Results 41 to 50 of about 20,502 (253)

Predictive features of severe acquired ADAMTS13 deficiency in idiopathic thrombotic microangiopathies: the French TMA reference center experience. [PDF]

PLoS ONE, 2010
Severe ADAMTS13 deficiency occurs in 13% to 75% of thrombotic microangiopathies (TMA). In this context, the early identification of a severe, antibody-mediated, ADAMTS13 deficiency may allow to start targeted therapies such as B-lymphocytes-depleting ...
Paul Coppo, Michael Schwarzinger, Marc Buffet, Alain Wynckel, Karine Clabault, Claire Presne, Pascale Poullin, Sandrine Malot, Philippe Vanhille, Elie Azoulay, Lionel Galicier, Virginie Lemiale, Jean-Paul Mira, Christophe Ridel, Eric Rondeau, Jacques Pourrat, Stéphane Girault, Dominique Bordessoule, Samir Saheb, Michel Ramakers, Mohamed Hamidou, Jean-Paul Vernant, Bertrand Guidet, Martine Wolf, Agnès Veyradier, French Reference Center for Thrombotic Microangiopathies   +25 more
doaj   +1 more source

Increased plasma von Willebrand factor antigen levels but normal von Willebrand factor cleaving protease (ADAMTS13) activity in preeclampsia. [PDF]

, 2009
The activity of ADAMTS13, the von Willebrand factor (VWF) cleaving protease is low in several conditions, including HELLP (haemolysis, elevated liver enzymes, and low platelet count) syndrome.
Bõze, Tamás, Cervenak, László, Derzsy, Zoltán, Gombos, Tímea, Hársfalvi, Jolán, Makó, Veronika, Molvarec, Attila, Prohászka, Zoltán, Rigó, János, Udvardy, Miklós László   +9 more
core   +1 more source

Synonymous ADAMTS13 variants impact molecular characteristics and contribute to variability in active protein abundance

Blood Advances, 2022
Key Points ADAMTS13 sSNVs affect mRNA thermodynamic stability and may disturb mRNA-splicing sites. Synonymous variations may affect ADAMTS13 function and contribute to large variability in protein expression levels in healthy individuals.
Katarzyna I. Jankowska, Douglas Meyer, David Holcomb, Jacob Kames, N. Hamasaki-Katagiri, Upendra K. Katneni, R. Hunt, J. Ibla, C. Kimchi-Sarfaty   +8 more
semanticscholar   +1 more source

Association between ADAMTS13 deficiency and cardiovascular events in chronic hemodialysis patients

Scientific Reports, 2021
A mild decrease of ADAMTS13 (a disintegrin and metalloprotease with thrombospodin type 1 motif 13) could attribute to stroke and coronary heart disease in general population.
Shih-Yuan Hung, Tsun-Mei Lin, Hung-Hsiang Liou, Ching-Yang Chen, Wei-Ting Liao, Hsi-Hao Wang, Li-Chun Ho, Ching-Fang Wu, Yi-Che Lee, Min-Yu Chang   +9 more
doaj   +1 more source

Infection frequently triggers thrombotic microangiopathy in patients with preexisting risk factors : a single-institution experience [PDF]

, 2010
Thrombotic microangiopathies are rare conditions characterized by microangiopathic hemolytic anemia, microthrombi, and multiorgan insult. The disorders, which include hemolytic uremic syndrome and thrombotic thrombocytopenic purpura, are often acute and ...
Catlow, Jamie, Douglas, Kenneth W., Green, Rachel, Pollock, Kevin G.J., Young, David   +4 more
core   +1 more source

vWF/ADAMTS13 is associated with on-aspirin residual platelet reactivity and clinical outcome in patients with stable coronary artery disease

Thrombosis Journal, 2017
Background The mechanisms behind residual platelet reactivity (RPR) despite aspirin treatment are not established. It has been shown that coronary artery disease (CAD) patients with high on-aspirin RPR have elevated levels of von Willebrand factor (vWF).
Ellen M. K. Warlo, Alf-Åge R. Pettersen, Harald Arnesen, Ingebjørg Seljeflot   +3 more
doaj   +1 more source

Perinatal Gene Transfer to the Liver [PDF]

, 2011
The liver acts as a host to many functions hence raising the possibility that any one may be compromised by a single gene defect. Inherited or de novo mutations in these genes may result in relatively mild diseases or be so devastating that death within
Buckley, SM, Chan, JK, Howe, SJ, McKay, TR, Rahim, AA, Waddington, SN, Ward, NJ   +6 more
core   +1 more source

The ADAMTS13‐von Willebrand factor axis in COVID‐19 patients

Journal of Thrombosis and Haemostasis, 2020
Severe coronavirus disease 2019 (COVID‐19) is characterized by an increased risk of thromboembolic events, with evidence of microthrombosis in the lungs of deceased patients.
I. Mancini, L. Baronciani, A. Artoni, P. Colpani, Marina Biganzoli, G. Cozzi, C. Novembrino, Massimo Boscolo Anzoletti, Valentina de Zan, M. Pagliari, R. Gualtierotti, S. Aliberti, M. Panigada, G. Grasselli, F. Blasi, F. Peyvandi   +15 more
semanticscholar   +1 more source

Removal of the C-Terminal Domains of ADAMTS13 by Activated Coagulation Factor XI induces Platelet Adhesion on Endothelial Cells under Flow Conditions

Frontiers in Medicine, 2017
Platelet recruitment to sites of vascular injury is mediated by von Willebrand factor (VWF). The shear-induced unraveling of ultra-large VWF multimers causes the formation of a “stringlike” conformation, which rapidly recruits platelets from the ...
Kathleen S. Garland, Kathleen S. Garland, Stéphanie E. Reitsma, Stéphanie E. Reitsma, Toshiaki Shirai, Jevgenia Zilberman-Rudenko, Erik I. Tucker, Erik I. Tucker, David Gailani, András Gruber, András Gruber, Owen J. T. McCarty, Cristina Puy   +12 more
doaj   +1 more source

Signalment risk factors for cutaneous and renal glomerular vasculopathy (Alabama rot) in dogs in the UK [PDF]

, 2018
Seasonal outbreaks of cutaneous and renal glomerular vasculopathy (CRGV) have been reported annually in UK dogs since 2012, yet the aetiology of the disease remains unknown. The objectives of this study were to explore whether any breeds had an increased
Cardwell, J M, Holm, L P, Jepson, R E, O'Neill, D G, Stevens, K B, Walker, D J   +5 more
core   +2 more sources