Results 81 to 90 of about 5,529,499 (207)

Bleeding Complications in JAK2‐Variant Essential Thrombocythemia: A Revisit in 2025

eJHaem, Volume 6, Issue 4, August 2025.
ABSTRACT Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterised by sustained thrombocytosis. Paradoxically, bleeding complications remain an under‐recognised clinical challenge. Compared with CALR‐mutated patients, those harbouring the JAK2‐V617F variant appear more prone to haemorrhage.
Gerard Gurumurthy, Samantha Gurumurthy, Tim C. P. Somervaille, Anna Falanga, Jecko Thachil   +4 more
wiley   +1 more source

Kinetic modeling of the plasma pharmacokinetic profiles of ADAMTS13 fragment and its Fc-fusion counterpart in mice

Frontiers in Pharmacology
Introduction: Fusion of the fragment crystallizable (Fc) to protein therapeutics is commonly used to extend the circulation time by enhancing neonatal Fc-receptor (FcRn)-mediated endosomal recycling and slowing renal clearance. This study applied kinetic
Heechun Kwak, Min-Soo Kim, Suyong Kim, Jiyoung Kim, Yasunori Aoki, Suk-Jae Chung, Hyun-Ja Nam, Wooin Lee   +7 more
semanticscholar   +1 more source

Optimization of plasma-based BioID identifies plasminogen as a ligand of ADAMTS13

Scientific Reports
ADAMTS13, a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13, regulates the length of Von Willebrand factor (VWF) multimers and their platelet-binding activity. ADAMTS13 is constitutively secreted as an active protease and is
Hasam Madarati, Veronica DeYoung, Kanwal Singh, Taylor Sparring, Andrew C. Kwong, James C. Fredenburgh, Cherie Teney, Marlys L. Koschinsky, Michael B. Boffa, Jeffrey I. Weitz, Colin A. Kretz   +10 more
doaj   +1 more source

Bethesda Assay for Detecting Inhibitory Anti-ADAMTS13 Antibodies in Immune-Mediated Thrombotic Thrombocytopenic Purpura

TH Open, 2018
A diagnosis of thrombotic thrombocytopenic purpura (TTP) is confirmed by a severe deficiency (
Chiara Vendramin, Mari Thomas, John-Paul Westwood, Marie Scully   +3 more
doaj   +1 more source

Plasma von Willebrand factor levels predict in-hospital survival in patients with acute-on-chronic liver failure [PDF]

, 2016
BACKGROUND AND AIMS: Circulating levels of von Willebrand factor (vWF) predict mortality in patients with cirrhosis. We hypothesized that systemic inflammation in acute-on-chronic liver failure (ACLF) will stimulate endothelium, increase vWF levels, and ...
Amirtharaj, GJ, Balasubramanian, KA, Eapen, CE, Elias, E, Goel, A, Mackie, I, Prasanna, KS, Ramachandran, A, Sajith, KG, Zachariah, U   +9 more
core   +1 more source

Efficacy of High‐Dose Intravenous Anakinra in Pediatric TAFRO Syndrome: Report of Two Cases and Literature Review

Pediatric Blood &Cancer, Volume 72, Issue 8, August 2025.
ABSTRACT TAFRO (thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly) syndrome is a rare, life‐threatening inflammatory condition linked to infections, neoplasms, and idiopathic multicentric Castleman disease. Interleukin (IL)‐6 inhibitors are the primary treatment, but refractory cases require alternatives. This
Serena Palmeri, Jacopo Ferro, Valentina Natoli, Caterina Matucci‐Cerinic, Riccardo Papa, Silvia Rosina, Stefania Sorrentino, Stefano Volpi, Valerio Gaetano Vellone, Marco Gattorno, Roberta Caorsi   +10 more
wiley   +1 more source

Biomarkers of Cellular Senescence in Type 2 Diabetes Mellitus

Aging Cell, Volume 24, Issue 8, August 2025.
In cohorts of lean controls, obese participants without Type 2 Diabetes Mellitus (T2DM) and obese T2DM participants, we find that T‐cell expression of senescence biomarkers is altered only in the T2DM participants and not with obesity alone. Moreover, high T‐cell p16 expression in the T2DM participants is associated with impaired bone cortical indices.
Caroline Hoong, Joshua N. Farr, David G. Monroe, Thomas A. White, Elizabeth J. Atkinson, Amanda Tweed, Allyson K. Palmer, Nathan K. LeBrasseur, Jad G. Sfeir, Sundeep Khosla   +9 more
wiley   +1 more source

Plasma level and clinical significance of ADAMTS13 in patients with primary membrous nephropathy

Linchuang shenzangbing zazhi, 2022
ObjectivePatients with primary membrous nephropathy （PMN） have an elevated risk of venous thromboembolism （VTE）. The aim of this study was to detect plasma level of ADAMTS13 in PMN patients complicated and uncomplicated by VTE and examine their clinical ...
Zhu Guo-qiang, Yang Shu-fen, Zhang Xue-qing, Lu Chen   +3 more
doaj  

The ADAMTS131239–1253 peptide is a dominant HLA-DR1-restricted CD4+ T-cell epitope

Haematologica, 2017
Acquired thrombotic thrombocytopenic purpura is a rare and severe disease characterized by auto-antibodies directed against “A Disintegrin And Metalloproteinase with Thrombospondin type 1 repeats, 13th member" (ADAMTS13), a plasma protein involved in ...
Laurent Gilardin, Sandrine Delignat, Ivan Peyron, Mathieu Ing, Yu-Chun Lone, Bagirath Gangadharan, Baptiste Michard, Yousra Kherabi, Meenu Sharma, Anastas Pashov, Jean-Baptiste Latouche, Mohamad Hamieh, Olivier Toutirais, Pascale Loiseau, Lionel Galicier, Agnès Veyradier, Srini Kaveri, Bernard Maillère, Paul Coppo, Sébastien Lacroix-Desmazes   +19 more
doaj   +1 more source

Coagulation Studies Are Not Predictive of Hematological Complications of COVID-19 Infection

TH Open, 2022
Objectives Thrombotic and bleeding complications are common in COVID-19 disease. In a prospective study, we performed a comprehensive panel of tests to predict the risk of bleeding and thrombosis in patients admitted with hypoxic respiratory failure due ...
Sarah Hadique, Varun Badami, Rahul Sangani, Michael Forte, Talia Alexander, Aarti Goswami, Adriana Garrison, Sijin Wen   +7 more
doaj   +1 more source