Results 21 to 30 of about 20,502 (253)

Role of ADAMTS13, VWF and F8 genes in deep vein thrombosis.

PLoS ONE, 2021
BackgroundWe previously described the association between rare ADAMTS13 single nucleotide variants (SNVs) and deep vein thrombosis (DVT). Moreover, DVT patients with at least one rare ADAMTS13 SNV had a lower ADAMTS13 activity than non-carriers.AimsTo ...
Maria Teresa Pagliari, Andrea Cairo, Marco Boscarino, Ilaria Mancini, Emanuela Pappalardo, Paolo Bucciarelli, Ida Martinelli, Frits R Rosendaal, Flora Peyvandi   +8 more
doaj   +2 more sources

Associations between the von Willebrand Factor—ADAMTS13 Axis, Complement Activation, and COVID-19 Severity and Mortality

Thrombosis and Haemostasis, 2022
Background  Endothelial and complement activation were both associated with immunothrombosis, a key determinant of COVID-19 severity, but their interrelation has not yet been investigated.
G. Sinkovits, M. Réti, V. Müller, Z. Iványi, J. Gal, L. Gopcsa, P. Reményi, B. Szathmáry, B. Lakatos, J. Szlávik, I. Bobek, Z. Prohászka, Z. Förhécz, B. Mező, D. Csuka, L. Hurler, E. Kajdácsi, L. Cervenak, P. Kiszel, T. Masszi, I. Vályi-Nagy, Z. Prohászka   +21 more
semanticscholar   +1 more source

The Impact of Age and BMI on the VWF/ADAMTS13 Axis and Simultaneous Thrombin and Plasmin Generation in Hospitalized COVID-19 Patients

Frontiers in Medicine, 2022
Aging and obesity independently contribute toward an endothelial dysfunction that results in an imbalanced VWF to ADAMTS13 ratio. In addition, plasma thrombin and plasmin generation are elevated and reduced, respectively, with increasing age and also ...
Kiruphagaran Thangaraju, Upendra K. Katneni, I. Akpan, Kenichi A. Tanaka, Tiffany A. Thomas, Saini Setua, J. Reisz, F. Cendali, F. Gamboni, T. Nemkov, S. Kahn, Alexander Z. Wei, Jacob E. Valk, K. Hudson, D. Roh, C. Moriconi, J. Zimring, Angelo D’Alessandro, S. Spitalnik, R. Francis, P. Buehler   +20 more
semanticscholar   +1 more source

Phenotypic expression of ADAMTS13 in glomerular endothelial cells.

PLoS ONE, 2011
BackgroundADAMTS13 is the physiological von Willebrand factor (VWF)-cleaving protease. The aim of this study was to examine ADAMTS13 expression in kidneys from ADAMTS13 wild-type (Adamts13⁺/⁺) and deficient (Adamts13⁻/⁻) mice and to investigate the ...
Ramesh Tati, Ann-Charlotte Kristoffersson, Anne-Lie Ståhl, Matthias Mörgelin, David Motto, Simon Satchell, Peter Mathieson, Minola Manea-Hedström, Diana Karpman   +8 more
doaj   +1 more source

AFM Imaging Reveals Multiple Conformational States of ADAMTS13

Journal of Biological Engineering, 2019
Background ADAMTS13 (A disintegrin and metalloprotease with a thrombospondin type 1 motif 13) cleaves Von Willebrand factor (VWF) to regulate its size, thereby preventing aberrant platelet aggregation and thrombus. Deficiency of ADAMTS13 caused by either
Shanshan Yu, Wang Liu, Jinhua Fang, Xiaozhong Shi, Jianhua Wu, Ying Fang, Jiangguo Lin   +6 more
doaj   +1 more source

Levels of von Willebrand factor antigen and von Willebrand factor cleaving protease (ADAMTS13) activity predict clinical events in chronic heart failure. [PDF]

, 2009
Decreased activity of ADAMTS13, the von Willebrand factor (VWF) cleaving protease, was recently reported in cardiovascular diseases and in hepatic failure.
Borgulya, Gábor, Cervenak, László, Förhécz, Zsolt, Gombos, Tímea, Hársfalvi, Jolán, Jánoskuti, Lívia, Kunde, Jan, Makó, Veronika, Papassotiriou, Jana, Pozsonyi, Zoltán, Prohászka, Zoltán   +10 more
core   +1 more source

Bethesda Assay for Detecting Inhibitory Anti-ADAMTS13 Antibodies in Immune-Mediated Thrombotic Thrombocytopenic Purpura

TH Open, 2018
A diagnosis of thrombotic thrombocytopenic purpura (TTP) is confirmed by a severe deficiency (
Chiara Vendramin, Mari Thomas, John-Paul Westwood, Marie Scully   +3 more
doaj   +1 more source

Diagnosis of thrombotic thrombocytopenic purpura

Терапевтический архив, 2020
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disease, disease, characterised by microangiopathic hemolytic anaemia, consumption thrombocytopenia, and organ dysfunction.
G. M. Galstyan, E. E. Klebanova
doaj   +1 more source

How I treat thrombotic thrombocytopenic purpura and atypical haemolytic uraemic syndrome [PDF]

, 2014
Thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome (aHUS) are acute, rare life-threatening thrombotic microangiopathies that require rapid diagnosis and treatment.
Goodship, T, Scully, M
core   +1 more source

The class I scavenger receptor CD163 promotes internalization of ADAMTS13 by macrophages

Blood Advances, 2017
: Internalization of ADAMTS13 by macrophages may contribute to its clearance from the circulation. Here we investigated endocytic mechanisms that contribute to the uptake of ADAMTS13 by macrophages. Human monocyte-derived macrophages were used to monitor
Fabian C. Verbij, Nicoletta Sorvillo, Paul H.P. Kaijen, Johana Hrdinova, Ivan Peyron, Rob Fijnheer, Anja ten Brinke, Alexander B. Meijer, Floris P.J. van Alphen, Timo K. van den Berg, Jonas J.H. Graversen, Soren K. Moestrup, Jan Voorberg   +12 more
doaj   +1 more source