Results 91 to 100 of about 5,511,471 (226)

ProNet DB: A proteome-wise database for protein surface property representations and RNA-binding profiles [PDF]

arXiv, 2022
The rapid growth in the number of experimental and predicted protein structures and more complicated protein structures challenge users in computational biology for utilizing the structural information and protein surface property representation. Recently, AlphaFold2 released the comprehensive proteome of various species, and protein surface property ...
arxiv  

Kinetic modeling of the plasma pharmacokinetic profiles of ADAMTS13 fragment and its Fc-fusion counterpart in mice

Frontiers in Pharmacology
Introduction: Fusion of the fragment crystallizable (Fc) to protein therapeutics is commonly used to extend the circulation time by enhancing neonatal Fc-receptor (FcRn)-mediated endosomal recycling and slowing renal clearance. This study applied kinetic
Heechun Kwak, Min-Soo Kim, Suyong Kim, Jiyoung Kim, Yasunori Aoki, Suk-Jae Chung, Hyun-Ja Nam, Wooin Lee   +7 more
semanticscholar   +1 more source

Optimization of plasma-based BioID identifies plasminogen as a ligand of ADAMTS13

Scientific Reports
ADAMTS13, a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13, regulates the length of Von Willebrand factor (VWF) multimers and their platelet-binding activity. ADAMTS13 is constitutively secreted as an active protease and is
Hasam Madarati, Veronica DeYoung, Kanwal Singh, Taylor Sparring, Andrew C. Kwong, James C. Fredenburgh, Cherie Teney, Marlys L. Koschinsky, Michael B. Boffa, Jeffrey I. Weitz, Colin A. Kretz   +10 more
doaj   +1 more source

Coagulation Studies Are Not Predictive of Hematological Complications of COVID-19 Infection

TH Open, 2022
Objectives Thrombotic and bleeding complications are common in COVID-19 disease. In a prospective study, we performed a comprehensive panel of tests to predict the risk of bleeding and thrombosis in patients admitted with hypoxic respiratory failure due ...
Sarah Hadique, Varun Badami, Rahul Sangani, Michael Forte, Talia Alexander, Aarti Goswami, Adriana Garrison, Sijin Wen   +7 more
doaj   +1 more source

Elevated plasma neutrophil elastase concentration is associated with disease activity in patients with thrombotic thrombocytopenic purpura. [PDF]

, 2015
INTRODUCTION: Genetic and autoimmune risk factors contribute to the development of thrombotic thrombocytopenic purpura (TTP) but triggers are needed to bring about acute disease.
Brill, Brinkmann, Brinkmann, Bálint Mikes, Chapman, Chaturvedi, Chen, Clark, Clark, Derzsy, Dorottya Csuka, Falter, Fitzpatrick, Fuchs, Fujimura, Gombos, Gyula Domján, György Sinkovits, Hung, Ishikawa, Jagels, Judit Demeter, Karpman, Katalin Rázsó, Kessenbrock, Kremer Hovinga, Leffler, Marienn Réti, Massberg, Moatti-Cohen, Noris, Papayannopoulos, Peng, Peyvandi, Péter Farkas, Raife, Reti, Tsai, Urban, van Montfoort, Walters, Westwood1, Xu, Zoltán Prohászka, Ágota Schlammadinger   +44 more
core   +1 more source

Healthy Aging Metabolomic and Proteomic Signatures Across Multiple Physiological Compartments

Aging Cell, Volume 24, Issue 6, June 2025.
The association of the aging scores with the clinical covariates suggests increased inflammation, strong predisposition to iron deficiency anemia, decline in muscle mass, and renal and hepatic functions with accelerated aging. ABSTRACT The study of biomarkers in biofluids and tissues expanded our understanding of the biological processes that drive ...
R. Moaddel, J. Candia, C. Ubaida‐Mohien, T. Tanaka, A. Z. Moore, M. Zhu, G. Fantoni, S. Church, J. D'Agostino, J. Fan, N. Shehadeh, S. De, E. Lehrmann, M. Kaileh, E. Simonsick, R. Sen, J. M. Egan, L. Ferrucci   +17 more
wiley   +1 more source

Plasma level and clinical significance of ADAMTS13 in patients with primary membrous nephropathy

Linchuang shenzangbing zazhi, 2022
ObjectivePatients with primary membrous nephropathy （PMN） have an elevated risk of venous thromboembolism （VTE）. The aim of this study was to detect plasma level of ADAMTS13 in PMN patients complicated and uncomplicated by VTE and examine their clinical ...
Zhu Guo-qiang, Yang Shu-fen, Zhang Xue-qing, Lu Chen   +3 more
doaj  

The ADAMTS131239–1253 peptide is a dominant HLA-DR1-restricted CD4+ T-cell epitope

Haematologica, 2017
Acquired thrombotic thrombocytopenic purpura is a rare and severe disease characterized by auto-antibodies directed against “A Disintegrin And Metalloproteinase with Thrombospondin type 1 repeats, 13th member" (ADAMTS13), a plasma protein involved in ...
Laurent Gilardin, Sandrine Delignat, Ivan Peyron, Mathieu Ing, Yu-Chun Lone, Bagirath Gangadharan, Baptiste Michard, Yousra Kherabi, Meenu Sharma, Anastas Pashov, Jean-Baptiste Latouche, Mohamad Hamieh, Olivier Toutirais, Pascale Loiseau, Lionel Galicier, Agnès Veyradier, Srini Kaveri, Bernard Maillère, Paul Coppo, Sébastien Lacroix-Desmazes   +19 more
doaj   +1 more source

Destabilization of the von Willebrand factor A2 domain under oxidizing conditions investigated by molecular dynamics simulations. [PDF]

PLoS ONE, 2018
The protein von Willebrand factor (VWF) is key for the adhesion of blood platelets to sites of vascular injury. Recent studies have shown that the release of oxidative agents during inflammation increases the platelet-tethering activity of VWF ...
Gianluca Interlandi
doaj   +1 more source

Deletion of chromosome 20 in bone marrow of patients with Shwachman-Diamond syndrome, loss of the EIF6 gene and benign prognosis [PDF]

, 2012
Shwachman-Diamond Syndrome (SDS; On-line Mendelian Inheritance in Man database number 260400) is an autosomal recessive disorder caused by mutations in the SBDS gene in at least 90% of cases (Boocock et al, 2003).
Lo Curto F, Mare L, Marletta C, Maserati E, Montalbano G, Pasquali F, Pressato B, Valli R   +7 more
core   +1 more source