Results 71 to 80 of about 12,902 (159)

Bleeding Complications in JAK2‐Variant Essential Thrombocythemia: A Revisit in 2025

eJHaem, Volume 6, Issue 4, August 2025.
ABSTRACT Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterised by sustained thrombocytosis. Paradoxically, bleeding complications remain an under‐recognised clinical challenge. Compared with CALR‐mutated patients, those harbouring the JAK2‐V617F variant appear more prone to haemorrhage.
Gerard Gurumurthy, Samantha Gurumurthy, Tim C. P. Somervaille, Anna Falanga, Jecko Thachil   +4 more
wiley   +1 more source

Efficacy of High‐Dose Intravenous Anakinra in Pediatric TAFRO Syndrome: Report of Two Cases and Literature Review

Pediatric Blood &Cancer, Volume 72, Issue 8, August 2025.
ABSTRACT TAFRO (thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly) syndrome is a rare, life‐threatening inflammatory condition linked to infections, neoplasms, and idiopathic multicentric Castleman disease. Interleukin (IL)‐6 inhibitors are the primary treatment, but refractory cases require alternatives. This
Serena Palmeri, Jacopo Ferro, Valentina Natoli, Caterina Matucci‐Cerinic, Riccardo Papa, Silvia Rosina, Stefania Sorrentino, Stefano Volpi, Valerio Gaetano Vellone, Marco Gattorno, Roberta Caorsi   +10 more
wiley   +1 more source

Concentration and Subclass Distribution of Anti-ADAMTS13 IgG Autoantibodies in Different Stages of Acquired Idiopathic Thrombotic Thrombocytopenic Purpura

Frontiers in Immunology, 2018
BackgroundThe acquired form of idiopathic thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease, in which the underlying deficiency of the ADAMTS13 protease is caused by autoantibodies, predominantly of the IgG isotype.
György Sinkovits, Ágnes Szilágyi, Péter Farkas, Dóra Inotai, Anikó Szilvási, Attila Tordai, Katalin Rázsó, Marienn Réti, Zoltán Prohászka   +8 more
doaj   +1 more source

Circulating Proteomics and Risk of Atrial Fibrillation: A Systematic Review of Cohort Studies

Journal of Cellular and Molecular Medicine, Volume 29, Issue 15, August 2025.
ABSTRACT Atrial fibrillation (AF) is a common arrhythmia associated with significant morbidity and adverse outcomes. High‐throughput proteomics offers a promising approach for identifying circulating biomarkers to improve AF risk stratification.
Luxiang Shang, Weilin Wang, Yiying Liu, Baopeng Tang, Yinglong Hou   +4 more
wiley   +1 more source

Performance related factors are the main determinants of the von Willebrand factor response to exhaustive physical exercise [PDF]

, 2014
Background: Physical stress triggers the endothelium to release von Willebrand Factor (VWF) from the Weibel Palade bodies. Since VWF is a risk factor for arterial thrombosis, it is of great interest to discover determinants of VWF response to physical ...
A Casonato, AM Keightley, AO Spiel, BC Creighton, CH Widberg, DD Wagner, DJ Pinsky, EM Bladbjerg, Frank W. G. Leebeek, G Lippi, G Lippi, G Rock, GY Lip, H Tanaka, I Martinelli, IM Lee, J Myers, J Ribeiro, J Stakiw, Janine E. van Loon, JB Hansen, JC Souto, JE Sadler, JE van Loon, JL Ribeiro, JP Giblin, JR Day, L Gallinaro, LA Sporn, M de Lange, M Small, MC van Schie, MD Delp, Michelle A. H. Sonneveld, MJ Hollestelle, Moniek P. M. de Maat, MP Reilly, MS El-Sayed, MS El-Sayed, N Hickson, NL Smith, NL Smith, O Wu, PH Whincup, PJ Harvey, RA Claus, RA Reiter, RG Wieberdink, S Kanaji, S Lethagen, Stephan F. E. Praet, T Mayadas, Toshiyuki Miyata, V Daidone, YY Zhang   +54 more
core   +4 more sources

Two causes of COVID‐19‐related myocardial injury‐associated cardiogenic shock: Myocarditis and microvascular thrombosis

ESC Heart Failure, Volume 12, Issue 2, Page 1514-1522, April 2025.
Takamasa Iwai, Hirohiko Aikawa, Yoshiaki Morita, Keiko Ohta‐Ogo, Teruo Noguchi   +4 more
wiley   +1 more source

Determination of ADAMTS13 and Its Clinical Significance for ADAMTS13 Supplementation Therapy to Improve the Survival of Patients with Decompensated Liver Cirrhosis

International Journal of Hepatology, 2011
The liver plays a central role in hemostasis by synthesizing clotting factors, coagulation inhibitors, and fibrinolytic proteins. Liver cirrhosis (LC), therefore, impacts on both primary and secondary hemostatic mechanisms.
Masahito Uemura, Yoshihiro Fujimura, Saiho Ko, Masanori Matsumoto, Yoshiyuki Nakajima, Hiroshi Fukui   +5 more
doaj   +1 more source

Thrombotic microangiopathies: thrombotic thrombocytopenic purpura / hemolytic uremic syndrome [PDF]

, 2010
Thrombotic microangiopathies (TMAs) are pathological conditions characterized by generalized microvascular occlusion by platelet thrombi, thrombocytopenia, and microangiopathic hemolytic anemia.
Mastroianni Kirsztajn, Gianna, Polito, Maria Goretti   +1 more
core   +2 more sources

ADAMTS13 Deficiency Worsens Colitis and Exogenous ADAMTS13 Administration Decreases Colitis Severity in Mice

TH Open, 2017
Background Inflammatory bowel disease (IBD) affects 1.6 million people in the United States. IBD is associated with an increased risk of thrombosis, which rises with disease activity.
Naamah L. Zitomersky, Melanie Demers, Kimberly Martinod, Maureen Gallant, Stephen M. Cifuni, Amlan Biswas, Scott Snapper, Denisa D. Wagner   +7 more
doaj   +1 more source

The Role of the Pulmonary Vascular Microenvironment in Chronic Thromboembolic Pulmonary Hypertension

Pulmonary Circulation, Volume 15, Issue 3, July 2025.
ABSTRACT Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by persistent obstruction and vascular remodeling of the pulmonary arteries following pulmonary thromboembolism (PTE), diagnosed after a minimum of 3 months of therapeutic anticoagulation. Disease progression from PTE to CTEPH takes place in the pulmonary circulation, where
Lu Sun, Han Tian, Jixiang Liu, Min Liu, Yuhan Li, Haobo Li, Ran Miao, Yunxia Zhang, Wanmu Xie, Zhu Zhang, Shiqing Xu, Peiran Yang, Zhenguo Zhai   +12 more
wiley   +1 more source