Results 71 to 80 of about 2,930,787 (173)

A script to highlight hydrophobicity and charge on protein surfaces [PDF]

, 2015
The composition of protein surfaces determines both affinity and specificity of protein-protein interactions. Matching of hydrophobic contacts and charged groups on both sites of the interface are crucial to ensure specificity.
Tania eMorán Luengo, Stefan G. D. Rüdiger, Dominique Hagemans, Cellular Protein Chemistry, Ianthe A. E. M. van Belzen, Ianthe A.E.M. van Belzen, van Belzen, Ianthe A E M, Sub Cellular Protein Chemistry, Morán Luengo, Tania, Rüdiger, Stefan G D, Tania Morán Luengo, Dominique eHagemans, Hagemans, Dominique   +12 more
core   +2 more sources

Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis

Cell Communication and Signaling
The proinflammatory cytokines and arachidonic acid (AA)-derived eicosanoids play a key role in cartilage degeneration in osteoarthritis (OA). The lysophosphatidylcholine acyltransferase 3 (LPCAT3) preferentially incorporates AA into the membranes.
Vijay Kondreddy, Rajkumar Banerjee, B. L. A. Prabhavathi Devi, Kathirvel Muralidharan, Selvakumar Piramanayagam   +4 more
doaj   +1 more source

Modulation of the Inflammatory Process by Hypercholesterolemia in Osteoarthritis

Frontiers in Medicine, 2020
Objective: Several studies have linked metabolic syndrome to the development of osteoarthritis (OA) through hypercholesterolemia, one of its components.
Amanda Villalvilla, Ane Larrañaga-Vera, Ana Lamuedra, Sandra Pérez-Baos, Alberto G. López-Reyes, Alberto G. López-Reyes, Gabriel Herrero-Beaumont, Raquel Largo   +7 more
doaj   +1 more source

Kartogenin prevents cartilage degradation and alleviates osteoarthritis progression in mice via the miR-146a/NRF2 axis

Cell Death and Disease, 2021
Osteoarthritis (OA) is a common articular degenerative disease characterized by loss of cartilage matrix and subchondral bone sclerosis. Kartogenin (KGN) has been reported to improve chondrogenic differentiation of mesenchymal stem cells.
Mingzhuang Hou, Yijian Zhang, Xinfeng Zhou, Tao Liu, Huilin Yang, Xi Chen, Fan He, Xuesong Zhu   +7 more
doaj   +1 more source

Growth Plate Morphogens as Potential Modulators of Cellular Tissue Remodeling by Annulus Fibrosus Cells

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT Background Adolescent Idiopathic Scoliosis (AIS) is a spinal deformity of unknown etiology that begins in the intervertebral disc and emerges during pubertal growth. In the vertebral growth plate, adjacent to the disc, powerful growth plate morphogens (GPMs) modulate this growth. We evaluated whether GPMs can also alter the capacity of annulus
K. Stradovnik‐Poikilidis, M. Teunissen, F. M. Riemers, M. van Doeselaar, J. Foolen, F. Abinzano, M. A. Tryfonidou, S. J. P. Callens, K. Ito   +8 more
wiley   +1 more source

Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis

Stem Cell Research & Therapy, 2020
Background This study aimed to investigate the effect of bone marrow mesenchymal stem cell (BMSC)-derived exosome injection on cartilage damage and pain relief in both in vitro and in vivo models of osteoarthritis (OA).
Lei He, Tianwei He, Jianghao Xing, Qing Zhou, Lei Fan, Can Liu, Yuyong Chen, Depeng Wu, Zhenming Tian, Bin Liu, Limin Rong   +10 more
doaj   +1 more source

My Love Story With HIFs in the Disc: A Journey to the Humboldt Research Award

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT The intervertebral disc is a prime example of tissue adaptation to metabolic and mechanical extremes. As the largest avascular organ in the human body, the disc and the central nucleus pulposus (NP) endure constant compressive loading while sustaining a hypoxic, relatively acidic, and hyperosmotic microenvironment that would be inhospitable to
Makarand V. Risbud
wiley   +1 more source

Expression of ADAMTS2 and ADAMTS5 in the salivary gland of rats after radioiodine therapy

, 2018
ObjectiveThe aim of this study was to investigate the presence of ADAMTS2 and ADAMTS5 in the salivary gland (SG) of rats after high-dose radioiodine therapy.MethodsA total of 36 male Wistar albino rats were used for this study.
Gokhan Koca, Koray Demirel, Ekinci, Ozgur, Sadic, Murat, Demircan, Kadir, Kadir Demircan, Meliha Korkmaz, Koca, Gokhan, Sevil O. Halacli, Emre Karakok, OSKAY HALAÇLI, SEVİL, Korkmaz, Meliha, Demirel, Koray, Halacli, Sevil O., Ozgur Ekinci, Murat Sadic, Karakok, Emre   +16 more
core   +1 more source

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 468-484, September 2026.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, Volume 13, Issue 46, 17 August 2026.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source