Results 81 to 90 of about 5,511,471 (226)

Virtual Identification of Essential Proteins Within the Protein Interaction Network of Yeast [PDF]

, 2005
Topological analysis of large scale protein-protein interaction networks (PINs) is important for understanding the organisational and functional principles of individual proteins. The number of interactions that a protein has in a PIN has been observed to be correlated with its indispensability.
arxiv   +1 more source

Performance related factors are the main determinants of the von Willebrand factor response to exhaustive physical exercise [PDF]

, 2014
Background: Physical stress triggers the endothelium to release von Willebrand Factor (VWF) from the Weibel Palade bodies. Since VWF is a risk factor for arterial thrombosis, it is of great interest to discover determinants of VWF response to physical ...
A Casonato, AM Keightley, AO Spiel, BC Creighton, CH Widberg, DD Wagner, DJ Pinsky, EM Bladbjerg, Frank W. G. Leebeek, G Lippi, G Lippi, G Rock, GY Lip, H Tanaka, I Martinelli, IM Lee, J Myers, J Ribeiro, J Stakiw, Janine E. van Loon, JB Hansen, JC Souto, JE Sadler, JE van Loon, JL Ribeiro, JP Giblin, JR Day, L Gallinaro, LA Sporn, M de Lange, M Small, MC van Schie, MD Delp, Michelle A. H. Sonneveld, MJ Hollestelle, Moniek P. M. de Maat, MP Reilly, MS El-Sayed, MS El-Sayed, N Hickson, NL Smith, NL Smith, O Wu, PH Whincup, PJ Harvey, RA Claus, RA Reiter, RG Wieberdink, S Kanaji, S Lethagen, Stephan F. E. Praet, T Mayadas, Toshiyuki Miyata, V Daidone, YY Zhang   +54 more
core   +4 more sources

Pathogenic variants prevalence patients with diabetic kidney disease in Japan: A descriptive study

Journal of Diabetes Investigation, EarlyView.
Previous studies have identified pathogenic variants in 22% of Caucasian patients with diabetic kidney disease (DKD); however, this proportion may vary depending on ethnicity and updates to the database. Whole‐genome sequencing of 79 patients with DKD in Japan revealed that 34.1% had kidney‐related heterozygous pathogenic variants, and 12.7% had ...
Toyohiro Hashiba, Yuka Sugawara, Yosuke Hirakawa, Dai Sato, Reiko Inagi, Masaomi Nangaku   +5 more
wiley   +1 more source

The effects of coagulation factors on the risk of endometriosis: a Mendelian randomization study

BMC Medicine, 2023
Background Endometriosis is recognized as a complex gynecological disorder that can cause severe pain and infertility, affecting 6–10% of all reproductive-aged women.
Yan Li, Hongyan Liu, Shuting Ye, Bumei Zhang, Xiaopei Li, Jiapei Yuan, Yongrui Du, Jianmei Wang, Yang Yang   +8 more
doaj   +1 more source

Length, Protein-Protein Interactions, and Complexity [PDF]

, 2004
The evolutionary reason for the increase in gene length from archaea to prokaryotes to eukaryotes observed in large scale genome sequencing efforts has been unclear. We propose here that the increasing complexity of protein-protein interactions has driven the selection of longer proteins, as longer proteins are more able to distinguish among a larger ...
arxiv   +1 more source

PROTEOLYTIC PROCESSING OF VON WILLEBRAND FACTOR BY ADAMTS13 AND LEUKOCYTE PROTEASES

Mediterranean Journal of Hematology and Infectious Diseases, 2013
ADAMTS13 is a 190 kDa zinc protease encoded by a gene located on chromosome 9q34.   This protease specifically hydrolyzes von Willebrand factor (VWF) multimers, thus causing VWF size reduction.
Stefano Lancellotti, Maria Basso, Raimondo De Cristofaro   +2 more
doaj   +1 more source

Cleavage of von Willebrand factor by granzyme M destroys its factor VIII binding capacity. [PDF]

PLoS ONE, 2011
Von Willebrand factor (VWF) is a pro-hemostatic multimeric plasma protein that promotes platelet aggregation and stabilizes coagulation factor VIII (FVIII) in plasma.
Martine J Hollestelle, Ka Wai Lai, Marcel van Deuren, Peter J Lenting, Philip G de Groot, Tom Sprong, Niels Bovenschen   +6 more
doaj   +1 more source

Expert Statements on the Standard of Care in Critically Ill Adult Patients With Atypical Hemolytic Uremic Syndrome. [PDF]

, 2017
A typical hemolytic uremic syndrome (aHUS) presents similarly to thrombotic thrombocytopenic purpura (TTP) and other causes or conditions with thrombotic microangiopathy (TMA), such as disseminated intravascular coagulation or sepsis.
Abroug, F., Azoulay, E., Benoit, D., Eggimann, P., Galstian, G., Garnacho-Montero, J., Knoebl, P., Rusinova, K., Scully, M., von Bergwelt-Baildon, M., Wendon, J.   +10 more
core   +3 more sources

Bethesda Assay for Detecting Inhibitory Anti-ADAMTS13 Antibodies in Immune-Mediated Thrombotic Thrombocytopenic Purpura

TH Open, 2018
A diagnosis of thrombotic thrombocytopenic purpura (TTP) is confirmed by a severe deficiency (
Chiara Vendramin, Mari Thomas, John-Paul Westwood, Marie Scully   +3 more
doaj   +1 more source

ADAMTS13 in the New Era of TTP

International Journal of Molecular Sciences
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening, often immune-mediated disease that affects 2–13 persons per million per year.
Anna Papakonstantinou, Panagiotis Kalmoukos, Aikaterini Mpalaska, Evaggelia-Evdoxia Koravou, E. Gavriilaki   +4 more
semanticscholar   +1 more source