Atypical hemolytic uremic syndrome : update on the complement system and what is new [PDF]
, 2010 Atypical hemolytic uremic syndrome (aHUS) is a rare disease of microangiopathic hemolytic anemia, thrombocytopenia, and predominant renal impairment. It is characterized by the absence of Shiga toxin-producing bacteria as a triggering factor.
Dickenmann, Michael +2 more
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Circulating Proteomics and Risk of Atrial Fibrillation: A Systematic Review of Cohort Studies
Journal of Cellular and Molecular Medicine, Volume 29, Issue 15, August 2025.ABSTRACT Atrial fibrillation (AF) is a common arrhythmia associated with significant morbidity and adverse outcomes. High‐throughput proteomics offers a promising approach for identifying circulating biomarkers to improve AF risk stratification.
Luxiang Shang +4 more
wiley +1 more source
Destabilization of the von Willebrand factor A2 domain under oxidizing conditions investigated by molecular dynamics simulations. [PDF]
PLoS ONE, 2018 The protein von Willebrand factor (VWF) is key for the adhesion of blood platelets to sites of vascular injury. Recent studies have shown that the release of oxidative agents during inflammation increases the platelet-tethering activity of VWF ...
Gianluca Interlandi
doaj +1 more source
The effect of single nucleotide polymorphisms and mutations on congenital thrombotic thrombocytopenic purpura phenotype [PDF]
, 2017 Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disease with a reported incidence of 6 cases per million per year in the UK. It is characterised by episodes of microangiopathic haemolytic anaemia and thrombocytopenia, with the ...
Tate, H., Tate, H.
core
Critical Care, 2023 Background One of five global deaths are attributable to sepsis. Hyperferritinemic sepsis (> 500 ng/mL) is associated with increased mortality in single-center studies. Our pediatric research network’s objective was to obtain rationale for designing anti-
Zhenziang Fan +19 more
doaj +1 more source
The diagnosis and management of the haematologic manifestations of lupus [PDF]
, 2016 Haematological manifestations in systemic lupus erythematosus (SLE) are frequently observed. They are diverse and range from mild to severe.
Castro, SG +2 more
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Haemophilia, Volume 31, Issue 4, Page 734-742, July 2025.ABSTRACT Introduction Inherited coagulation factor deficiencies (ICFD) result from plasma protein deficiencies, impacting blood coagulation cascade and leading to haemorrhagic diathesis. Advancements in next‐generation sequencing (NGS) technology have enabled high‐throughput methods for molecular ICFD diagnosis.
Nina Borràs +17 more
wiley +1 more source
Plasma markers of COVID-19 severity: a pilot study
Respiratory Research, 2022 Background SARS-CoV-2 infected patients show heterogeneous clinical presentations ranging from mild symptoms to severe respiratory failure and death. Consequently, various markers reflect this wide spectrum of disease presentations.
Julia Beimdiek +12 more
doaj +1 more source
ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia-reperfusion injury [PDF]
, 2018 Highly adhesive glycoprotein von Willebrand factor (VWF) multimer induces platelet aggregation and leukocyte tethering or extravasation on the injured vascular wall, contributing to microvascular plugging and inflammation in brain ischemia-reperfusion. A
Akitake, Yoshiharu +16 more
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A rare case of renal thrombotic microangiopathy associated with Castleman’s disease [PDF]
, 2017 BACKGROUND: Castleman’s disease (CD) is an uncommon, heterogeneous lympho-proliferative disorder leading to high circulating levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF).
Chen, Ying Maggie +3 more
core +2 more sources