Results 71 to 80 of about 13,808 (210)

Systemic antithrombotic effects of ADAMTS13 [PDF]

The Journal of Experimental Medicine, 2006
The metalloprotease ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type I repeats 13) cleaves highly adhesive large von Willebrand factor (VWF) multimers after their release from the endothelium. ADAMTS13 deficiency is linked to a life-threatening disorder, thrombotic thrombocytopenic purpura (TTP), characterized by platelet-rich ...
Chauhan, Anil K., Motto, David G., Lamb, Colin B., Bergmeier, Wolfgang, Dockal, Michael, Plaimauer, Barbara, Scheiflinger, Friedrich, Ginsburg, David, Wagner, Denisa D.   +8 more
openaire   +2 more sources

Dried plasma retains hemostatic function and thermal stability during Arctic military operations

Transfusion, EarlyView.
Abstract Background Dried plasma offers a practical alternative for remote damage control resuscitation, providing hemostatic support and volume replacement. The Arctic presents challenges that necessitate the need for blood‐based resuscitation to extend the “golden hour.” To address this, we evaluated the hemostatic and thermal stability of dried ...
Kanwal Singh, Aron A. Shoara, Henry T. Peng, Viktor Prifti, Katy Moes, Cerys McGuinness, Tristan Bonnici, Maria Shiu, Sushmaa Chandralekha Selvakumar, Peter Andrisani, Pierre‐Marc Dion, Damien Miller, Sebastian Vuong, Colin A. Kretz, Philip J. Wallace, Shawn G. Rhind, Wendy Sullivan‐Kwantes, Andrew N. Beckett   +17 more
wiley   +1 more source

Concomitant Immune‐Mediated Thrombotic Thrombocytopenic Purpura and Evans Syndrome With Multiple Cerebral Infarctions in an Elderly Patient

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT We report a rare case of concomitant immune thrombotic thrombocytopenic purpura (iTTP) and Evans syndrome, complicated by multiple cerebral infarctions. The patient presented with severe thrombocytopenia and hemolytic anemia, as well as a positive direct Coombs test. The initial diagnosis was Evans syndrome.
Shinichi Ogawa, Yangsu Kim, Takayoshi Ito   +2 more
wiley   +1 more source

Noonan Syndrome Presenting With Severe Transient Thrombocytopenia and Hemolytic Anemia in a Neonate With a Germline PTPN11 Pathogenic Variant

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT Noonan syndrome (NS) is a RASopathy that can have hematological presentations, most commonly NS‐related myeloproliferative disorder (NS/MPD) and juvenile myelomonocytic leukemia. Other neonatal hematologic presentations remain poorly defined.
Ariel Gershon, Tanvi Anandampillai, Elaine Suk‐Ying Goh, Caroline Malcolmson, Yiming Wang   +4 more
wiley   +1 more source

Predictive features of severe acquired ADAMTS13 deficiency in idiopathic thrombotic microangiopathies: the French TMA reference center experience.

PLoS ONE, 2010
Severe ADAMTS13 deficiency occurs in 13% to 75% of thrombotic microangiopathies (TMA). In this context, the early identification of a severe, antibody-mediated, ADAMTS13 deficiency may allow to start targeted therapies such as B-lymphocytes-depleting ...
Paul Coppo, Michael Schwarzinger, Marc Buffet, Alain Wynckel, Karine Clabault, Claire Presne, Pascale Poullin, Sandrine Malot, Philippe Vanhille, Elie Azoulay, Lionel Galicier, Virginie Lemiale, Jean-Paul Mira, Christophe Ridel, Eric Rondeau, Jacques Pourrat, Stéphane Girault, Dominique Bordessoule, Samir Saheb, Michel Ramakers, Mohamed Hamidou, Jean-Paul Vernant, Bertrand Guidet, Martine Wolf, Agnès Veyradier, French Reference Center for Thrombotic Microangiopathies   +25 more
doaj   +1 more source

Longitudinal assessments of plasma ADAMTS13 biomarkers predict recurrence of immune thrombotic thrombocytopenic purpura

Blood Advances, 2019
: Immune thrombotic thrombocytopenic purpura (iTTP) is primarily caused by immunoglobulin G (IgG)–type autoantibodies that bind and inhibit plasma ADAMTS13 activity and/or accelerate its clearance from circulation. Approximately 50% of patients with iTTP
Jingrui Sui, Wenjing Cao, Konstantine Halkidis, Mohammad S. Abdelgawwad, Nicole K. Kocher, Bryan Guillory, Lance A. Williams, Radhika Gangaraju, Marisa B. Marques, X. Long Zheng   +9 more
doaj   +1 more source

Real-world data of thrombotic microangiopathy management: The key role of ADAMTS13 activity and complement testing

Thrombosis Update, 2021
ADAMTS13 (A Disintegrin and Metalloprotease with ThromboSpondin type 1 motifs) activity is a key tool in differential diagnosis of thrombotic microangiopathies (TMAs).
Eleni Gavriilaki, Eudoxia-Evaggelia Koravou, Thomas Chatziconstantinou, Christina Kalpadaki, Nikoleta Printza, Maria Ximeri, Anna Christoforidou, George Karavalakis, Maria Kaliou, Vassiliki Kalaitzidou, Iliana Tassi, Maria Tzellou, Tasoula Touloumenidou, Apostolia Papalexandri, Maria Papathanasiou, Antonia Syrigou, Anna Kioumi, Maria Liga, Georgia Kaiafa, Alexandros Spyridonidis, Eleni Kapsali, Konstantinos Kollios, Eudokia Mandala, Efthymia Vlachaki, Panagiotis Tsirigotis, Eleni Papadaki, Chrysavgi Lalayanni, Ioanna Sakellari, Achilles Anagnostopoulos   +28 more
doaj   +1 more source

A case of refractory thrombotic thrombocytopenic purpura treated with plasmapheresis and rituximab [PDF]

, 2016
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disorder with no prevalence or incidence studies in sub-Saharan Africa. Acquired TTP has several causes, all of which lead to decreased activity of von Willebrand factor cleaving ...
Kirui, Nicholas, Sokwala, Ahmed
core   +4 more sources

Physical Fitness Is Negatively Associated With DNA Methylation‐Based Risk of Aging‐Related Diseases

Aging Cell, Volume 25, Issue 4, April 2026.
We found 33 significant associations between DNA methylation–based protein level estimates (EpiScores) and fitness traits in older adults. Then we found 51 associations between fitness traits and chronic age‐related diseases, enabling a workflow for evaluating patient‐level disease risk by using DNA methylation and fitness measurements.
Samiha Nasser, Johanna Keringer, Yaodong Gu, Istvan Boldogh, Xueqing Ba, Mitsuru Higuchi, Csaba Kerepesi, Zsolt Radak   +7 more
wiley   +1 more source

ADAMTS13 inhibits H2O2-induced human venous endothelial cell injury to attenuate deep-vein thrombosis by blocking the p38/ERK signaling pathway

Chinese Journal of Physiology, 2023
Deep vein thrombosis (DVT) is a common complication in hematologic malignancies and immunologic disorders. Endothelial cell injury and dysfunction comprise the critical contributor for the development of DVT.
Guangfeng Zheng, Qiang Zhang, Chuanyong Li, Weijian Fan, Zhichang Pan, Yuting Zhou, Yan Chen, Jianjie Rong   +7 more
doaj   +1 more source