Results 81 to 90 of about 2,930,787 (173)

Genetic variation of aggrecanase-2 (ADAMTS5) in susceptibility to osteoarthritis

, 2019
Aggrecanase-2 (ADAMTS5) gene is responsible for aggrecan degradation that may contribute to cartilage destruction in a mouse osteoarthritis (OA) model. We aimed to investigate the effects of ADAMTS5 gene polymorphisms on OA risk in a Chinese population ...
Yong Huang, Nanwei Xu, Yi Zhang, Junjie Zhang, Dong Zhou, Xindie Zhou, Lifeng Jiang, Lidong Wu   +7 more
core   +2 more sources

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, Volume 13, Issue 44, 7 August 2026.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

The Zonal Architecture of the Mandibular Condyle Requires ADAMTS5

, 2018
Temporomandibular joint (TMJ) osteoarthritis (TMJOA) disrupts extracellular matrix (ECM) homeostasis, leading to cartilage degradation. Upregulated a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)–5 leads to cleavage of its ...
C.B. Kern, S.E. Cisewski, A.W. Rogers
core   +1 more source

Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5 [PDF]

, 2014
Proteolysis of the Glu(441)-Ala(442) bond in the glycosaminoglycan (GAG) β domain of the versican-V1 variant by a disintegrin-like and metalloproteinase domain with thrombospondin type 1 motif (ADAMTS) proteases is required for proper embryo ...
Dours-Zimmermann, Maria T, Larkin, Jonathan, Foulcer, Simon J, Quintero, Maritza V, Zimmermann, Dieter R, Nelson, Courtney M, Kuberan, Balagurunathan, Apte, Suneel S   +7 more
core   +1 more source

Eugenol preserves chondrocyte extracellular matrix homeostasis by modulating the ALK1/ALK5-associated TGF-β/Smad signaling axis

Frontiers in Pharmacology
Osteoarthritis (OA) is characterized by inflammatory and catabolic disruption of cartilage extracellular matrix (ECM) homeostasis. An increased relative abundance of activin receptor-like kinase 1 (ALK1) relative to ALK5, together with altered Smad ...
Yongcan Wang, Ying Wang, Shan Li, Xi Chen, Yaopu Hou, Chao Wang, Yanzhuo Zhang, Jianfeng Tao, Chengai Wu, Xu Jiang   +9 more
doaj   +1 more source

ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures [PDF]

, 2006
SummaryObjectiveAggrecan degradation by aggrecanases [a disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) 1, 4, 5, 8, 9, 15] is considered to initiate much of the cartilage pathology seen in human arthritis, however, the ...
Osborn, B., Sandy, J.D., Plaas, A., Fosang, A.J., Stewart, M.C., Bai, Y.   +5 more
core   +1 more source

Protein-RNA interactions: a structural analysis [PDF]

, 2001
A detailed computational analysis of 32 protein-RNA complexes is presented. A number of physical and chemical properties of the intermolecular interfaces are calculated and compared with those observed in protein-double-stranded DNA and protein-single ...
Daley, DT, Berman, HM, Luscombe, NM, Helen M Berman (10123868), Susan Jones (4079), Thornton, JM, David T A Daley (16115222), Janet M Thornton (16060073), Jones, S, Nicholas M Luscombe (8114756)   +9 more
core  

Peroxisomal membrane proteins insert into the endoplasmic reticulum [PDF]

, 2010
We show that a comprehensive set of 16 peroxisomal membrane proteins (PMPs) encompassing all types of membrane topologies first target to the endoplasmic reticulum (ER) in Saccharomyces cerevisiae.
Sub Cellular Protein Chemistry, van der Zand, A., Tabak, H.F., Braakman, L.J., Cellular Protein Chemistry   +4 more
core   +1 more source

Rivaroxaban suppresses factor Xa–Driven PAR-2–ERK inflammatory, catabolic, osteoclastogenic, and mitochondrial dysfunction signaling in osteoarthritis-relevant chondrocytes: a drug-repurposing strategy for joint inflammation

Frontiers in Pharmacology
BackgroundOsteoarthritis (OA) is increasingly recognised as an inflammation-driven whole-joint disease in which cartilage catabolism, osteochondral remodelling, and mitochondrial dysfunction drive structural progression.
Rajashree Patnaik, Shirin Jannati, Catherine F. Kellett, Catherine F. Kellett, Caroline B. Hing, Yajnavalka Banerjee   +5 more
doaj   +1 more source

Galnt1 is required for normal heart valve development and cardiac function.

PLoS ONE, 2015
Congenital heart valve defects in humans occur in approximately 2% of live births and are a major source of compromised cardiac function. In this study we demonstrate that normal heart valve development and cardiac function are dependent upon Galnt1, the
E Tian, Sharon R Stevens, Yu Guan, Danielle A Springer, Stasia A Anderson, Matthew F Starost, Vyomesh Patel, Kelly G Ten Hagen, Lawrence A Tabak   +8 more
doaj   +1 more source