Results 31 to 40 of about 5,085,110 (360)

Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs

eLife, 2020
The organizational integrity of the adaptive immune system is determined by functionally discrete subsets of CD4+ T cells, but it has remained unclear to what extent lineage choice is influenced by clonotypically expressed T-cell receptors (TCRs).
Sofya A Kasatskaya, Kristin Ladell, Evgeniy S Egorov, Kelly L Miners, Alexey N Davydov, Maria Metsger, Dmitry B Staroverov, Elena K Matveyshina, Irina A Shagina, Ilgar Z Mamedov, Mark Izraelson, Pavel V Shelyakin, Olga V Britanova, David A Price, Dmitriy M Chudakov   +14 more
doaj   +1 more source

Surface NKG2C Identifies Differentiated αβT-Cell Clones Expanded in Peripheral Blood

Frontiers in Immunology, 2021
T cells that express CD56 in peripheral blood of healthy humans represent a heterogeneous and poorly studied subset. In this work, we analyzed this subset for NKG2C expression. In both CD56+ and CD56− subsets most of the NKG2C+ T cells had a phenotype of
Elena I. Kovalenko, Ivan V. Zvyagin, Maria A. Streltsova, Artem I. Mikelov, Artem I. Mikelov, Sofya A. Erokhina, William G. Telford, Alexander M. Sapozhnikov, Yury B. Lebedev   +8 more
doaj   +1 more source

Insights on adaptive and innate immunity in canine leishmaniosis [PDF]

, 2016
Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities.
Abi Abdallah, Alexander, Catchpole, DAMER P. BLAKE, de Souza Carmo, Green, Kensil, LAIA SOLANO-GALLEGO, Lopez, Margarito, Ordeix, Pinelli, Pitta, Quinnell, Sadick, Sanchez, SHAZIA HOSEIN, Silva, Vouldoukis, Wakelin   +19 more
core   +4 more sources

Role of actin cytoskeleton at multiple levels of T cell activation

AIMS Molecular Science, 2016
Actin cytoskeleton is an essential cellular structure that is involved in many physiological aspects, including T cell antigenic responses. In has been proposed that actin modulates biophysical parameters of the antigen recognition, forms a barrier ...
Martina Huranova, Ondrej Stepanek
doaj   +1 more source

Integrative Genomics Reveals the Genetics and Evolution of the Honey Bee’s Social Immune System [PDF]

, 2019
Social organisms combat pathogens through individual innate immune responses or through social immunity—behaviors among individuals that limit pathogen transmission within groups.
Currie, Rob, Desai, Suresh, Foster, Leonard, Guarna, Maria Marta, Harpur, Brock, Higo, Heather, Hoover, Shelley, Huxter, Elizabeth, Ibrahim, Abdullah, Melathopoulos, Andony, Moon, Kyung-Mee, Pernal, Stephen, Zayed, Amro   +12 more
core   +1 more source

CD98hc facilitates B cell proliferation and adaptive humoral immunity. [PDF]

, 2009
The proliferation of antigen-specific lymphocytes and resulting clonal expansion are essential for adaptive immunity. We report here that B cell-specific deletion of the heavy chain of CD98 (CD98hc) resulted in lower antibody responses due to total ...
A Mondino, AP Warren, AW Freidman, C Brakebusch, CA Fenczik, CA Fenczik, CC Feral, CC Feral, Cecille D Browne, CG Lo, CG Proud, Chloé C Féral, CL Abram, D Torrents, DC Otero, DE White, DM Rose, E Arana, F Esteban, FD Batista, FM Burnet, GW Prager, H Tsumura, J Bertran, J Fernandez-Herrera, J Hasbold, JG Cyster, JH Kehrl, JL Walker, Joseph Cantor, K Hara, K Roovers, KB Lin, KL Wolniak, L Kass, L Van Parijs, LA Diaz Jr., MA Schwartz, Mark H Ginsberg, MD Cooper, ML Motti, NC Henderson, R Zent, Raphael Ruppert, RC Rickert, Reinhard Fässler, RK Assoian, RO Hynes, Robert C Rickert, RT Abraham, SG Tangye, SJ Fleire, T Lammermann, T Uinuk-Ool, TN Sims, TT Lu, Y Shimizu   +56 more
core   +2 more sources

Influence of tumors on protective anti-tumor immunity and the effects of irradiation [PDF]

, 2013
Innate and adaptive immunity play important roles in the development and progression of cancer and it is becoming apparent that tumours can influence the induction of potentially protective responses in a number of ways.
Alan Graham Pockley, Gabriele eMulthoff, Gabriele eMulthoff, Gemma Ann Foulds, Gemma Ann Foulds, Jürgen eRadons, Mira eKreuzer   +6 more
core   +2 more sources

CXCL12 Mediates Aberrant Costimulation of B Lymphocytes in Warts, Hypogammaglobulinemia, Infections, Myelokathexis Immunodeficiency

Frontiers in Immunology, 2017
The Warts, Hypogammaglobulinemia, Infections, Myelokathexis (WHIM) syndrome is an immunodeficiency caused by mutations in chemokine receptor CXCR4. WHIM patient adaptive immunity defects remain largely unexplained.
Giuliana Roselli, Elisa Martini, Vassilios Lougaris, Raffaele Badolato, Antonella Viola, Antonella Viola, Marinos Kallikourdis, Marinos Kallikourdis   +7 more
doaj   +1 more source

Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells

Cell Reports, 2020
Summary: Overtly self-reactive T cells are removed during thymic selection. However, it has been recently established that T cell self-reactivity promotes protective immune responses.
Veronika Horkova, Ales Drobek, Daniel Mueller, Celine Gubser, Veronika Niederlova, Lena Wyss, Carolyn G. King, Dietmar Zehn, Ondrej Stepanek   +8 more
doaj   +1 more source

Immunity in society: diverse solutions to common problems [PDF]

, 2012
Understanding how organisms fight infection has been a central focus of scientific research and medicine for the past couple of centuries, and a perennial object of trial and error by humans trying to mitigate the burden of disease.
Babayan, S.A., Schneider, D.S.
core   +3 more sources