Results 11 to 20 of about 8,735 (203)

ADAMTS13 in Bothrops lanceolatus snakebite envenoming: Crude venom-induced reduction of in vitro enzymatic activity and clinical correlation in snakebite patients. [PDF]

PLoS Neglected Tropical Diseases
BackgroundEnvenoming by Bothrops lanceolatus, a viperid endemic to Martinique an island in the Lesser Antilles, induces a unique clinical manifestation, i.e., thrombosis. Pathophysiological signaling leading to thrombotic events remains poorly understood.
Jonathan Florentin, Caroline Rapon, Olivier Pierre-Louis, Fatima Radouani, Prisca Jalta, Pascal Fuseau, Hatem Kallel, Remi Neviere, Dabor Resiere   +8 more
doaj   +2 more sources

Overview of ADAMTS13 Protein in Diagnosis and Patient Management of TTP [PDF]

Documenta Haematologica
The accurate diagnosis and effective management of Thrombotic Thrombocytopenic Purpura (TTP), a rare but life-threatening hematologic disorder, rely critically on the assessment of ADAMTS13 activity.
Georgiana GHERGHE, Valentina USCATESCU, Delia Codruta POPA, Diana PREDA, Didona VASILACHE, Mihai Emanuel HIMCINSCHI, Horia SANDU, Daniel CORIU   +7 more
doaj   +2 more sources

Unraveling antibody-induced structural dynamics in the ADAMTS13 CUB1-2 domains via HDX-MS [PDF]

Blood Advances
: Allosteric regulation of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type-1 motif, member 13) activity involves an interaction between its spacer (S) and 2 complement C1r/C1s, Uegf and BMP1 (CUB; CUB1-2) domains to keep the enzyme
Quintijn Bonnez, Emily R. Legan, Inge Pareyn, Febe Boudry, Jennifer Anckaert, Claudia Tersteeg, Simon F. De Meyer, Renhao Li, Karen Vanhoorelbeke   +8 more
doaj   +2 more sources

Aberrant Expression of A Disintegrin and Metalloproteinase With Thrombospondin Motifs 13 (ADAMTS13) in Pancreatic Cancer Leads to Dichotomic Functions. [PDF]

MedComm (2020)
Allmang et al. demonstrated that ADAMTS13 is overexpressed in PDAC, associated with prolonged survival and reduced vascular density. Knockout of ADAMTS13 in PDAC cells led to a decrease in migration and invasion. In a xenograft model, loss of ADAMTS13 altered angiogenesis, vascular maturation, and reduced the expression of key angiogenic factors ...
Allmang S, Witzel HR, Hausen A, Marquard S, Eckert C, Marnet N, Hörner N, Mayer P, Heinrich S, Dang H, Roth W, Gaida MM.   +11 more
europepmc   +2 more sources

Inherited ADAMTS13 mutations associated with Thrombotic Thrombocytopenic Purpura: a short review and update

Platelets, 2023
ADAMTS13 is a plasma metalloprotease with the primary function of cleaving VWF to maintain hemostasis. Circulating ADAMTS13 is in the closed conformation until blood vessel injury triggers a VWF-dependant activation to the open active form of the protein.
Zoe Markham-Lee, Neil V. Morgan, Jonas Emsley   +2 more
doaj   +1 more source

Characterization of ADAMTS13 and von Willebrand factor levels in septic and non-septic ICU patients.

PLoS ONE, 2021
Sepsis is a life-threatening disease characterized by excessive host response to infection that can lead to activation of the coagulation system. Von Willebrand Factor (VWF) and ADAMTS13 are important regulators of hemostasis and their dysregulation ...
Kanwal Singh, Andrew C Kwong, Hasam Madarati, Sharumathy Kunasekaran, Taylor Sparring, Alison E Fox-Robichaud, Patricia C Liaw, Colin A Kretz   +7 more
doaj   +1 more source

Localization of blood proteins thrombospondin1 and ADAMTS13 to cerebral corpora amylacea [PDF]

Neuropathology, 2009
Corpora amylacea (CA) have long been described in aging brains and in patients with neurodegenerative conditions, but their origins have been debated. It has been proposed that CA represent collections of nervous system breakdown products that accumulate within astrocytic cytoplasm.
Meng, He, Zhang, Xiaojie, Blaivas, Mila, Wang, Michael M.   +3 more
openaire   +3 more sources

Synonymous ADAMTS13 variants impact molecular characteristics and contribute to variability in active protein abundance

Blood Advances, 2022
The effects of synonymous single nucleotide variants (sSNVs) are often neglected since they do not alter protein primary structure. Nevertheless, there is growing evidence that synonymous variations may impact mRNA expression, protein conformation and activity which may lead to protein deficiency and disease manifestations.
Katarzyna Izabela Jankowska, Douglas Meyer, David Dillon Fisher Holcomb, Jacob Kames, Nobuko Hamasaki-Katagiri, Upendra K. Katneni, Ryan C. Hunt, Juan C. Ibla, Chava Kimchi-Sarfaty   +8 more
openaire   +2 more sources

Characterization of conformation-sensitive antibodies to ADAMTS13, the von Willebrand cleavage protease. [PDF]

PLoS ONE, 2009
BACKGROUND:The zinc metalloprotease ADAMTS13 is a multidomain protein that cleaves von Willebrand Factor (VWF) and is implicated in Thrombotic Thrombocytopenic Purpura (TTP) pathogenesis.
Zuben E Sauna, Chinyere Okunji, Ryan C Hunt, Tanvi Gupta, Courtni E Allen, Elizabeth Plum, Adam Blaisdell, Vahan Grigoryan, S Geetha, Robert Fathke, Kenji Soejima, Chava Kimchi-Sarfaty   +11 more
doaj   +1 more source

ADAMTS13 levels in a plasma-derived FVIII concentrate: A potential therapeutic option for patients with congenital thrombotic thrombocytopenic purpura

Thrombosis Update, 2022
Introduction: Treatment of congenital thrombotic thrombocytopenic purpura (cTTP), a disease characterized by the congenital deficiency of ADAMTS13, remains a challenge as there are no specific treatments available yet, other than therapy based on the use
Filippo Mori, Ilaria Nardini, Silvia Nannizzi, Roberto Crea, Prasad Mathew, Nicole Ziliotto, Alessandro Gringeri   +6 more
doaj   +1 more source