Results 21 to 30 of about 13,808 (210)
Rituximab induced pulmonary edema managed with extracorporeal life support [PDF]
, 2018 Though rare, rituximab has been reported to induce severe pulmonary edema. We describe the first report of ECLS utilization for this indication. A 31-year-old female with severe thrombotic thrombocytopenic purpura developed florid pulmonary edema after ...
Aguilar, Patrick +6 more
core +3 more sources
Conformational activation of ADAMTS13 [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance We show that a CUB–spacer domain interaction impedes exposure of the ADAMTS13 spacer functional exosite, preventing ADAMTS13 from interacting effectively with its complementary binding site in the VWF A2 domain. This CUB–spacer interaction is disrupted by interaction with the C-terminal domains of VWF, leading to conformational ...
South, Kieron +8 more
openaire +5 more sources
A rare case of renal thrombotic microangiopathy associated with Castleman’s disease [PDF]
, 2017 BACKGROUND: Castleman’s disease (CD) is an uncommon, heterogeneous lympho-proliferative disorder leading to high circulating levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF).
Chen, Ying Maggie +3 more
core +2 more sources
How I treat thrombotic thrombocytopenic purpura and atypical haemolytic uraemic syndrome [PDF]
, 2014 Thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome (aHUS) are acute, rare life-threatening thrombotic microangiopathies that require rapid diagnosis and treatment.
Goodship, T, Scully, M
core +1 more source
ADAMTS13 and Non-ADAMTS13 Biomarkers in Immune-Mediated Thrombotic Thrombocytopenic Purpura
Journal of Clinical Medicine, 2023 Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare medical emergency for which a correct and early diagnosis is essential. As a severe deficiency in A Disintegrin And Metalloproteinase with ThromboSpondin type 1 repeats, member 13 (ADAMTS13) is the underlying pathophysiology, diagnostic strategies require timely monitoring of ADAMTS13
Bonnez, Quintijn +2 more
openaire +3 more sources
Reduced ADAMTS13 levels in patients with acute and chronic cerebrovascular disease. [PDF]
PLoS ONE, 2017 Von Willebrand Factor (VWF) plays a major role in thrombosis and hemostasis and its thrombogenicity is controlled by ADAMTS13. Whereas increasing evidence shows a clear association between VWF levels and acute ischemic stroke, little is known about a ...
Frederik Denorme +7 more
doaj +1 more source
Genetic variants in ADAMTS13 as well as smoking are major determinants of plasma ADAMTS13 levels
Blood Advances, 2017 : The metalloprotease ADAMTS13 cleaves von Willebrand factor (VWF) in circulating blood, limiting the size of VWF multimers and regulating VWF activity. Abnormal regulation of VWF contributes to bleeding and to thrombotic disorders.
Qianyi Ma +9 more
doaj +1 more source
Association between ADAMTS13 deficiency and cardiovascular events in chronic hemodialysis patients
Scientific Reports, 2021 A mild decrease of ADAMTS13 (a disintegrin and metalloprotease with thrombospodin type 1 motif 13) could attribute to stroke and coronary heart disease in general population.
Shih-Yuan Hung +9 more
doaj +1 more source
Signalment risk factors for cutaneous and renal glomerular vasculopathy (Alabama rot) in dogs in the UK [PDF]
, 2018 Seasonal outbreaks of cutaneous and renal glomerular vasculopathy (CRGV) have been reported annually in UK dogs since 2012, yet the aetiology of the disease remains unknown. The objectives of this study were to explore whether any breeds had an increased
Cardwell, J M +5 more
core +2 more sources
Thrombosis Journal, 2017 Background The mechanisms behind residual platelet reactivity (RPR) despite aspirin treatment are not established. It has been shown that coronary artery disease (CAD) patients with high on-aspirin RPR have elevated levels of von Willebrand factor (vWF).
Ellen M. K. Warlo +3 more
doaj +1 more source