Results 101 to 110 of about 2,930,787 (173)

The protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25 [PDF]

Ovarian cancer is the 3rd most common gynaecological malignancy worldwide, with a 5-year survival rate of
Adams, Jamie, Adams, J., Bacchetti, R., Nuti, Elisa, Santamaria, Salvatore, Yuan, Shengnan, Bacchetti, Rachele, Yuan, S., Santamaria, S., Cuffaro, Doretta, Cuffaro, D., Rossello, A., Nuti, E., Rossello, Armando, Rainero, Elena, Rainero, E.   +15 more
core   +1 more source

ADAMTS1 and ADAMTS5 metalloproteases produced by Sertoli cells: a potential diagnostic marker in azoospermia

, 2018
In this study, our aim was to detect protein levels of A Disintegrin and Metalloproteinase with Thrombospondin Motifs 1 and 5 (ADAMTS1 and ADAMTS5) proteases and to examine the effect of in vitro FSH supplementation on protease production in cultured ...
Oya Sena Aydos, Ozkavukcu, Sinan; id_orcid, Asuman Sunguroglu, Yunus Yukselten, Aydos, Kaan, Kaan Aydos, Aydos, Oya Sena, Yukselten, Yunus, Sinan Ozkavukcu, Sunguroglu, Asuman   +9 more
core   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science
Osteoarthritis (OA) progression involves cartilage degeneration, inflammation, and pain. Recent evidence suggests that the voltage‐gated sodium channel Nav1.7, encoded by Scn9a, links nociceptive signaling with chondrocyte metabolic regulation.
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
doaj   +1 more source

Enhancing protein-protein docking by new approaches to protein flexibility and scoring of docking hypotheses [PDF]

, 2004
Zöllner FG. Enhancing protein-protein docking by new approaches to protein flexibility and scoring of docking hypotheses. Bielefeld (Germany): Bielefeld University; 2004.Für das Verständnis von biologischen Funktionen können Proteindockingverfahren ...
Frank G. Zöllner, Zöllner, Frank Gerrit   +1 more
core  

Study on the mechanism of acupotomy in regulating oxidative stress injury of cartilage in rabbits with knee osteoarthritis via the Sirt1/Nrf2/NQO1 signaling pathway

针刺研究
ObjectiveTo observe the effect of acupotomy on the sirtuin 1 （Sirt1）/ nuclear factor erythroid 2-related factor 2 （Nrf2）/ NAD（P）H： quinone oxidoreductase 1（NQO1） signaling pathway of oxidative stress in the cartilage tissue of rabbits with knee ...
Wang Min, Zhang Zhaoqing, Cao Yuwei, Li Kai, Zhang Zhe, An Kang, Luo Xiaojuan   +6 more
doaj  

Investigating the role of the protease ADAMTS5 in ovarian cancer [PDF]

Ovarian cancer (OC) is the fifth most lethal gynaecologic malignancy in the UK. At the advanced stages (III and IV), there are peritoneal or distant metastases outside the peritoneal cavity, and the 5-year survival rate is less than 35%. Therefore, it is
Yuan, Shengnan
core  

ADAMTS5 expression and function in myoblast fusion and muscle regeneration

, 2016
This research investigated the role of an enzyme called ADAMTS5 in models of skeletal muscle regeneration and muscular dystrophy. This work has led to further investigations to better understand how ADAMTS5 and related proteins may be targeted as a ...
C Kintakas (14067363)
core  

Knockin expression of human ADAMTS5 impairs cardiovascular development and aggravates cerebral cavernous malformations in mice. [PDF]

Dis Model Mech
Yang X, Zhang J, Dai Z, Yang T, Xie L, Gao F, Zheng X, Han Z.   +7 more
europepmc   +1 more source

ECM remodelling by ADAMTS5 regulates influenza-specific immunity

, 2016
ECM remodelling by ADAMTS5 regulates influenza-specific ...
M McMahon (9882155), R Tripp (13658323), L Izzard (13466532), D McCulloch (13293555), John Stambas (13077333), S Ye (7645880)   +5 more
core  

Exploration on the mechanism of warm needle-moxibustion in protecting cartilage in rabbits with knee osteoarthritis based on the Hippo-YAP signaling pathway

针刺研究
ObjectiveTo observe the effect of warm-needle moxibustion on the synthesis and catabolism of extracellular matrix （ECM） in chondrocytes by regulating the Hippo-YAP signaling pathway in rabbits with knee osteoarthritis （KOA）， so as to explore its ...
LI Wen, LIU Di, WANG Ming-lei, WU Yong-li   +3 more
doaj