a consequence of proteolytic cleavage of its two major functional macromolecules, type II collagen and aggrecan. Aggrecan degradation in OA and rheumatoid arthritis is attributed to cleavage at the Glu373-Ala374 bond by the aggrecanases.
Anne-Marie Malfait, Micky Tortorella, Elizabeth Arner   +2 more
openaire   +1 more source

Regulation of the human ADAMTS-4 promoter by transcription factors and cytokines

Biochemical and Biophysical Research Communications, 2006
ADAMTS-4 (aggrecanase-1) is a metalloprotease that plays a role in aggrecan degradation in the cartilage extracellular matrix. In order to understand the regulation of ADAMTS-4 gene expression we have cloned and characterized a functional 4.5kb human ADAMTS-4 promoter.
Kannan, Thirunavukkarasu, Yong, Pei, Terry L, Moore, He, Wang, Xiao-Peng, Yu, Andrew G, Geiser, Srinivasan, Chandrasekhar   +6 more
openaire   +2 more sources

ADAMTS‐4 in oligodendrocytes contributes to myelination with an impact on motor function

Glia, 2017
AbstractMyelination is a late developmental process regulated by a set of inhibitory and stimulatory factors, including extracellular matrix components. Accordingly, chondroitin sulfate proteoglycans (CSPGs) act as negative regulators of myelination processes.
Pruvost, Mathilde, Lépine, Matthieu, Leonetti, Camille, Etard, Olivier, Naveau, Mikaël, Agin, Véronique, Docagne, Fabian, Maubert, Eric, Ali, Carine, Emery, Evelyne, Vivien, Denis   +10 more
openaire   +3 more sources

ADAMTS-4 (aggrecanase-1): N-Terminal activation mechanisms

Archives of Biochemistry and Biophysics, 2005
ADAMTS-4 (aggrecanase 1) is synthesized as a latent precursor protein that may require activation through removal of its prodomain before it can exert catalytic activity. We examined various proteinases as well as auto-activation under a wide range of conditions for removal of the prodomain and induction of enzymatic activity.
Micky D, Tortorella, Elizabeth C, Arner, Robert, Hills, Jennifer, Gormley, Kam, Fok, Lyle, Pegg, Grace, Munie, Anne-Marie, Malfait   +7 more
openaire   +2 more sources

Chrysin downregulates the expression of ADAMTS-4 in foam cells

Molecular Biology Reports
Chrysin, a polyphenolic compound, possesses antioxidant and anti-inflammatory properties. In this study, we investigated the effect of chrysin on the expression of A disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4), a protease enzyme involved in degrading extracellular matrix associated with atherosclerosis.We have studied the ...
S. S. Aswani, Sreelekshmi G. Jayan, Mithra S. Mohan, N. S. Aparna, P. T. Boban, K. Saja   +5 more
openaire   +2 more sources

CHANGES TO LEVELS OF CHONDROCYTE-ASSOCIATED ADAMTS-4 IN EARLY HUMAN OSTEOARTHRITIS

Orthopaedic Proceedings, 2023
Early changes within articular cartilage during human idiopathic osteoarthritis are poorly understood. However alterations to chondrocyte morphology occur with the development of fine cytoplasmic processes and cell clusters, potentially playing a role in cartilage degeneration.
A. Herren, A. Luczak, A. Amin, A. Hall
openaire   +1 more source

Anti‐inflammatory effects of ADAMTS‐4 in a mouse model of ischemic stroke

Glia, 2016
ADAMTS‐4 (a disintegrin and metalloproteinase with thrombospondin motifs type 4) is a metalloprotease capable to degrade chondroitin sulfate proteoglycans leading to cartilage destruction during arthritis or to neuroplasticity during spinal cord injury (SCI).
Sighild, Lemarchant, Hiramani, Dunghana, Yuriy, Pomeshchik, Henri, Leinonen, Natalia, Kolosowska, Paula, Korhonen, Katja M, Kanninen, Teresa, García-Berrocoso, Joan, Montaner, Tarja, Malm, Jari, Koistinaho   +10 more
openaire   +2 more sources

Pharmacophore development and screening for discovery of potential inhibitors of ADAMTS-4 for osteoarthritis therapy

Journal of Molecular Modeling, 2016
In the development of osteoarthritis, aggrecan degrades prior to cartilage destruction. Aggrecanase-1 (ADAMTS-4) is considered to be the major enzyme responsible for cleaving the Glu373-Ala374 bond in the interglobular domain of aggrecan in humans. Therefore, inhibitors of ADAMTS-4 have therapeutic potential in the treatment of osteoarthritis.
Priyanka, Verma, Krishna, Dalal, Madhu, Chopra   +2 more
openaire   +2 more sources

ADAMTS‐4 and ADAMTS‐5 sequestration and activity in chondrocyte‐agarose cultures

International Journal of Experimental Pathology, 2004
Introduction  A primary event in the destruction of cartilage in arthritic diseases is the loss of aggrecan from the extracellular matrix of articular cartilage. During aggrecan breakdown, cleavage sites are utilized, which reside within the IGD of the aggrecan core protein.
Alison J. Rees, Chris B. Little, Bruce Caterson, Clare E. Hughes   +3 more
openaire   +1 more source

Characterisation of ADAMTS-4 endocytosis by chondrosarcoma cells and chondrocytes

2009
Aggrecan is one of the most abundant components of the articular cartilage matrix and its degradation by aggrecanases is considered to be a key early event in the development of osteoarthritis. This study investigates whether the extracellular level of ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin type 1 motifs-4), one of the most ...
openaire   +2 more sources