Results 111 to 120 of about 5,529,499 (207)
Blood, 2019 The metalloprotease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats member 13) prevents microvascular thrombosis by cleaving von Willebrand factor (VWF) within platelet-rich thrombi, and cleavage depends on allosteric ...
J. Muia +6 more
semanticscholar +1 more source
Biocompatibility and antibacterial properties of zirconium nitride coating on titanium abutments: An in vitro study [PDF]
, 2018 Improving soft tissue attachment and reducing bacterial colonization on titanium abutments are key factors for the long-term maintenance of healthy soft and hard peri-implant tissues.
Bressan, Eriberto +7 more
core +2 more sources
Healthy Aging Metabolomic and Proteomic Signatures Across Multiple Physiological Compartments
Aging Cell, Volume 24, Issue 6, June 2025.The association of the aging scores with the clinical covariates suggests increased inflammation, strong predisposition to iron deficiency anemia, decline in muscle mass, and renal and hepatic functions with accelerated aging. ABSTRACT The study of biomarkers in biofluids and tissues expanded our understanding of the biological processes that drive ...
R. Moaddel +17 more
wiley +1 more source
Hepatology Research, Volume 55, Issue 6, Page 844-858, June 2025.Abstract Aim Hepatorenal syndrome‐induced acute kidney injury (AKI) comprises AKI and liver cirrhosis (LC) and is a risk factor for poor prognoses of patients with LC. Decreased a disintegrin‐like metalloproteinase with thrombospondin type 1 motif 13 (ADAMTS13) activity and increased von Willebrand factor (vWF) antigen levels are associated with LC ...
Masayoshi Takami +9 more
wiley +1 more source
Blood, 2019 Human ADAMTS13 is a multidomain protein with metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C), and spacer (S) domains, followed by 7 additional T domains and 2 CUB (complement components C1r and C1s, sea urchin protein Uegf ...
Jian Zhu +6 more
semanticscholar +1 more source
Conformational activation of ADAMTS13 [PDF]
, 2014 A disintegrin and metalloprotease with thrombospondin motifs 13 (ADAMTS13) is a metalloprotease that regulates von Willebrand factor (VWF) function. ADAMTS13-mediated proteolysis is determined by conformational changes in VWF, but also may depend on its ...
Collins, RF +8 more
core +1 more source
A Single Synonymous Variant (c.354G>A [p.P118P]) in ADAMTS13 Confers Enhanced Specific Activity
International Journal of Molecular Sciences, 2019 Synonymous variants within coding regions may influence protein expression and function. We have previously reported increased protein expression levels ex vivo (~120% in comparison to wild-type) from a synonymous polymorphism variant, c.354G>A [p.P118P],
R. Hunt +20 more
semanticscholar +1 more source
, 2014 Thrombocytopenia means low platelet count. This is the most frequent cause of bleeding abnormalities. Petechias, purpuras, mucosal bleeding are typical clinical findings.
Domján, Gyula, Gadó, Klára
core +1 more source
mRNA treatment produces sustained expression of enzymatically active human ADAMTS13 in mice
Scientific Reports, 2018 Thrombotic thrombocytopenic purpura (TTP) is primarily caused by deficiency of ADAMTS13 within the blood stream due to either genetic defects or presence of inhibitory autoantibodies.
Susan Liu-Chen +4 more
semanticscholar +1 more source
Thrombotic Thrombocytopenic Purpura in Oman: Disease Burden and Outcomes
Oman Medical JournalObjectives: Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening autoimmune disorder; limited information about this disease is available from the Middle East.
Samata Al Dowaiki +4 more
doaj +1 more source