Results 101 to 110 of about 5,511,471 (226)

Involvement of the ADAMTS13–von Willebrand factor axis in acute kidney injury in mice with liver cirrhosis

Hepatology Research, Volume 55, Issue 6, Page 844-858, June 2025.
Abstract Aim Hepatorenal syndrome‐induced acute kidney injury (AKI) comprises AKI and liver cirrhosis (LC) and is a risk factor for poor prognoses of patients with LC. Decreased a disintegrin‐like metalloproteinase with thrombospondin type 1 motif 13 (ADAMTS13) activity and increased von Willebrand factor (vWF) antigen levels are associated with LC ...
Masayoshi Takami, Norihisa Nishimura, Kosuke Kaji, Nobuyuki Yorioka, Hiroyuki Masuda, Hiroaki Takaya, Koh Kitagawa, Shinya Sato, Tadashi Namisaki, Hitoshi Yoshiji   +9 more
wiley   +1 more source

Hyperferritinemic sepsis, macrophage activation syndrome, and mortality in a pediatric research network: a causal inference analysis

Critical Care, 2023
Background One of five global deaths are attributable to sepsis. Hyperferritinemic sepsis (> 500 ng/mL) is associated with increased mortality in single-center studies. Our pediatric research network’s objective was to obtain rationale for designing anti-
Zhenziang Fan, Kate F. Kernan, Yidi Qin, Scott Canna, Robert A. Berg, David Wessel, Murray M. Pollack, Kathleen Meert, Mark Hall, Christopher Newth, John C. Lin, Allan Doctor, Tom Shanley, Tim Cornell, Rick E. Harrison, Athena F. Zuppa, Katherine Sward, J. Michael Dean, H. J. Park, Joseph A. Carcillo   +19 more
doaj   +1 more source

Kinetics and Thermodynamics of Membrane Protein Folding [PDF]

Biomolecules 2014, 4(1), 354-373, 2014
Understanding protein folding has been one of the great challenges in biochemistry and molecular biophysics. Over the past 50 years, many thermodynamic and kinetic studies have been performed addressing the stability of globular proteins. In comparison, advances in the membrane protein folding field lag far behind. Although membrane proteins constitute
arxiv   +1 more source

A case of refractory thrombotic thrombocytopenic purpura treated with plasmapheresis and rituximab [PDF]

, 2016
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disorder with no prevalence or incidence studies in sub-Saharan Africa. Acquired TTP has several causes, all of which lead to decreased activity of von Willebrand factor cleaving ...
Kirui, Nicholas, Sokwala, Ahmed
core   +4 more sources

Plasma markers of COVID-19 severity: a pilot study

Respiratory Research, 2022
Background SARS-CoV-2 infected patients show heterogeneous clinical presentations ranging from mild symptoms to severe respiratory failure and death. Consequently, various markers reflect this wide spectrum of disease presentations.
Julia Beimdiek, Sabina Janciauskiene, Sabine Wrenger, Sonja Volland, Adriana Rozy, Jan Fuge, Beata Olejnicka, Isabell Pink, Thomas Illig, Alexander Popov, Joanna Chorostowska, Falk F. R. Buettner, Tobias Welte   +12 more
doaj   +1 more source

Nonsense-mediated mRNA decay in the ADAMTS13 gene caused by a 29-nucleotide deletion

Haematologica, 2008
Background In mammalian cells a regulatory mechanism, known as nonsense-mediated mRNA decay, degrades mRNA harboring premature termination codons. This mechanism is intron-dependent and functions as a quality control mechanism to eliminate abnormal ...
Isabella Garagiola, Carla Valsecchi, Silvia Lavoretano, Hale Oren, Martina Bohm, Flora Peyvandi   +5 more
doaj   +1 more source

MEGADOCK-Web-Mito: human mitochondrial protein-protein interaction prediction database [PDF]

arXiv, 2021
Mitochondrial diseases are largely caused by dysfunction in mitochondrial proteins. However, annotations of human mitochondrial proteins are scattered across various public databases and individual studies. To facilitate research aimed at elucidating mitochondrial functions, we constructed the MEGADOCK-Web-Mito database as a protein-protein interaction
arxiv  

The effect of single nucleotide polymorphisms and mutations on congenital thrombotic thrombocytopenic purpura phenotype [PDF]

, 2017
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disease with a reported incidence of 6 cases per million per year in the UK. It is characterised by episodes of microangiopathic haemolytic anaemia and thrombocytopenia, with the ...
Tate, H., Tate, H.
core  

First-line therapy in atypical hemolytic uremic syndrome: consideration on infants with a poor prognosis. [PDF]

, 2014
BackgroundAtypical hemolytic uremic syndrome (aHUS) is a rare and heterogeneous disorder. The first line treatment of aHUS is plasma therapy, but in the past few years, the recommendations have changed greatly with the advent of eculizumab, a humanized ...
A Szilagyi, Aspazija Sofijanova, Attila Szabó, C Loirat, CM Legendre, D Kavanagh, D Magen, F Fakhouri, F Fakhouri, G Ariceta, G Ariceta, György Reusz, J Caprioli, J Zuber, J Zuber, JM Campistol, Klaus Arbeiter, Krisztina Rusai, Lilla Szeifert, LM Geerdink, M Christmann, M Heurich, M Jozsi, M Lemaire, M Reti, MA Abrera-Abeleda, MA Dragon-Durey, Miklós Szabó, N Besbas, Nóra Szarvas, RA Gruppo, RL Ruebner, S Jung, Thomas Müller, Valbona Nushi-Stavileci, Velibor Tasic, Z Prohaszka, Zoltán Prohászka, Zoran Gucev, Ágnes Szilágyi   +39 more
core   +1 more source

Knowledge-based energy functions for computational studies of proteins [PDF]

, 2006
This chapter discusses theoretical framework and methods for developing knowledge-based potential functions essential for protein structure prediction, protein-protein interaction, and protein sequence design. We discuss in some details about the Miyazawa-Jernigan contact statistical potential, distance-dependent statistical potentials, as well as ...
arxiv   +1 more source